1. Signaling Pathways
  2. Apoptosis
  3. Ferroptosis


Ferroptosis is a non-apoptotic form of regulated cell death. It is distinct from other regulated cell death phenotypes, such as apoptosis and necroptosis. Ferroptosis is characterized by extensive lipid peroxidation, which can be suppressed by iron chelators or lipophilic antioxidants. Mechanistically, Ferroptosis inducers are divided into two classes: (1) inhibitors of cystine import via system xc (e.g., Erastin), which subsequently causes depletion of glutathione (GSH), and (2) covalent inhibitors (e.g., (1S, 3R)-RSL3) of glutathione peroxidase 4 (GPX4). Since GPX4 reduces lipid hydroperoxides using GSH as a co-substrate, both compound classes ultimately result in loss of GPX4 activity, followed by elevated levels of lipid reactive oxygen species (ROS) and consequent cell death.

Ferroptosis is an iron- and ROS-dependent form of regulated cell death (RCD). Misregulated Ferroptosis has been implicated in multiple physiological and pathological processes, including cancer cell death, neurotoxicity, neurodegenerative diseases, acute renal failure, drug-induced hepatotoxicity, hepatic and heart ischemia/reperfusion injury, and T-cell immunity.

Ferroptosis Related Products (8):

Cat. No. Product Name Effect Purity
  • HY-15763
    Erastin Activator 99.42%
    Erastin is a ferroptosis inducer. Erastin binds and inhibits voltage-dependent anion channels (VDAC2/VDAC3).
  • HY-100579
    Ferrostatin-1 Inhibitor 99.72%
    Ferrostatin-1 is a potent inhibitor of ferroptosis with an EC50 of 60 nM.
  • HY-12726
    Liproxstatin-1 Inhibitor 98.15%
    Liproxstatin-1 is a potent ferroptosis inhibitor, with IC50 of approximately 38 nM.
  • HY-114481
    Imidazole ketone erastin Activator 99.67%
    Imidazole ketone erastin (IKE) is a potent, selective, and metabolically stable inhibitor of the cystine-glutamate antiporter, system Xc- and an activator of ferroptosis.
  • HY-103087
    FIN56 Activator 98.03%
    FIN56 is a specific inducer of ferroptosis.
  • HY-112909A
    UAMC-3203 hydrochloride Inhibitor 98.82%
    UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM.
  • HY-112063
    CIL56 Activator 99.02%
    CIL56 is a potent and selective ferroptosis inducer. Ferroptosis is an iron-dependent form of regulated cell death (RCD).
  • HY-112909
    UAMC-3203 Inhibitor
    UAMC-3203 is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM.
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