1. Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
    Apoptosis
  2. Reactive Oxygen Species
    Ferroptosis
    Apoptosis
  3. Trolox

Trolox 

Cat. No.: HY-101445 Purity: 99.87%
Handling Instructions

Trolox is an analogue of vitamin E with a powerful antioxidant effect. Trolox is also a powerful inhibitor of membrane damage.

For research use only. We do not sell to patients.

Trolox Chemical Structure

Trolox Chemical Structure

CAS No. : 53188-07-1

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
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1 g USD 60 In-stock
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5 g USD 180 In-stock
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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of Trolox:

Top Publications Citing Use of Products

    Trolox purchased from MCE. Usage Cited in: Oxid Med Cell Longev. 2020 Jan 27;2020:5829521.

    The effects of Trolox on the expression of Nrf2 and its downstream targets. MDBK cells in 60 mm dishes pretreated with Trolox (1 mM) or DMSO control for 1 h are exposed to tBHP in the presence of Trolox or DMSO control for 2 h; the cell lysates are prepared for Western blots to detect the expression of Nrf2 and HO-1.
    • Biological Activity

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    Description

    Trolox is an analogue of vitamin E with a powerful antioxidant effect. Trolox is also a powerful inhibitor of membrane damage[1][2].

    In Vitro

    Trolox has shown to protect mammalian cells from oxidative damage. Trolox is effective in preventing myocyte necrosis in cell culture studies and in a canine model of two hours of left anterior descending coronary artery (LAD) occlusion followed by four hours of reperfusion[1].
    Trolox could prevent oxidative stress-induced apoptosis in thymocytes. Pre- or posttreatment of cells with Trolox reduced H2O2-induced DNA fragmentation to control levels and below. [2].
    Trolox is a hydrophilic analogue of alpha-tocopherol and reported to scavenge peroxyl radicals better than vitamin E in sodium dodecyl sulfate micelles and in liposomes. Trolox prolongs substantially the survival of human ventricular myocytes and hepatocyte against oxyradicals generated with xanthine oxidase plus hypoxanthine, and prevented lysis of red cells exposed to an azo-initiator[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    250.29

    Formula

    C14H18O4

    CAS No.
    SMILES

    O=C(C1(C)CCC2=C(C)C(O)=C(C)C(C)=C2O1)O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (399.54 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.9954 mL 19.9768 mL 39.9537 mL
    5 mM 0.7991 mL 3.9954 mL 7.9907 mL
    10 mM 0.3995 mL 1.9977 mL 3.9954 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.08 mg/mL (8.31 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.08 mg/mL (8.31 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.08 mg/mL (8.31 mM); Clear solution

    *All of the co-solvents are available by MCE.
    References
    Cell Assay
    [1]

    Thymocytes are treated with Trolox (10 mM) before, during, or after 10 min exposure to 10 μM H2O2. Trolox incubations that are conducted before or after H2O2 exposures are performed in TCM. Trolox treatments that are administered concurrently with H2O2 are performed in PBS with ferrous sulfate[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References

    Purity: 99.87%

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    Product Name:
    Trolox
    Cat. No.:
    HY-101445
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