2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  3. Reactive Oxygen Species Ferroptosis Apoptosis
  4. Trolox

Trolox 

Cat. No.: HY-101445 Purity: 99.87%
COA Handling Instructions

Trolox is an analogue of vitamin E with a powerful antioxidant effect. Trolox is also a powerful inhibitor of membrane damage.

For research use only. We do not sell to patients.

Trolox Chemical Structure

Trolox Chemical Structure

CAS No. : 53188-07-1

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10 mM * 1 mL in DMSO
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1 g USD 60 In-stock
5 g USD 180 In-stock
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Customer Review

Based on 10 publication(s) in Google Scholar

Other Forms of Trolox:

Trolox Related Antibodies

Top Publications Citing Use of Products

    Trolox purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2020 Jan 27;2020:5829521.  [Abstract]

    The effects of Trolox on the expression of Nrf2 and its downstream targets. MDBK cells in 60 mm dishes pretreated with Trolox (1 mM) or DMSO control for 1 h are exposed to tBHP in the presence of Trolox or DMSO control for 2 h; the cell lysates are prepared for Western blots to detect the expression of Nrf2 and HO-1.

    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Trolox is an analogue of vitamin E with a powerful antioxidant effect. Trolox is also a powerful inhibitor of membrane damage[1][2].

    In Vitro

    Trolox has shown to protect mammalian cells from oxidative damage. Trolox is effective in preventing myocyte necrosis in cell culture studies and in a canine model of two hours of left anterior descending coronary artery (LAD) occlusion followed by four hours of reperfusion[1].
    ? Trolox could prevent oxidative stress-induced apoptosis in thymocytes. Pre- or post-treatment of cells with Trolox reduced H2O2-induced DNA fragmentation to control levels and below. [2].
    ? ? Trolox is a hydrophilic analog of alpha-tocopherol and reported to scavenge peroxyl radicals better than vitamin E in sodium dodecyl sulfate micelles and in liposomes. Trolox prolongs substantially the survival of human ventricular myocytes and hepatocyte against oxyradicals generated with xanthine oxidase plus hypoxanthine, and prevented lysis of red cells exposed to an azo-initiator[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Trolox Related Antibodies
    Molecular Weight

    250.29

    Appearance

    Solid

    Formula

    C14H18O4
    CAS No.
    SMILES

    O=C(C1(C)CCC2=C(C)C(O)=C(C)C(C)=C2O1)O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 1 year
    -20°C 6 months
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (399.54 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.9954 mL 19.9768 mL 39.9537 mL
    5 mM 0.7991 mL 3.9954 mL 7.9907 mL
    10 mM 0.3995 mL 1.9977 mL 3.9954 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (8.31 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (8.31 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.08 mg/mL (8.31 mM); Clear solution

    *All of the co-solvents are available by MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.87%

    COA (247 KB) HNMR (261 KB) LCMS (91 KB)

    Handling Instructions (2659 KB)
    References
    Cell Assay
    [1]

    Thymocytes are treated with Trolox (10 mM) before, during, or after 10 min exposure to 10 μM H2O2. Trolox incubations that are conducted before or after H2O2 exposures are performed in TCM. Trolox treatments that are administered concurrently with H2O2 are performed in PBS with ferrous sulfate[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    References
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    Trolox Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    Trolox53188-07-1Reactive Oxygen SpeciesFerroptosisApoptosisInhibitorinhibitorinhibit

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