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  2. Calcium Channel Reactive Oxygen Species Apoptosis Endogenous Metabolite
  3. L-Ascorbic acid sodium salt

L-Ascorbic acid sodium salt  (Synonyms: Sodium ascorbate; Sodium L-ascorbate; Vitamin C sodium salt; Vitamine C sodium salt)

Cat. No.: HY-B0166A Purity: 99.17%
COA Handling Instructions

L-Ascorbic acid sodium salt (Sodium ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid sodium salt selectively inhibits Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid sodium salt is also a collagen deposition enhancer and an elastogenesis inhibitor.

For research use only. We do not sell to patients.

L-Ascorbic acid sodium salt Chemical Structure

L-Ascorbic acid sodium salt Chemical Structure

CAS No. : 134-03-2

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Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
USD 55 In-stock
Solution
10 mM * 1 mL in Water USD 55 In-stock
Solid
500 mg USD 50 In-stock
1 g USD 60 In-stock
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Customer Review

Based on 30 publication(s) in Google Scholar

Other Forms of L-Ascorbic acid sodium salt:

Top Publications Citing Use of Products

30 Publications Citing Use of MCE L-Ascorbic acid sodium salt

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  • Purity & Documentation

  • References

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Description

L-Ascorbic acid sodium salt (Sodium ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid sodium salt selectively inhibits Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid sodium salt is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3].

IC50 & Target

T-type calcium channel

 

Microbial Metabolite

 

Human Endogenous Metabolite

 

In Vitro

The conditioned medium for B16F10 cells significantly inhibits cell apoptosis induced by L-Ascorbic acid sodium salt (Sodium L-ascorbate) (10 mM), and the effective ingredients in the medium show a relative molecular mass below 5,000[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tg rats treated with L-Ascorbic acid sodium salt (Sodium L-ascorbate) show a higher incidence of carcinoma (29.6%), compared to those without L-Ascorbic acid sodium salt (15.4%). Independent of the L-Ascorbic acid sodium salt treatment, transgenic rats exhibit various kinds of malignant tumors in various organs[5].
After 12 weeks of PEITC-treatment, both simple hyperplasia and papillary or nodular (PN) hyperplasia have developed in all animals, but the majority of these lesions have disappeared at week 48, irrespective of the L-Ascorbic acid sodium salt-treatment. The same lesions after 24 weeks of PEITC-treatment have progressed to dysplasia and carcinoma, in a small number of cases by week 48, but enhancement by the L-Ascorbic acid sodium salt-treatment is evident only with simple hyperplasias and PN hyperplasias in rats[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

198.11

Formula

C6H7NaO6

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O[C@@H](CO)[C@]1([H])C(O[Na])=C(O)C(O1)=O

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (504.77 mM; Need ultrasonic)

DMSO : 1 mg/mL (5.05 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0477 mL 25.2385 mL 50.4770 mL
5 mM 1.0095 mL 5.0477 mL 10.0954 mL
10 mM 0.5048 mL 2.5239 mL 5.0477 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (252.39 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.17%

References
Animal Administration
[3]

A total of 40 7-week-old male Tg rats are divided into 2 groups. Twenty-seven (group 1) and 13 (group 2) rats are given a powdered MF diet with or without 5% sodium L-ascorbate, respectively. Similarly, a total of 42 7-week-old male Non-tg rats are divided into 2 groups, and 30 (group 3) and 12 (group 4) animals are given a diet with or without 5% sodium L-ascorbate, respectively.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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L-Ascorbic acid sodium salt
Cat. No.:
HY-B0166A
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