Tris(3-hydroxypropyltriazolylmethyl)amine (Synonyms: THPTA)

Cat. No.: HY-W021042 Purity: ≥97.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Tris(3-hydroxypropyltriazolylmethyl)amine (THPTA, compound 3) is an accelerating ligand in the copper-catalyzed azide-alkyne cycloaddition reaction (CuAAC). Tris(3-hydroxypropyltriazolylmethyl)amine protects the histidine moiety of biomolecules in a manner proportional to ligand concentration.

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Tris(3-hydroxypropyltriazolylmethyl)amine Chemical Structure

CAS No. : 760952-88-3

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100 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
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Description

Molecular Weight

434.50

Formula

C₁₈H₃₀N₁₀O₃

CAS No.

760952-88-3

Appearance

Solid

Color

White to light brown

SMILES

OCCCN1N=NC(CN(CC2=CN(CCCO)N=N2)CC3=CN(CCCO)N=N3)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (230.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3015 mL	11.5075 mL	23.0150 mL
5 mM	0.4603 mL	2.3015 mL	4.6030 mL
10 mM	0.2301 mL	1.1507 mL	2.3015 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥97.0%

Select Batch:

Data Sheet (271 KB) SDS (0 KB)

COA (250 KB) HNMR (119 KB)

Handling Instructions (2659 KB)

References

[1]. Hong V, et al. Analysis and optimization of copper-catalyzed azide-alkyne cycloaddition for bioconjugation. Angew Chem Int Ed Engl. 2009;48(52):9879-83. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3015 mL	11.5075 mL	23.0150 mL	57.5374 mL
	5 mM	0.4603 mL	2.3015 mL	4.6030 mL	11.5075 mL
	10 mM	0.2301 mL	1.1507 mL	2.3015 mL	5.7537 mL
	15 mM	0.1534 mL	0.7672 mL	1.5343 mL	3.8358 mL
	20 mM	0.1151 mL	0.5754 mL	1.1507 mL	2.8769 mL
	25 mM	0.0921 mL	0.4603 mL	0.9206 mL	2.3015 mL
	30 mM	0.0767 mL	0.3836 mL	0.7672 mL	1.9179 mL
	40 mM	0.0575 mL	0.2877 mL	0.5754 mL	1.4384 mL
	50 mM	0.0460 mL	0.2301 mL	0.4603 mL	1.1507 mL
	60 mM	0.0384 mL	0.1918 mL	0.3836 mL	0.9590 mL
	80 mM	0.0288 mL	0.1438 mL	0.2877 mL	0.7192 mL
	100 mM	0.0230 mL	0.1151 mL	0.2301 mL	0.5754 mL

Tris(3-hydroxypropyltriazolylmethyl)amine Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tris(3-hydroxypropyltriazolylmethyl)amine760952-88-3THPTABiochemical Assay ReagentsCopper catalysisazide-alkyne cycloaddition reactionclick chemistry reactionInhibitorinhibitorinhibit

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