Ninjurin
Ninjurin
Ninjurin, a chemical that promotes nerve regeneration and healing after peripheral nerve injury, was found in the dorsal root ganglion neurons and Schwann cells following nerve damage. Ninjurin is upregulated in endometriosis, interacts with inflammatory factors, and is crucial to the mechanisms underlying endometriosis-related pain. Endometriosis-related pain is a form of neuroinflammatory pain, and Ninjurin plays a crucial role in the physiological and pathological processes of the nervous system[1].
Verweise:
- [1]. David L, et al. NINJ1 mediates plasma membrane rupture by cutting and releasing membrane disks. Cell. 2024 Apr 25;187(9):2224-2235.e16. [Content Brief]
- [2]. Hu S, et al. Potential link between the nerve injury-induced protein (Ninjurin) and the pathogenesis of endometriosis. Int Immunopharmacol. 2023 Jan;114:109452.
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Ninjurin Verwandte Produkte (1)
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Glycine
0 ImagesGlycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. Glycine is orally active. Glycine inhibits the membrane aggregation of NINJ1 and prevents plasma membrane rupture during cell death. Glycine can be used to study cell protection, cancer, neurological diseases, and angiogenesis.
