2. Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel Protein Tyrosine Kinase/RTK Epigenetics
  3. Endogenous Metabolite iGluR VEGFR Small Interfering RNA (siRNA)
  4. Glycine

Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. Glycine is orally active. Glycine can be used to study cell protection, cancer, neurological diseases, and angiogenesis.

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Glycine Chemical Structure

Glycine Chemical Structure

CAS No. : 56-40-6

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10 mM * 1 mL in Water
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Based on 4 publication(s) in Google Scholar

Other Forms of Glycine:

Glycine Related Antibodies

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Description

Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. Glycine is orally active. Glycine can be used to study cell protection, cancer, neurological diseases, and angiogenesis[1][2][3][4][5][6].

IC50 & Target

NMDA Receptor

 

Human Endogenous Metabolite

 

Microbial Metabolite

 

NINJ1

 

In Vitro

Glycine (0-1 mM, 0-48 h) has anti-tumor and anti-angiogenic effects. It can downregulate the production of VEGF in tumor cells HCT-116, HT-29 and CC-531, inhibit the growth of endothelial cells HUVEC through GlyR, and indirectly inhibit HUVEC migration and capillary formation[3].
Glycine (5 mM, 50 mM, 10 min) can prevent the aggregation of NINJ1 in the plasma membrane and inhibit cell death caused by the breakdown of NINJ1 dependent property membrane, thereby exerting its cytoprotective effect[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glycine Related Antibodies

Cell Migration Assay [3]

Cell Line: HUVEC cells
Concentration: 0, 0.01, 0.1, or 1 mM
Incubation Time: 0-48 h
Result: Reduced VEGF or conditioned medium-stimulated HUVEC migration and angiogenesis but had no direct effect on HUVEC migration.
In Vivo

Glycine (single 40-800 mg/kg, i.p.) dose-dependently prevents scopolamine (HY-N0296)-induced social cognitive impairment in adult rats[2].
Glycine (500 and 1000 mg/kg/day for 14 days, i.p.) can significantly reduce kidney damage in lead-exposed mice by inhibiting ROS production[5].
Glycine (single 1 or 2 g/kg, p.o.) increases extracellular serotonin but not dopamine in the prefrontal cortex of rats

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: renal injury in mice exposed to Pb, adult male BALB/c mice (25–30 g)[5]
Dosage: 500 and 1000 mg/kg/day for 14 days
Administration: i.p.
Result: Significantly reduces elevated serum BUN and creatinine levels due to lead exposure.
Significantly reduced ROS elevation in renal tissue due to lead exposure.
Mitigated renal histopathological alterations in mice exposed to lead, included tubular dilation, protein cast, vacuolization, and inflammation.
Clinical Trial
Molecular Weight

75.07

Formula

C2H5NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NCC(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (333.02 mM; Need ultrasonic)

Methanol : < 1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 13.3209 mL 66.6045 mL 133.2090 mL
5 mM 2.6642 mL 13.3209 mL 26.6418 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.26%

COA (303 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 13.3209 mL 66.6045 mL 133.2090 mL 333.0225 mL
5 mM 2.6642 mL 13.3209 mL 26.6418 mL 66.6045 mL
10 mM 1.3321 mL 6.6605 mL 13.3209 mL 33.3023 mL
15 mM 0.8881 mL 4.4403 mL 8.8806 mL 22.2015 mL
20 mM 0.6660 mL 3.3302 mL 6.6605 mL 16.6511 mL
25 mM 0.5328 mL 2.6642 mL 5.3284 mL 13.3209 mL
30 mM 0.4440 mL 2.2202 mL 4.4403 mL 11.1008 mL
40 mM 0.3330 mL 1.6651 mL 3.3302 mL 8.3256 mL
50 mM 0.2664 mL 1.3321 mL 2.6642 mL 6.6605 mL
60 mM 0.2220 mL 1.1101 mL 2.2202 mL 5.5504 mL
80 mM 0.1665 mL 0.8326 mL 1.6651 mL 4.1628 mL
100 mM 0.1332 mL 0.6660 mL 1.3321 mL 3.3302 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Glycine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glycine56-40-6Endogenous MetaboliteiGluRVEGFRSmall Interfering RNA (siRNA)Ionotropic glutamate receptorsVascular endothelial growth factor receptorcancerangiogenesisHCT-116 cellHT-29 cellCC-531 cellHUVEC cellcell migrationkidney damage in lead-exposed micesocial cognitive impairment in adult ratsInhibitorinhibitorinhibit

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