2. Disease Areas
  3. Infection
  4. Viral Infection
  5. HSV Infection

HSV Infection

Congenital herpes virus infection results from maternal-fetal transmission of the herpes simplex virus, leading to a range of fetal and neonatal complications. While herpes typically causes recurrent cutaneous infections in adults—commonly on the lips or genitalia—systemic involvement of organs such as the liver or central nervous system can occur, particularly in newborns. Maternal herpes infection during pregnancy is associated with adverse outcomes including preterm delivery, intrauterine growth restriction, and neonatal infection. The greatest risk to the fetus arises during delivery when exposure to the virus can lead to severe, potentially life-threatening neonatal herpes, affecting the skin, eyes, mouth, central nervous system, or disseminated organs.

HSV Infection (28):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-125474
    Carrageenan 9000-07-1
    Carrageenan is an antiviral and anticancer agent. Carrageenan inhibits herpes simplex virus (HSV), HIV, and hepatitis A virus (HAV) by directly binding to the viral capsid to block the attachment of viruses such as HPV to HSPG factors on the cell surface. Carrageenan delays and arrests cell cycle progression, exhibits cytotoxicity against HeLa cancer cells, and can be applied to studies related to cervical cancer, genital warts, hepatitis A, and other conditions. Carrageenan also induces acute non-immune inflammation, triggers a three-phase inflammatory response involving the release of multiple proinflammatory mediators, and causes persistent edema, hyperalgesia, and neutrophil recruitment in mice.
    Carrageenan
  • HY-113041
    Prostaglandin A2 13345-50-1 99.9%
    Prostaglandin A2 (PGA2) is a Cyclopentenone prostaglandin. Prostaglandin A2 induces Caspase-dependent Apoptosis, activates p53. Prostaglandin A2 activates ERK2 and JNK1/SAPK. Prostaglandin A2 shows antiviral activity against HSV-1. Prostaglandin A2 has anti-tumor effects. Prostaglandin A2 can be used for the research of colorectal cancer, colorectal carcinoma, breast carcinoma, and herpetic keratitis.
    Prostaglandin A2
  • HY-169798
    1,9-Dimethylmethylene blue 23481-50-7 98.06%
    1,9-Dimethylmethylene blue is a photosensitizer, virus inactivator and hemoglobin oxidant derived from methylene blue. When activated, 1,9-Dimethylmethylene blue generates reactive oxygen species including singlet oxygen, and acts as a metachromatic dye. When activated in monomeric or dimeric form, 1,9-Dimethylmethylene blue induces photoinactivation of R17 phage and vesicular stomatitis virus and oxidizes hemoglobin via non-singlet oxygen reactive oxygen species or singlet oxygen-mediated pathways, respectively. The monomeric form, with higher nucleic acid affinity, achieves virus inactivation under specific conditions without forming methemoglobin. 1,9-Dimethylmethylene blue binds to substances such as glycosaminoglycans to produce color changes. Although it is susceptible to interference from non-glycosaminoglycan components in urine, it is still applicable to spectrophotometric analysis for glycosaminoglycan quantification. With these unique photochemical and binding properties, 1,9-Dimethylmethylene blue is widely used in studies of viral infections and related biochemical analyses.
    1,9-Dimethylmethylene blue
  • HY-110354
    UCM05 1094451-90-7 99.22%
    UCM05 (G28UCM) is a fatty acid synthase (FASN) and filamentous temperature-sensitive protein Z (Ftsz) inhibitor. UCM05 inhibits fatty acid synthesis, viral replication, and Gram-positive bacterial growth. UCM05 binds to FtsZ GTP-binding sites, inhibits GTPase activity, and disrupts Z-ring localization. UCM05 can be used for the research of HSV-1/2 infection, HIV-1 infection, and Gram-positive bacterial infections[1][2][3].
    UCM05
  • HY-173679
    RBN012811 2569517-30-0 98.79%
    RBN012811 is a highly selective PROTAC-based PARP14 degrader. RBN012811 forms a ternary complex with cereblon by binding to the NAD+ site of PARP14, and mediates the specific degradation of PARP14 via the ubiquitin-proteasome pathway (IC50=10 nM). RBN012811 effectively depletes endogenous PARP14 in various cell lines and primary human macrophages, thereby downregulating IL-10 production and IFN-β mRNA levels, increasing phosphorylated STAT1 levels to enhance inflammatory signaling, and inhibiting interferon-induced ADPr condensate formation. RBN012811 also modulates viral replication, exhibiting increased HSV1 replication while reducing VSV replication. RBN012811 has important application value in research related to cancer and viral infections.
    RBN012811
  • HY-180844
    ABI-5366 3030615-13-2
    ABI-5366 is a helicase-primase inhibitor. ABI-5366 can be used for research of herpes simplex virus (HSV) infection.
    ABI-5366
  • HY-165459
    KJM429 401907-57-1
    KJM429 (MK-056) is a high-affinity ligand for the rat vanilloid receptor rTRPV1 (Ki=30-63 nM) with a unique dual regulatory function. KJM429 acts as a competitive antagonist to inhibit TRPV1 receptor activation induced by Capsaicin (HY-10448), resiniferatoxin, thermal stimulation and weak acid (pH 6.0), and switches to a TRPV1 agonist under strong acid conditions (pH<5.5). KJM429 effectively blocks calcium influx induced by Capsaicin and partial thermal stimulation, and triggers calcium uptake under low pH conditions, with minimal effects on non-TRPV1-mediated calcium signaling. KJM429 can be used for research on the mechanisms of pain-related diseases such as postherpetic neuralgia, diabetic neuropathy, cluster headache, osteoarthritis and pruritus.
    KJM429
  • HY-104083
    North-methanocarbathymidine 156126-12-4
    North-methanocarbathymidine (N-MCT) is a potent antiviral agent. North-methanocarbathymidine inhibits DNA synthesis. North-methanocarbathymidine demonstrates potent antiviral activity against HSV-1, HSV-2 and KSHV. North-methanocarbathymidine exhibits anticancer activity against colon adenocarcinoma expressing HSV-tk.
    North-methanocarbathymidine
  • HY-N12717
    Casuarinin 79786-01-9 98.24%
    Casuarinin is an orally active antiproliferative, anti-inflammatory, antifungal, virucidal and gastroprotective agent. Casuarinin upregulates the expression of p21/WAF1, Fas/APO‑1, mFasL, sFasL and HSP‑70, arrests cell cycle, induces apoptosis and inhibits cancer cell proliferation. Casuarinin inhibits TNF‑α-induced phosphorylation of MAPK and activation of NF‑κB, downregulates the expression of iNOS, NF‑κB, COX‑2 and ICAM‑1, and reduces the production of proinflammatory mediators. Casuarinin attenuates ethanol-induced activation of caspase‑3 and elevation of TNF‑α, inhibits the growth of Candida albicans, and inhibits HSV‑2. Casuarinin can be used in research related to mammary adenocarcinoma, inflammatory skin diseases, gastric ulcers, candidiasis and herpes simplex virus infections.
    Casuarinin
  • HY-113431
    Arabinosylhypoxanthine 7013-16-3 99.0%
    Arabinosylhypoxanthine is a purine nucleoside analog. Arabinosylhypoxanthine selectively inhibits viral DNA synthesis. Arabinosylhypoxanthine exhibits anti-HSV activity. Arabinosylhypoxanthine can be used in studies related to herpes simplex virus infection.
    Arabinosylhypoxanthine
  • HY-160222
    HSV-60mer sodium 98.11%
    HSV-60mer sodium is a 60 bp double-stranded DNA oligonucleotide derived from the HSV-1 genome, and also an IFNβ inducer. HSV-60mer sodium colocalizes with endogenous cytoplasmic IFI16 in immune cells. HSV-60mer sodium activates the transcription factors IRF3 and NF-κB, induces the production of proinflammatory cytokines, and inhibits HSV-1 replication in immune cells. HSV-60mer sodium can be used in studies related to herpes simplex virus type 1 infection.
    HSV-60mer sodium
  • HY-50735
    Fiacitabine 69123-90-6 99.27%
    Fiacitabine (NSC 382097; FIAC; FOAC) is a potent and highly selective anti-herpesvirus agent. Fiacitabine acts as an inhibitor of HSV DNA polymerase, with a Ki of 0.26 μM for HSV-1 and 0.42 μM for HSV-2, respectively. Fiacitabine can be efficiently phosphorylated by thymidine kinase encoded by the virus itself to generate FIACTP, an active triphosphate metabolite. Fiacitabine is applicable to research related to herpesvirus infections.
    Fiacitabine
  • HY-163529
    HN0037 2233566-79-3 99.46%
    HN0037 is a selective, orally active Helicase-primase inhibitor. HN0037 is mainly metabolized by CYP3A4. HN0037 inhibits HSV replication by targeting the viral helicase-primase complex, which consists of three proteins encoded by UL5 (helicase), UL52 (primase), and UL8 (scaffold protein that promotes primer synthesis).
    HN0037
  • HY-110354R
    UCM05 (Standard) 1094451-90-7
    UCM05 (Standard) is the analytical standard of Lysipressin. This product is intended for research and analytical applications. UCM05 (G28UCM) is a fatty acid synthase (FASN) and filamentous temperature-sensitive protein Z (Ftsz) inhibitor. UCM05 inhibits fatty acid synthesis, viral replication, and Gram-positive bacterial growth. UCM05 binds to FtsZ GTP-binding sites, inhibits GTPase activity, and disrupts Z-ring localization. UCM05 can be used for the research of HSV-1/2 infection, HIV-1 infection, and Gram-positive bacterial infections[1][2][3].
    UCM05 (Standard)
  • HY-186203
    8-Bromo-harmane 144434-73-1
    8-Bromo-harmane is a β-carboline derivative with anti-HSV-1 activity. 8-Bromo-harmane is non-cytotoxic. 8-Bromo-harmane can be used for the research of herpes simplex virus 1 (HSV-1) infection.
    8-Bromo-harmane
  • HY-P11022
    TL-119 55599-68-3
    TL-119 (A-3302-B) is a polypeptide. TL-119 can be isolated from the bacteria Micromonospora sp. MAG 9-7 and Saccharomonospora sp. CNQ-490. TL-119 inhibits TRPV-1. TL-119 exhibits antiviral activity against HSV-2. TL-119 possesses anticancer activity against gastric cancer and colorectal cancer.
    TL-119
  • HY-P11714
    EBNA3 246-254 457881-09-3
    EBNA3 246-254 (RYSIFFDYM) is an EBV peptide. EBNA3 246-254 is submitted by HLA-A24. EBNA3 246-254 is amplified in vitro, followed by HLA multimer staining to measure EBV-specific CTLs. EBNA3 246-254 can be used for the research of lung cancer.
    EBNA3 246-254
  • HY-P11713
    EBNA3B 399-408 179815-06-6
    EBNA3B 399-408 is an immunodominant HLA-A11-restricted cytotoxic T-lymphocyte epitope in EBNA3B. EBNA3B 399-408 can be used in the research of EBV infection, empyema-associated lymphoma, and nasal natural killer cell lymphoma.
    EBNA3B 399-408
  • HY-N18293
    Makisterone A 2-acetate 189197-33-9
    Makisterone A 2-acetate is a steroid compound that can be isolated from the 75% ethanol extract of Cyanotis arachnoidea. Experimental tests show that Makisterone A 2-acetate has no anti-HSV-1 activity.
    Makisterone A 2-acetate
  • HY-N9865
    cis-Martynoside 155899-92-6
    cis-Martynoside is a phenylpropanoid glycoside. Cis-Martynoside, in a mixture with trans-Martynoside, effectively inhibits the early activation of the lytic cycle of Epstein-Barr virus (EBV) and reduces the expression of Rta protein. cis-Martynoside can be used in research on EBV infection.
    cis-Martynoside