69123-90-6
Chemical Structure
Fiacitabine
Synonym(s): NSC 382097; FIAC; FOAC
- CAS No.: 69123-90-6
- Formula:C9H11FIN3O4
- Molecular Weight:371.10
IUPAC Name: 4-amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-iodopyrimidin-2(1H)-one
InChIKey: GIMSJJHKKXRFGV-BYPJNBLXSA-N
SMILES: OC[C@@H]1[C@@H](O)[C@H](F)[C@H](N(C=C2I)C(N=C2N)=O)O1
Biological Activity: Fiacitabine (NSC 382097; FIAC; FOAC) is a potent and highly selective anti-herpesvirus agent. Fiacitabine acts as an inhibitor of HSV DNA polymerase, with a Ki of 0.26 μM for HSV-1 and 0.42 μM for HSV-2, respectively. Fiacitabine can be efficiently phosphorylated by thymidine kinase encoded by the virus itself to generate FIACTP, an active triphosphate metabolite. Fiacitabine is applicable to research related to herpesvirus infections[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Fiacitabine | 99.27% | Fiacitabine (NSC 382097; FIAC; FOAC) is a potent and highly selective anti-herpesvirus agent. Fiacitabine acts as an inhibitor of HSV DNA polymerase, with a Ki of 0.26 μM for HSV-1 and 0.42 μM for HSV-2, respectively. Fiacitabine can be efficiently phosphorylated by thymidine kinase encoded by the virus itself to generate FIACTP, an active triphosphate metabolite. Fiacitabine is applicable to research related to herpesvirus infections. | ||||||||||||||||||||
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Similarity Score 0.86
HY-1290572',5-Difluoro-2'-deoxycytidine -
Similarity Score 0.85
HY-1527055-Bromo-2’-deoxy-2’-fluoro-beta-D-arabinocytidine -
Similarity Score 0.84
HY-1527632’-Deoxy-2’-fluoro-5-methylcytidine -
Similarity Score 0.84
HY-1528112′-Deoxy-2′-fluoro-5-methyl-arabinocytidine -
Similarity Score 0.83
HY-W0086155-Iodo-cytidine -
Similarity Score 0.81
HY-W128788A2’-Deoxy-2’-fluoro-b-D-arabinocytidine hydrochloride -
Similarity Score 0.81
HY-W0120092'-Deoxy-2'-fluorocytidine -
Similarity Score 0.81
HY-W1287882’-Deoxy-2’-fluoro-b-D-arabinocytidine -
Similarity Score 0.80
HY-1528225-Iodo-2’-O-methylcytidine -
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References
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[1]. Allaudeen HS, et al. Selective inhibition of DNA replication in herpes simplex virus infected cells by 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine. J Biol Chem. 1982 Oct 25;257(20):11879-82. PMID: 6288702.
[Content Brief] - [2]. Lopez C, et al. 2'-fluoro-5-iodo-aracytosine, a potent and selective anti-herpesvirus agent. Antimicrob Agents Chemother. 1980;17(5):803-806. [Content Brief]
