1. Anti-infection
  2. HSV
  3. Fiacitabine

Fiacitabine (Synonyms: NSC 382097; FIAC; FOAC)

Cat. No.: HY-50735 Purity: 98.93%
Handling Instructions

Fiacitabine(NSC 382097; FIAC; FOAC) is a selective inhibitior of DNA replication of herpes simplex virus(HSV) with IC50 values of 2.5 nM and 12.6 nM for HSV1 and HSV2, respectively.

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Fiacitabine Chemical Structure

Fiacitabine Chemical Structure

CAS No. : 69123-90-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 462 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Description

Fiacitabine(NSC 382097; FIAC; FOAC) is a selective inhibitior of DNA replication of herpes simplex virus(HSV) with IC50 values of 2.5 nM and 12.6 nM for HSV1 and HSV2, respectively. IC50 value: 2.5/12.6 nM (HSV1/2) [2] Target: HSV FIAC suppressed by 90% the replication of various strains of herpes simplex virus types 1 and 2 at concentrations of 0.0025 to 0.0126 microM. Cytotoxicity was minimal, as determined by trypan blue dye exclusion with norman Vero, WI-38, and NC-37 cell proliferation; the 50% inhibitory dose was 4 to 10 microM in a 4-day assay. FIAC was active at much lower concentrations than arabinosylcytosine, iododeoxyuridine, and arabinosyladenine. It was slightly more active against herpes simplex virus type 1 than acycloquanosine and slightly more toxic to normal cells. FIAC was about 8,000 times more active against the replication of wild-type herpes simplex virus type 1 than against a mutant strain lacking the expression of virus-specified thymidine kinase [2].

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 37 mg/mL (99.70 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6947 mL 13.4735 mL 26.9469 mL
5 mM 0.5389 mL 2.6947 mL 5.3894 mL
10 mM 0.2695 mL 1.3473 mL 2.6947 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

371.10

Formula

C₉H₁₁FIN₃O₄

CAS No.

69123-90-6

SMILES
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Fiacitabine
Cat. No.:
HY-50735
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Fiacitabine

Cat. No.: HY-50735