1. Anti-infection
  2. HSV
  3. Omaciclovir

Omaciclovir (Synonyms: H2G)

Cat. No.: HY-116174 Purity: 99.20% ee.: 95.07%
Handling Instructions

Omaciclovir (H2G) is a potent and selective inhibitor of herpesvirus replication. Omaciclovir is a nucleoside analog with antiviral activity.

For research use only. We do not sell to patients.

Omaciclovir Chemical Structure

Omaciclovir Chemical Structure

CAS No. : 124265-89-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 550 In-stock
Estimated Time of Arrival: December 31
5 mg USD 500 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
50 mg USD 3000 In-stock
Estimated Time of Arrival: December 31
100 mg USD 4600 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Omaciclovir (H2G) is a potent and selective inhibitor of herpesvirus replication. Omaciclovir is a nucleoside analog with antiviral activity[1].

In Vitro

Omaciclovir is a nucleoside analog with in vitro inhibitory activity against varicella-zoster virus (VZV), herpes simplex virus types 1 and 2 (HSV-1 and -2), Epstein-Barr virus, and human herpesvirus 6. Omaciclovir is also efficacious in simian varicella virus-infected monkeys[1].
Omaciclovir shows antiviral activities against different human herpesviruses with EC50s of 0.72 ± 0.1, 0.62 ± 0.2, 0.015 ± 0.004, 0.048 ± 0.023, 0.047 ± 0.004, 0.035 ± 0.022, and 0.016 ± 0.003 μM for MRC-5 VZV-32, MRC-5 Molly, MeWo VZV-32, MeWo Molly, MeWo Emily, MeWo VZ11, and MeWo VZ30, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

253.26

Formula

C₁₀H₁₅N₅O₃

CAS No.
SMILES

O=C1NC(N)=NC2=C1N=CN2C[[email protected]](CO)CCO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 230 mg/mL (908.16 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9485 mL 19.7426 mL 39.4851 mL
5 mM 0.7897 mL 3.9485 mL 7.8970 mL
10 mM 0.3949 mL 1.9743 mL 3.9485 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5.75 mg/mL (22.70 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 5.75 mg/mL (22.70 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5.75 mg/mL (22.70 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

OmaciclovirH2GHSVHerpes simplex virusherpesvirusantiviralvaricella-zostervirusVZVEpstein-BarrInhibitorinhibitorinhibit

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Product Name:
Omaciclovir
Cat. No.:
HY-116174
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