Search Result

Results for "

HSV

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HSV (97) Acyltransferase (1) Adenosine Receptor (1) Akt (2) Androgen Receptor (1) Antibiotic (19) Apoptosis (13) ATP Synthase (1) Autophagy (9) Bacterial (20) Biochemical Assay Reagents (1) Cathepsin (2) CDK (2) Cholinesterase (ChE) (1) CMV (9) COX (1) CRISPR/Cas9 (1) Cytochrome P450 (1) DNA/RNA Synthesis (8) Drug Metabolite (2) EBV (1) Endogenous Metabolite (11) ERK (1) FAK (1) Ferroptosis (2) Fungal (3) GSK-3 (2) HBV (2) HCV (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Demethylase (2) HIV (8) HPV (1) HSP (1) Influenza Virus (2) Interleukin Related (1) Isotope-Labeled Compounds (9) Mitophagy (1) MMP (1) Monoamine Oxidase (1) NF-κB (1) NOD-like Receptor (NLR) (1) Nucleoside Antimetabolite/Analog (13) Orthopoxvirus (6) Parasite (6) Phosphatase (1) Proton Pump (2) SARS-CoV (4) SGLT (1) STAT (3) STING (2) Thymidylate Synthase (2) Toll-like Receptor (TLR) (2) Tyrosinase (1) VEGFR (1) VSV (1) YB-1 (1)
By Research Areas:	Cancer (40) Cardiovascular Disease (1) Infection (104) Inflammation/Immunology (15) Metabolic Disease (5) Neurological Disease (6)

By Targets:

HSV (97)

Acyltransferase (1)

Adenosine Receptor (1)

Akt (2)

Androgen Receptor (1)

Antibiotic (19)

Apoptosis (13)

ATP Synthase (1)

Autophagy (9)

Bacterial (20)

Biochemical Assay Reagents (1)

Cathepsin (2)

CDK (2)

Cholinesterase (ChE) (1)

CMV (9)

COX (1)

CRISPR/Cas9 (1)

Cytochrome P450 (1)

DNA/RNA Synthesis (8)

Drug Metabolite (2)

EBV (1)

Endogenous Metabolite (11)

ERK (1)

FAK (1)

Ferroptosis (2)

Fungal (3)

GSK-3 (2)

HBV (2)

HCV (1)

HIF/HIF Prolyl-Hydroxylase (1)

Histone Demethylase (2)

HIV (8)

HPV (1)

HSP (1)

Influenza Virus (2)

Interleukin Related (1)

Isotope-Labeled Compounds (9)

Mitophagy (1)

MMP (1)

Monoamine Oxidase (1)

NF-κB (1)

NOD-like Receptor (NLR) (1)

Nucleoside Antimetabolite/Analog (13)

Orthopoxvirus (6)

Parasite (6)

Phosphatase (1)

Proton Pump (2)

SARS-CoV (4)

SGLT (1)

STAT (3)

STING (2)

Thymidylate Synthase (2)

Toll-like Receptor (TLR) (2)

Tyrosinase (1)

VEGFR (1)

VSV (1)

YB-1 (1)

By Research Areas:

Cancer (40)

Cardiovascular Disease (1)

Infection (104)

Inflammation/Immunology (15)

Metabolic Disease (5)

Neurological Disease (6)

121

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies

Targets Recommended: HSV

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-149023

HSV-1/HSV-2-IN-2	HSV	Infection
HSV-1/HSV-2-IN-2 is a *HSV-1, HSV-2* and VV inhibitor with EC₅₀ values of 6.8, 8.9 and 8.9 µM, respectively. HSV-1/HSV-2-IN-2 shows antiviral activity .

HY-149022

HSV-1/HSV-2-IN-1	HSV Orthopoxvirus	Infection
HSV-1/HSV-2-IN-1 (compound 7d) is a *HSV-1* and *HSV-2* inhibitor, with EC₅₀s of 7.6, 7.6, 4, and 12 μM for HSV-1 (KOS), HSV-2 (G), HSV-1 TK ^- KOS ACV ^r and vaccinia virus in human embryonic lung fibroblast cell cultures .

HY-126218

HSV-TK substrate	HSV	Cancer
HSV-TK substrate is a substrate for HSV-TK, and induces multi-log cytotoxicity in HSV-TK-expressing and bystander cells. HSV-TK substrate shows antitumor activity .

HY-160222

HSV-60mer sodium	HSV STING	Infection Inflammation/Immunology
HSV-60mer sodium is a 60 bp double-stranded oligonucleotide containing viral DNA motifs that derive from the herpes simplex virus 1 (HSV-1) genome . Transfected HSV-60 has been shown to potently induce IFN-β in a Toll-like receptor (TLR)-, DNA-dependent activator of IRFs (DAI)-, and RNA polymerase III (Pol III)-independent, but STING-, TBK1- and IFN regulatory factor 3 (IRF3)-dependent manner.

HY-P4773

HSV-1 Protease substrate	HSV	Infection
HSV-1 Protease substrate is a peptide substrate for HSV-1 (Herpes Simplex Virus Type 1) protease, and the specificity constant (k_cat/K_m) at pH 7.5 for cleavage is 5.2 M ^-1 s ^-1 .

HY-P1862

HSV-gB2 (498-505)	HSV	Infection
HSV-gB2 (498-505) is an immunodominant epitope from herpes simplex virus (HSV) glycoprotein B residues 498-505, acts as H-2Kb-restricted and HSV-1/2-cross-reactive cytotoxic T-lymphocyte (CTL) recognition epitope .

HY-131606

Cidofovir diphosphate	Others	Infection
Cidofovir diphosphate is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate is a selective inhibitor of viral DNA polymerases with K_i values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively .

HY-131606B

Cidofovir diphosphate tri(triethylamine)	Drug Metabolite	Infection
Cidofovir diphosphate tri triethylamine is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate tri triethylamine is a selective inhibitor of viral DNA polymerases with K_i values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively .

HY-N0097S5

Guanosine-d13 DL-Guanosine-d₁₃; Vernine-d₁₃	Isotope-Labeled Compounds	Infection
Guanosine-d13 (DL-Guanosine-d13) is a deuterium of Guanosine (HY-N0097). Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity .

HY-N0097S6

Guanosine-13C10,15N5 DL-Guanosine-¹³C₁₀,¹⁵N₅; Vernine-¹³C₁₀,¹⁵N₅	HSV Isotope-Labeled Compounds	Infection
Guanosine- ¹³C₁₀, ¹⁵N₅ is the ¹³C and ¹⁵N labeled Guanosine (HY-N0097). Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity .

HY-135117

Glyceryl monocaprate Monocaprin	Bacterial HSV	Infection
Glyceryl monocaprate (Monocaprin) is a 1-monoglyceride of capric acid against gram-positive bacterial infections . Glyceryl monocaprate (Monocaprin has inhibitory effect on Herpes Simplex Virus (HSV) and offers an effective treatment for herpes labialiss .

HY-N0097S4

Guanosine-13C10 DL-Guanosine-¹³C₁₀; Vernine-¹³C₁₀	Isotope-Labeled Compounds Endogenous Metabolite HSV	Infection
Guanosine- ¹³C₁₀ is the ¹³C labeled Guanosine (HY-N0097). Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity .

HY-148169

2'-Deoxy-L-guanosine	Nucleoside Antimetabolite/Analog	Infection
2'-Deoxy-L-guanosine selectively inhibits D-Thymidine phosphorylation catalyzed by HSV 1 thymidine kinase. 2'-Deoxy-L-guanosine is the L-configuration of 2'-Deoxyguanosine (HY-17563) .

HY-N7346

Lucidadiol	HSV Cholinesterase (ChE)	Infection
Lucidadiol is a natural compound isolated from Ganoderma lucidum. Lucidadiol exhibits acetylcholinesterase-inhibitory activity, with IC₅₀ values of 31 μM. Lucidadiol shows antiviral activity against influenza virus type A and HSV type 1 .

HY-W291131

Isatin-β-thiosemicarbazone IBT	HSV Orthopoxvirus	Infection
Isatin-β-thiosemicarbazone is a potent anti-poxvirus agent (including monkeypox virus, orthopoxvirus, vaccinia virus, etc). Isatin-β-thiosemicarbazone also is a potent herpes simplex virus (HSV) inhibitor. Isatin-β-thiosemicarbazone exhibits

HY-19333

OG-L002 1 Publications Verification	Histone Demethylase Monoamine Oxidase HSV	Infection
OG-L002 is a potent and highly selective LSD1 inhibitor with an IC₅₀ of 0.02 μM. OG-L002 is a potent monoamine oxidases (MAO) inhibitor with IC₅₀s of 1.38 μM and 0.72 μM for MAO-A and MAO-B, respectively. OG-L002 potently inhibits the expression of HSV IE genes .

HY-116758

16,16-Dimethyl prostaglandin A1 di-Me-PGA1	DNA/RNA Synthesis HIV HSV	Infection Cancer
16,16-Dimethyl prostaglandin A1 (di-Me-PGA1) is a prostaglandin analog that can inhibit DNA synthesis in Lewis lung carcinoma and B 16 amelanotic melanoma cells. 16,16-Dimethyl prostaglandin A1 also inhibits viral replication in both *HSV* and HIV-1 infection systems .

HY-100272

B220

HSV CMV Infection Cancer

B220 is an antiviral agent which can inhibit the growth of HSV-1, HSV-2 and human cytomegalovirus (CMV).
HY-U00124

Tromantadine

HSV Infection

Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and HSV-2 replication .

B220	HSV CMV	Infection Cancer
B220 is an antiviral agent which can inhibit the growth of *HSV-1, HSV-2* and human cytomegalovirus (CMV).

Tromantadine	HSV	Infection
Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and HSV-2 replication .

HY-U00124B

Tromantadine hydrochloride 1 Publications Verification	HSV	Infection
Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and *HSV-2* replication .

HY-15303

Pritelivir 3 Publications Verification AIC316; BAY 57-1293	HSV	Infection
Pritelivir (AIC316), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir is active against herpes simplex virus types 1 and 2 (HSV-1 and *HSV-2) with the IC₅₀ of 0.02 μM against HSV*1-2 .

HY-15303B

Pritelivir mesylate hydrate 3 Publications Verification AIC316 mesylate hydrate; BAY 57-1293 mesylate hydrate	HSV	Infection
Pritelivir mesylate hydrate (BAY 57-1293 mesylate hydrate), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir mesylate hydrate is active against herpes simplex virus types 1 and 2 (HSV-1 and *HSV-2) with the IC₅₀ of 0.02 μM against HSV*1-2 .

HY-15303A

Pritelivir mesylate 3 Publications Verification AIC316 mesylate; BAY 57-1293 mesylate	HSV	Infection
Pritelivir mesylate (BAY 57-1293 mesylate), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir mesylate is active against herpes simplex virus types 1 and 2 (HSV-1 and *HSV-2) with the IC₅₀ of 0.02 μM against HSV*1-2 .

HY-A0181A

Adenosine 5'-monophosphate monohydrate 5+ Cited Publications 5'-AMP monohydrate	Adenosine Receptor HSV Endogenous Metabolite	Infection Neurological Disease
Adenosine 5'-monophosphate monohydrate is an adenosine A₁ receptor agonist. Adenosine 5'-monophosphate monohydrate has significant antiviral activity against *HSV-1* and *HSV-2*.

HY-N7677

Isookanin	HSV	Infection Inflammation/Immunology Cancer
Isookanin can be used for the research of various illnesses including cancers, skin rashes, snake and insects bites, diabetes mellitus, diarrhoea. Isookanin acts as an anti-viral agent against HSV and varicella-zoster virus (VZV). Antioxidant activity .

HY-108137

Z-LVG-CHN2 2 Publications Verification	Cathepsin HSV SARS-CoV	Infection Inflammation/Immunology
Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on *HSV* whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC₅₀=190 nM) via inhibition of SARS-COV-2 3CL pro protease .

HY-N10177

Peniterphenyl A	HSV	Infection
Peniterphenyl A is a natural product obtained from a deep-sea-derived Penicillium sp. Peniterphenyl A inhibits *HSV-1/2* virus entry into cells and may block HSV-1/2 infection through direct interaction with virus envelope glycoprotein D to interfere with virus adsorption and membrane fusion. Peniterphenyl A is a promising lead compound against HSV-1/2 .

HY-107801

Inosine pranobex 1 Publications Verification Imunovir; Delimmun; Groprinosin	Interleukin Related HSV HIV HPV	Infection Inflammation/Immunology
Inosine pranobex is an orally active immunomodulator. Inosine pranobex has broad-spectrum antiviral activity. Inosine pranobex inhibits human immunodeficiency virus (HIV), herpes simplex virus (HSV), vaccinia virus (VACV), human tumor virus (HPV), Cytomegalovirus, influenza virus (INFV), parainfluenza virus (PIV), and Epstein-Barr virus .

HY-50735

Fiacitabine NSC 382097; FIAC; FOAC	HSV	Infection
Fiacitabine(NSC 382097; FIAC; FOAC) is a selective inhibitior of DNA replication of herpes simplex virus(HSV) with IC50 values of 2.5 nM and 12.6 nM for HSV1 and HSV2, respectively.

HY-108137A

Z-L(D-Val)G-CHN2	Cathepsin HSV SARS-CoV	Infection
Z-L(D-Val)G-CHN2 is the isoform of Z-LVG-CHN2 (HY-108137). Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on *HSV* whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC₅₀=190 nM) via inhibition of SARS-COV-2 3CL pro protease .

HY-17424

Penciclovir 1 Publications Verification BRL 39123; VSA 671	HSV	Infection
Penciclovir (VSA 671) is a potent and selective anti-herpesvirus agent with EC₅₀ values of 0.5, 0.8 µg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir shows anti-herpesvirus activity with no-toxic. Penciclovir preventes mortality in mouse .

HY-107739

Penciclovir sodium VSA 671 sodium; BRL 39123A; BRL 39123D	HSV	Infection
Penciclovir (VSA 671) sodium is a potent and selective anti-herpesvirus agent with EC₅₀ values of 0.5, 0.8 µg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir sodium shows anti-herpesvirus activity with no-toxic. Penciclovir sodium preventes mortality in mouse .

HY-U00224

BRL44385	EBV HSV	Infection
BRL44385 is a potent and selective inhibitor of the replication of herpes simplex virus types 1 and 2 (HSV-1 and *HSV2*), varicella zoster virus (VZV) and Epstein-Barr virus (EBV).

HY-B0277

Vidarabine 5 Publications Verification Ara-A; Adenine Arabinoside; 9-β-D-Arabinofuranosyladenine	HSV Nucleoside Antimetabolite/Analog Orthopoxvirus Antibiotic	Infection
Vidarabine (Ara-A) an antiviral agent which is active against herpes simplex and varicella zoster viruses . Vidarabine has IC₅₀s of 9.3 μg/ml for HSV-1 and 11.3 μg/ml for HSV-2 . Vidarabine also has anti-orthopoxvirus activity .

HY-W004486

Gallic aldehyde

HSV Infection

Gallic aldehyde is a HSV-1 inhibitor isolated from Geum japonicum, with potent antiviral activity .

Gallic aldehyde	HSV	Infection
Gallic aldehyde is a *HSV-1* inhibitor isolated from Geum japonicum, with potent antiviral activity .

HY-N1067

Xanthohumol 5+ Cited Publications	COX Acyltransferase Apoptosis HSV CMV Influenza Virus	Infection Cancer
Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, *HSV-1, HSV-2* and cytomegalovirus (CMV).

HY-17422

Acyclovir 5+ Cited Publications Aciclovir; Acycloguanosine	HSV Apoptosis Antibiotic Bacterial	Infection Cancer
Acyclovir (Aciclovir) is a potent, orally active antiviral agent. Acyclovir has antiherpetic activity with IC₅₀ values of 0.85 μM and 0.86 μM for *HSV-1* and *HSV-2, respectively. Acyclovir induces cell cycle perturbation and apoptosis*. Acyclovir prevents bacterial infections during induction therapy for acute leukaemia .

HY-17422A

Acyclovir sodium Aciclovir sodium; Acycloguanosine sodium	HSV Apoptosis Antibiotic Bacterial	Infection Cancer
Acyclovir (Aciclovir) sodium is a potent, orally active antiviral agent. Acyclovir sodium has antiherpetic activity with IC₅₀ values of 0.85 μM and 0.86 μM for *HSV-1* and *HSV-2, respectively. Acyclovir sodium induces cell cycle perturbation and apoptosis*. Acyclovir sodium prevents bacterial infections during induction therapy for acute leukaemia .

HY-18944

FIT-039
FIT-039 is a selective, ATP-competitive and orally active CDK9 inhibitor with an IC₅₀ of 5.8 μM for CKD9/cyclin T1. FIT-039 does not inhibit other CDKs and other kinases. FIT-039 inhibits replication of *HSV-1* (IC₅₀ of 0.69 μM), *HSV-2, human adenovirus, and human CMV. FIT-039 is a promising antiviral agent for inhibiting drug-resistant HSVs* and other DNA viruses.

HY-N1430

Oxyresveratrol trans-Oxyresveratrol	Tyrosinase HSV Autophagy	Others
Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC₅₀ of 28.9 µM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC₅₀ value of 1.2 µM for mushroom tyrosinase. Oxyresveratrol is effective against *HSV-1, HSV-2* and varicella-zoster virus, and has neuroprotective effects .

HY-P1958

Histone H4 (2-21)

HSV Infection

Histone H4 (2-21) is the core histones associated with chromatinization of herpes simplex virus 1 (HSV-1) genomes .

Histone H4 (2-21)	HSV	Infection
Histone H4 (2-21) is the core histones associated with chromatinization of herpes simplex virus 1 (HSV-1) genomes .

HY-15486

Salubrinal 15+ Cited Publications	Phosphatase HSV Autophagy Apoptosis	Infection Inflammation/Immunology Cancer
Salubrinal is a cell-permeable and selective inhibitor of eIF2α dephosphorylation . Salubrinal acts as a dual-specificity phosphatase 2 (Dusp2) inhibitor and suppresses inflammation in anti-collagen antibody-induced arthritis . Salubrinal has antiviral activity against *HSV-1* and inhibits dephosphorylation of eIF2α mediated by the *HSV-1* protein ICP34.5 .

HY-122920

Soyasaponin II	HSV CMV Influenza Virus HIV NOD-like Receptor (NLR) YB-1	Infection Inflammation/Immunology
Soyasaponin II is a saponin with antiviral activity. Soyasaponin II inhibits the replication of HSV-1, HCMV, influenza virus, and HIV-1. Soyasaponin II shows potent inhibition on HSV-1 replication. Soyasaponin II serves as a inhibitor for YB-1 phosphorylation and NLRP3 inflammasome priming and could protect mice against LPS/GalN induced acute liver failure .

HY-P3626

Astodrimer SPL7013 free base	Bacterial HCV SARS-CoV	Infection
Astodrimer (SPL7013 free base) is a large (3-4 nm, ~ 16.5 kDa), negatively charged, highly-branched dendrimer, is a potent virucidal agent. Astodrimer shows antiviral and virucidal activity against a broad spectrum of viruses, including SARS-CoV-2, HIV-1, HSV-1, HSV-2, HPV. Astodrimer also has antibacterial properties .

HY-P5567

GLR-19

HIV HSV Infection

GLR-19 is an anti-HIV peptide. GLR-19 also has antiviral activity against HSV-2 .

GLR-19	HIV HSV	Infection
GLR-19 is an anti-HIV peptide. GLR-19 also has antiviral activity against *HSV-2* .

HY-P5693

HBA(111–142)	Bacterial CMV HSV	Infection
HBA(111-142), an antimicrobial peptide, is a C-terminal 32-mer fragment of alpha-hemoglobin. HBA(111-142) has antibacterial activity against the ESKAPE panel of pathogens. HBA(111-142) forms amyloid fibrils, and has antiviral activities. HBA(111-142) inhibits measles and herpes viruses (HSV-1, HSV-2, HCMV) .

HY-12725

ML324 5+ Cited Publications	Histone Demethylase HSV CMV	Cancer
ML324 is a potent JMJD2 demethylase inhibitor with antiviral activity. ML324 also exhibits inhibition for the histone demethylase KDM4B, with an IC₅₀ of 4.9 μM. ML324 has potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression .

HY-W002008

5-Nitrobarbituric acid

HSV Infection Inflammation/Immunology

5-Nitrobarbituric acid is a herpes simplex virus type-1 (HSV-1) inhibitor (IC₅₀=1.7 μM) .

HY-18684

SIBA 5'-Isobutylthioadenosine; 5'-Deoxy-5'-isobutylthioadenosine	Nucleoside Antimetabolite/Analog HSV Parasite	Infection Metabolic Disease Cancer
SIBA (5'-Isobutylthioadenosine) is a transmethylation inhibitor (SAH (HY-19528) analogue), with potent anti-proliferative activity. SIBA reversibly inhibits the production of HSV-1 by blocking methylation, specifically by blocking the 5' end-capping of viral mRNA. SIBA also inhibits the growth of tumour cells in vitro and metastatic spread in vivo. SIBA can be used in cancer, HSV-1 infection and anti-malaria studies .

HY-N8082

Stearyl gallate	HSV	Infection
Stearyl gallate is an alkyl gallate with a long alkyl chain (carbon number of 18). Stearyl gallate has an antioxidant activity, and a weak antiviral activity against *HSV-1* .

Cat. No.	Product Name	Target	Research Area

HY-P1862

HSV-gB2 (498-505)	HSV	Infection
HSV-gB2 (498-505) is an immunodominant epitope from herpes simplex virus (HSV) glycoprotein B residues 498-505, acts as H-2Kb-restricted and HSV-1/2-cross-reactive cytotoxic T-lymphocyte (CTL) recognition epitope .

HY-P1958

Histone H4 (2-21)

HSV Infection

Histone H4 (2-21) is the core histones associated with chromatinization of herpes simplex virus 1 (HSV-1) genomes .

HY-P4773

HSV-1 Protease substrate	HSV	Infection
HSV-1 Protease substrate is a peptide substrate for HSV-1 (Herpes Simplex Virus Type 1) protease, and the specificity constant (k_cat/K_m) at pH 7.5 for cleavage is 5.2 M ^-1 s ^-1 .

HY-P5997

XQ2B	Peptides	Inflammation/Immunology
XQ2B is a cGAS inhibitor targeting protein-DNA interactions and phase separation. XQ2B inhibits herpes simplex virus 1 (HSV-1)-induced antiviral immune responses and enhances HSV-1 infection in vitro and in vivo .

HY-P3626

Astodrimer SPL7013 free base	Bacterial HCV SARS-CoV	Infection
Astodrimer (SPL7013 free base) is a large (3-4 nm, ~ 16.5 kDa), negatively charged, highly-branched dendrimer, is a potent virucidal agent. Astodrimer shows antiviral and virucidal activity against a broad spectrum of viruses, including SARS-CoV-2, HIV-1, HSV-1, HSV-2, HPV. Astodrimer also has antibacterial properties .

HY-P5567

GLR-19

HIV HSV Infection

GLR-19 is an anti-HIV peptide. GLR-19 also has antiviral activity against HSV-2 .

HY-P5693

HBA(111–142)	Bacterial CMV HSV	Infection
HBA(111-142), an antimicrobial peptide, is a C-terminal 32-mer fragment of alpha-hemoglobin. HBA(111-142) has antibacterial activity against the ESKAPE panel of pathogens. HBA(111-142) forms amyloid fibrils, and has antiviral activities. HBA(111-142) inhibits measles and herpes viruses (HSV-1, HSV-2, HCMV) .

HY-P2036

FSL-1

Toll-like Receptor (TLR) Antibiotic Infection

FSL-1, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection .

HY-P4318

HHV-2 Envelope Glycoprotein G (552-574)	HSV	Infection
HHV-2 Envelope Glycoprotein G (552-574) is an immunodominant region of glycoprotein G (gG-2) reactive with all herpes simplex (HSV-2) sera .

HY-P4743

FITC-εAhx-HHV-2 Envelope Glycoprotein G (561-578)	HSV	Infection
FITC-εAhx-HHV-2 Envelope Glycoprotein G (561-578) is a FITC labeled HHV-2 Envelope Glycoprotein G (561-578). HHV-2 Envelope Glycoprotein G (561-578) is an immunodominant region of glycoprotein G (gG-2) reactive with all herpes simplex (HSV-2) sera .

HY-P2036A

FSL-1 TFA 3 Publications Verification	Toll-like Receptor (TLR) MMP HSV Antibiotic	Infection
FSL-1 TFA, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection . FSL-1 TFA induces MMP-9 production through TLR2 and NF-κB/AP-1 signaling pathways in monocytic THP-1 cells .

HY-14743

Golotimod SCV 07; Gamma-D-glutamyl-L-tryptophan	Bacterial STAT	Infection Inflammation/Immunology Cancer
Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-A0181A

Adenosine 5'-monophosphate monohydrate 5+ Cited Publications 5'-AMP monohydrate	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Adenosine Receptor HSV Endogenous Metabolite
Adenosine 5'-monophosphate monohydrate is an adenosine A₁ receptor agonist. Adenosine 5'-monophosphate monohydrate has significant antiviral activity against *HSV-1* and *HSV-2*.

HY-N7677

Isookanin	Infection Flavonoids Classification of Application Fields Deguelia rufescens (Benth.) R.A.Camargo & A.M.G.Azevedo Flavonones Source classification Phenols Polyphenols Plants Compositae Disease Research Fields Inflammation/Immunology	HSV
Isookanin can be used for the research of various illnesses including cancers, skin rashes, snake and insects bites, diabetes mellitus, diarrhoea. Isookanin acts as an anti-viral agent against HSV and varicella-zoster virus (VZV). Antioxidant activity .

HY-B0277

Vidarabine 5 Publications Verification Ara-A; Adenine Arabinoside; 9-β-D-Arabinofuranosyladenine	Infection Structural Classification Microorganisms Antibiotics Source classification Antiviral Antibacterial Disease Research Disease Research Fields	HSV Nucleoside Antimetabolite/Analog Orthopoxvirus Antibiotic
Vidarabine (Ara-A) an antiviral agent which is active against herpes simplex and varicella zoster viruses . Vidarabine has IC₅₀s of 9.3 μg/ml for HSV-1 and 11.3 μg/ml for HSV-2 . Vidarabine also has anti-orthopoxvirus activity .

HY-N7346

Lucidadiol	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	HSV Cholinesterase (ChE)
Lucidadiol is a natural compound isolated from Ganoderma lucidum. Lucidadiol exhibits acetylcholinesterase-inhibitory activity, with IC₅₀ values of 31 μM. Lucidadiol shows antiviral activity against influenza virus type A and HSV type 1 .

HY-N10177

Peniterphenyl A	Infection Structural Classification Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Disease Research Fields	HSV
Peniterphenyl A is a natural product obtained from a deep-sea-derived Penicillium sp. Peniterphenyl A inhibits *HSV-1/2* virus entry into cells and may block HSV-1/2 infection through direct interaction with virus envelope glycoprotein D to interfere with virus adsorption and membrane fusion. Peniterphenyl A is a promising lead compound against HSV-1/2 .

HY-N1067

Xanthohumol 5+ Cited Publications	Infection Structural Classification Chalcones Flavonoids Classification of Application Fields Humulus lupulus L. Source classification Phenols Polyphenols Plants Moraceae Disease Research Fields	COX Acyltransferase Apoptosis HSV CMV Influenza Virus
Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, *HSV-1, HSV-2* and cytomegalovirus (CMV).

HY-N1430

Oxyresveratrol trans-Oxyresveratrol	Structural Classification other families Stilbenes Classification of Application Fields Anti-aging Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields	Tyrosinase HSV Autophagy
Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC₅₀ of 28.9 µM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC₅₀ value of 1.2 µM for mushroom tyrosinase. Oxyresveratrol is effective against *HSV-1, HSV-2* and varicella-zoster virus, and has neuroprotective effects .

HY-122920

Soyasaponin II	Triterpenes Structural Classification Classification of Application Fields Leguminosae Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Glycine soja Sieb. Et Zucc.	HSV CMV Influenza Virus HIV NOD-like Receptor (NLR) YB-1
Soyasaponin II is a saponin with antiviral activity. Soyasaponin II inhibits the replication of HSV-1, HCMV, influenza virus, and HIV-1. Soyasaponin II shows potent inhibition on HSV-1 replication. Soyasaponin II serves as a inhibitor for YB-1 phosphorylation and NLRP3 inflammasome priming and could protect mice against LPS/GalN induced acute liver failure .

HY-N1451

Betulonic acid 1 Publications Verification Betunolic acid; Liquidambaric acid; (+)-Betulonic acid	Infection Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields	Parasite HSV
Betulonic acid (Betunolic acid), a naturally occurring triterpene, is found in many plants. Betulonic acid has anti-tumor, anti-inflammatory, antiparasitic and anti-viral (HSV-1) activities .

HY-N3395

Leachianone G	Flavonoids Flavonones Source classification Morus alba L. Plants Moraceae	HSV
Leachianone G is an antiviral flavonoid from the root bark of Morus alba L. Leachianone G shows potent antiviral activity against herpes simplex type 1 virus (HSV-1) with an IC₅₀* value of 1.6 μg/mL .*

HY-17425A

Valacyclovir hydrochloride 1 Publications Verification Valaciclovir hydrochloride	Infection Classification of Application Fields Disease Research Fields	HSV Antibiotic Bacterial
Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits *HSV-1* W (₅₀=2.9 μg/ml). Valacyclovir hydrochloride is a proagent of Aciclovir (HY-17422) .

HY-N11097

FK-3000	Structural Classification Alkaloids Piperidine Alkaloids Source classification Plants Stephania delavayi Diels Menispermaceae	Apoptosis HSV HIV
FK-3000 is a potent anti-tumor agent that inhibits the growth of carcinoma cells through apoptosis and induction cell cycle arrest. FK-3000 also exhibit antiviral effects against *HSV-1* and HIV-1 .

HY-N2584A

Isoxanthohumol 1 Publications Verification	Infection Flavonoids Classification of Application Fields Anti-aging Humulus lupulus L. Flavonones Source classification Plants Moraceae Disease Research Fields Cancer	HSV
Isoxanthohumol is a prenylflavonoid from hops and beer. Isoxanthohumol exhibits an antiproliferative activity against several human cancer cell lines. Isoxanthohumol inhibits the development of lung metastatic foci in tumor-challenged animals. Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV) .

HY-16592

Brefeldin A Maximum Cited Publications 62 Publications Verification BFA; Cyanein; Decumbin	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antiviral Disease Research Anticancer Disease Research Fields	Autophagy CRISPR/Cas9 Mitophagy HSV Antibiotic Bacterial
Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus . Brefeldin A is also an autophagy and mitophagy inhibitor . Brefeldin A is a CRISPR/Cas9 activator . Brefeldin A inhibits *HSV-1* and has anti-cancer activity .

HY-107789

Sodium lauryl sulfoacetate	Structural Classification Saururaceae Classification of Application Fields Houttuynia cordata Thunb. Ketones, Aldehydes, Acids Source classification Plants Inflammation/Immunology Disease Research Fields	Biochemical Assay Reagents HSV
Sodium lauryl sulfoacetate is a solid anionic surfactant of plant origin. Sodium lauryl sulfoacetate is an immunoadjuvant with antiimmunosuppressive effects. Sodium lauryl sulfoacetate has antiviral activity .

HY-N8156

Soyasapogenol C	Infection Triterpenes Trifolium repens Linn. Classification of Application Fields Leguminosae Terpenoids Source classification Plants Disease Research Fields	HSV
Soyasapogenol C is an oleanane-type triterpenoid. Soyasapogenol C exhibits anti-HSV-1 activity, with an IC₅₀ of 18.9 μM .

HY-117010

Kushenol K	Flavanonols Structural Classification Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Metabolic Disease Plants Sophora flavescens Aiton Disease Research Fields	Cytochrome P450 HSV SGLT
Kushenol K, a flavonoid antioxidant isolated from the roots of Sophora flavescens. Kushenol K is a cytochrome P-450 3A4 (CYP3A4) inhibitor with a K_i value of 1.35 μM . Kushenol K shows weak antiviral activity against *HSV-2* (EC₅₀ of 147 μM) . Kushenol K also inhibits the activity of SGLT1 and SGLT2 .

HY-117025A

Manzamine A hydrochloride 1 Publications Verification Keramamine A hydrochloride	Structural Classification Neurological Disease Classification of Application Fields Source classification Marine natural products Pyridine Alkaloids Indole Alkaloids Infection Alkaloids Piperidine Alkaloids Animals Sponge Disease Research Fields	GSK-3 CDK Parasite Proton Pump HSV Autophagy
Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC₅₀s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against *HSV-1* .

HY-117025

Manzamine A Keramamine A	Infection Alkaloids Structural Classification Neurological Disease Classification of Application Fields Animals Marine natural products Sponge Disease Research Fields Cancer	GSK-3 CDK Parasite Proton Pump HSV Autophagy
Manzamine A, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC₅₀s of 10.2 μM and 1.5 μM, respectively. Manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A has antimalarial and anticancer activities. Manzamine A also shows potent activity against *HSV-1* .

HY-113289

Brassicasterol	Infection Classification of Application Fields Animals Source classification Disease Research Fields Steroids Cancer	Akt Androgen Receptor Bacterial Drug Metabolite HSV
Brassicasterol is a metabolite of Ergosterol and has cardiovascular protective effects. Brassicasterol exerts anticancer effects in prostate cancer through dual targeting of AKT and androgen receptor signaling pathways. Brassicasterol inhibits *HSV-1* (IC₅₀=1.2 μM) and Mycobacterium tuberculosis. Brassicasterol also inhibits sterol δ 24-reductase, slowing the progression of atherosclerosis. Brassicasterol is also a cerebrospinal fluid biomarker for Alzheimer's disease .

HY-B0222

1-Docosanol 1 Publications Verification Behenyl alcohol	Infection Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields	HSV
1-Docosanol (Behenyl alcohol) is a saturated fatty alcohol with reported inhibitory activity against lipid-enveloped viruses, including herpes simplex virus (HSV) .

HY-N0097

Guanosine 5+ Cited Publications DL-Guanosine; Vernine	Structural Classification Natural Products Classification of Application Fields Anti-aging Source classification Endocrine diseases Endogenous metabolite Infection Human Gut Microbiota Metabolites Microorganisms Immune System Disorder Disease markers Disease Research Fields	HSV Endogenous Metabolite
Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity.

HY-N12191

Cangorinine E-1	Structural Classification Alkaloids Terpenoids Other Alkaloids Sesquiterpenes Source classification Celastraceae Plants Tripterygium wilfordii Hook. f.	HSV
Cangorinine E-1 (compound 11) is a dihydroagarofuran derivative of the sesquiterpenoid family. Cangorinine E-1 exhibits weak inhibitory effects on herpes simplex virus type II (HSV) .

HY-N2812

Epipodophyllotoxin acetate 4-O-Epipodophyllotoxinyl acetate	Structural Classification Cupressaceae Source classification Lignans Phenylpropanoids Plants	HSV VSV
Epipodophyllotoxin acetate (4-O-Epipodophyllotoxinyl acetate; compound 4) is a cyclolignan that exhibits antineoplastic and antiviral activities. Epipodophyllotoxin acetate inhibits *HSV* and VSV, with IC₅₀s of 0.2 and 0.1 μg/mL, respectively .

HY-13605

Cytarabine 35+ Cited Publications Cytosine β-D-arabinofuranoside; Cytosine Arabinoside; Ara-C	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Marine natural products Sponge Endogenous metabolite Disease Research Fields	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog HSV Autophagy Apoptosis Endogenous Metabolite Orthopoxvirus
Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC₅₀ of 16 nM. Cytarabine has antiviral effects against *HSV*. Cytarabine shows anti-orthopoxvirus activity.

HY-111243

Ganoderone A	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	HSV
Ganoderone A is a triterpene compound that can be isolated from the fruiting body of Ganoderma pfeifferi and Ganoderma calidophilum. Ganoderone A has antiviral activity against *HSV* with IC₅₀ value of 0.3 µg/mL. Ganoderone A has potential applications in viral infections and tumors .

HY-B0275

Oxytetracycline 5 Publications Verification	Structural Classification Classification of Application Fields Source classification Antibacterial Disease Research Endogenous metabolite Other Antibiotics Plant agriculture research Infection Monophenols Microorganisms Antibiotics Resistance Selection Animal Husbandry Phenols Disease Research Fields	Bacterial HSV Endogenous Metabolite Antibiotic
Oxytetracycline is an antibiotic belonging to the tetracycline class. Oxytetracycline potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline also possesses anti-HSV-1 activity .

HY-B0275C

Oxytetracycline calcium	Infection Quinones Structural Classification Classification of Application Fields Anthraquinones Source classification Endogenous metabolite Disease Research Fields	Bacterial HSV Antibiotic Endogenous Metabolite
Oxytetracycline calcium is an antibiotic belonging to the tetracycline class. Oxytetracycline calcium potently inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline calcium is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline calcium also possesses anti-HSV-1 activity .

HY-N8265

Abyssinone V	Structural Classification Flavonoids Leguminosae Flavonones Source classification Erythrina melanacantha Taub. ex Harms Plants	HSV DNA/RNA Synthesis ATP Synthase
Abyssinone V is a prenylated flavonoid with predicted anti-viral activity. Abyssinone V can be isolated from the stem bark of Erythrina melanacantha. Abyssinone V possesses good pharmacodynamics properties. Abyssinone V is predicted to be antivirals including anti-herpes (HSV) agent, with mechanisms comprising inhibition of polymerase, ATPase and membrane integrity .

HY-N0415

Trigonelline chloride 4 Publications Verification Trigonelline hydrochloride	Infection Alkaloids Structural Classification Classification of Application Fields Labiatae Source classification Pyridine Alkaloids Metabolic Disease Lactuca perennis Plants Disease Research Fields	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal
Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti-HSV-1, antibacterial, and antifungal activity, and induces ferroptosis.

HY-N0414

Trigonelline 4 Publications Verification Trigenolline	Structural Classification Classification of Application Fields Source classification Pyridine Alkaloids Metabolic Disease Plants Endogenous metabolite Alkaloids other families Microorganisms Leguminosae Disease Research Fields Trigonella foenum-graecum Linn.	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal
Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis.

Cat. No.	Product Name	Chemical Structure

HY-17422S1

Acyclovir-d4

Acyclovir-d₄ is the deuterium labeled Acyclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC50 of 0.85 μM), HSV-2 (IC50 of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination[1][2][3]. Acyclovir prevents bacterial infections during induction therapy for acute leukaemia[4].

HY-N0097S5

Guanosine-d13
Guanosine-d13 (DL-Guanosine-d13) is a deuterium of Guanosine (HY-N0097). Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity .

HY-N0097S6

Guanosine-13C10,15N5
Guanosine- ¹³C₁₀, ¹⁵N₅ is the ¹³C and ¹⁵N labeled Guanosine (HY-N0097). Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity .

HY-N0097S4

Guanosine-13C10
Guanosine- ¹³C₁₀ is the ¹³C labeled Guanosine (HY-N0097). Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity .

HY-13666S

Levamisole-d5 hydrochloride
Levamisole-d₅ (hydrochloride) is the deuterium labeled Levamisole hydrochloride. Levamisole ((-)-Tetramisole) hydrochloride is an anthelmintic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives. Levamisole hydrochloride has antiviral effects against HSV[1][2].

HY-13605S

Cytarabine-d2
Cytarabine-d₂ is the deuterium labeled Cytarabine. Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV[1][2].

HY-17425AS

Valacyclovir-d8 hydrochloride
Valacyclovir-d₈ (hydrochloride) is the deuterium labeled Valacyclovir hydrochloride. Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits HSV-1 W (50=2.9 μg/ml). Valacyclovir hydrochloride is a proagent of Aciclovir (HY-17422) [1][2][3][4][5].

HY-17425AS1

Valacyclovir-d4 hydrochloride
Valacyclovir-d₄ (hydrochloride) is the deuterium labeled Valacyclovir hydrochloride. Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits HSV-1 W (50=2.9 μg/ml). Valacyclovir hydrochloride is a proagent of Aciclovir (HY-17422)[1][2][3][4][5].

HY-N0415S

Trigonelline-d3 chloride
Trigonelline-d₃ (chloride) is the deuterium labeled Trigonelline chloride. Trigonelline chloride, an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee. Trigonelline chloride has anti-HSV-1 , antibacterial, and antifungal activities.

HY-17424S

Penciclovir-d4
Penciclovir-d₄ is the deuterium labeled Penciclovir. Penciclovir is reported to be potent against HSV types 1 and 2 with IC50 of 0.04-1.8 μg/mL and 0.06-4.4 μg/mL, respectively[1][2].

HY-N0097S3

Guanosine-15N5
Guanosine- ¹⁵N₅ is the ¹⁵N labeled Guanosine[1]. Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity[2].

HY-N0097S1

Guanosine-8-d-1
Guanosine-8-d-1 is the deuterium labeled Guanosine. Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activ[1][2].

HY-A0061S

Trifluridine-13C,15N2
Trifluridine- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Trifluridine[1]. Trifluridine (Trifluorothymidine;5-Trifluorothymidine;TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral agent for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity[2].

HY-13637S

Ganciclovir-d5

Ganciclovir-d₅ is the deuterium labeled Ganciclovir. Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1)[1][2][3].

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