1. Anti-infection
  2. HSV
  3. Pritelivir

Pritelivir (Synonyms: BAY 57-1293; AIC316)

Cat. No.: HY-15303 Purity: 98.38%
Handling Instructions

Pritelivir (BAY 57-1293; AIC316) represents a new class of potent inhibitors of herpes simplex virus (HSV) that target the virus helicase primase complex.

For research use only. We do not sell to patients.

Pritelivir Chemical Structure

Pritelivir Chemical Structure

CAS No. : 348086-71-5

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 70 In-stock
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50 mg USD 150 In-stock
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100 mg USD 250 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Pritelivir (BAY 57-1293; AIC316) represents a new class of potent inhibitors of herpes simplex virus (HSV) that target the virus helicase primase complex.

IC50 & Target

IC50: 20 nM (HSV-1) [1]

In Vitro

BAY 57-1293 is nearly two orders of magnitude more potent than acyclovirin vitro and the superiority was even more prominent when the viral load was increased (BAY 57-1293 IC50 = 12 nM, 20 nM and 50 nM; acyclovir IC50 = 1uM, 3M and 10 50 uM at a multiplicity of infection (m.o.i.) of 0.0025, 0.02 and 0.2, respectively). A minor increase in IC50 values at higher viral loads was observed for all thiazolyl compounds listed in Table 1. BAY 57-1293 was also active against porcine (IC50 = 5 uM) and bovine (IC50 = 0.12 uM) herpes strains [1].

In Vivo

Delayed treatment with BAY 57-1293 (20 mg/kg 2× daily per os, treatment day 4-14) abrogates progression of disease symptoms (mean of 10 animals per group) of HSV-2 infected guinea pigs within 1 d of treatment and healing is observed subsequently, whereas a 7.5 fold higher dose of valacyclovir (150 mg/kg 2× daily) shows marginal therapeutic efficacy compared with placebo [1]. The compound given orally, or intraperitoneally once per day at a dose of 15 mg/kg for 4 successive days was equally effective or superior to a much higher dose of famciclovir (1mg/ml, i.e. approximately 140-200mg/kg/day) given in the drinking water for 7 consecutive days, which, in our hands, is the most effective method for administering famciclovir to mice [2].

Clinical Trial
Molecular Weight

402.49

Formula

C₁₈H₁₈N₄O₃S₂

CAS No.

348086-71-5

SMILES

O=C(N(C1=NC(C)=C(S(=O)(N)=O)S1)C)CC2=CC=C(C3=NC=CC=C3)C=C2

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 33 mg/mL (81.99 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4845 mL 12.4227 mL 24.8453 mL
5 mM 0.4969 mL 2.4845 mL 4.9691 mL
10 mM 0.2485 mL 1.2423 mL 2.4845 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 98.38%

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