1. Anti-infection
  2. HSV
  3. Pritelivir mesylate hydrate

Pritelivir mesylate hydrate (Synonyms: BAY 57-1293 mesylate hydrate; AIC316 mesylate hydrate)

Cat. No.: HY-15303B
Handling Instructions

Pritelivir mesylate hydrate (BAY 57-1293 mesylate hydrate), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir mesylate hydrate is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC50 of 0.02 μM against HSV1-2.

For research use only. We do not sell to patients.

Pritelivir mesylate hydrate Chemical Structure

Pritelivir mesylate hydrate Chemical Structure

CAS No. : 1428321-10-1

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Description

Pritelivir mesylate hydrate (BAY 57-1293 mesylate hydrate), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir mesylate hydrate is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC50 of 0.02 μM against HSV1-2[1].

IC50 & Target

IC50: 0.02 μM (HSV1-2)[1]

In Vivo

Pritelivir is the first in a class of antiviral agents that inhibit HSV replication by targeting the viral helicase–primase enzyme complex[2].
Pritelivir (0.03-45 mg/kg) significantly increases survival. Pritelivir (0.3-30 mg/kg) reduces mortality against HSV-1, E-377. Pritelivir has potent and resistance-breaking antiviral efficacy with potential for the treatment of potentially life-threatening HSV type 1 and 2 infections, including herpes simplex encephalitis[3].
Combination therapies of Pritelivir at 0.1 or 0.3 mg/kg/dose with Acyclovir (10 mg/kg/dose) are protective when compared to the vehicle treated group against HSV-2, strain MS[3].

Animal Model: Female BALB/c mice[3]
Dosage: 0.03 to 45 mg/kg
Administration: Administered orally, twice daily at approximately 12 h intervals, for 7 days
Result: Survival was significantly increased to 80-100% as compared to the vehicle treatment. Even the lowest dose of 0.3 mg/kg was effective in increasing survival to 53%.
Molecular Weight

516.61

Formula

C₁₉H₂₄N₄O₇S₃

CAS No.

1428321-10-1

SMILES

O=C(N(C1=NC(C)=C(S(=O)(N)=O)S1)C)CC2=CC=C(C3=NC=CC=C3)C=C2.OS(=O)(C)=O.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Pritelivir mesylateBAY 57-1293 mesylateAIC316 mesylateHSVHerpes simplex virusviralhelicaseprimasecomplexherpesvirusHSV-1HSV-2Inhibitorinhibitorinhibit

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Pritelivir mesylate hydrate
Cat. No.:
HY-15303B
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