Encephalitis
Encephalitis is an inflammation of the brain caused by infections or immune system activation due to underlying medical conditions, presenting with a wide range of symptoms from mild flu-like illness to severe neurological deficits such as altered consciousness, confusion, seizures, hallucinations, speech and motor impairments, and coma. Common signs include fever, headache, stiff neck, vomiting, and in infants, lethargy, poor feeding, irritability, and bulging fontanel. Specific forms like herpetic encephalitis due to herpes simplex virus type 1 can cause rapid progression with fever, behavioral changes, memory loss, and paralysis, while mumps virus-induced encephalitis also contributes to neurological complications.
Références:
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Encephalitis (1)
GNF-2-deg
Cat. No.: HY-161804
- Formule: C37H33F3N6O9
- Masse moléculaire: 762.69
GNF-2-deg is a PROTAC degrader targeting the dengue virus envelope protein (DENV E protein), with a DC50 of 0.83 μM in Huh7.5 cells. GNF-2-deg induces CRBN- and proteasome-dependent proteolysis of intracellular E protein. GNF-2-deg inhibits E protein-mediated membrane fusion and blocks viral particle production. GNF-2-deg reduces viral yield in infected cells and retains activity against E protein βOG pocket mutant virus-like particles (VLP). GNF-2-deg can be used in the research of dengue virus infection, Zika virus infection, Japanese encephalitis, West Nile virus infection and yellow fever.
