IL-23 Receptor
The interleukin-23 receptor (IL-23R) is a type I transmembrane protein of the class I cytokine receptor family that confers specific responsiveness to IL-23. It consists of an extracellular region with a fibronectin type III domain and an Ig-like domain harboring the WSXWS motif, and a cytoplasmic tail with box 1/box 2 motifs and three tyrosine residues docking STAT4 and STAT3. IL-23R pairs with IL-12Rβ1 to form the functional receptor; IL-23 binding to IL-23R activates JAK2, while IL-12Rβ1 recruits TYK2. IL-23R is expressed on Th17 cells, Tregs, γδ T cells, NK cells, monocytes, macrophages and dendritic cells. Genome-wide association studies identify IL-23R variants (e.g., Arg381Gln) as strong protective or risk factors for Crohn's disease, ulcerative colitis, psoriasis and ankylosing spondylitis, underscoring its central role in IL-23-driven autoimmunity and therapeutic targeting.
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IL-23 Receptor Recombinant Proteins (13)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
