IL-23R Protein, Mouse (HEK293, Fc)

IL-23R protein and IL12RB1 form interleukin 23 receptor, which is the key binding site of IL23. IL-23R mediates stimulation of T cells, NK cells, and possibly macrophages/myeloid cells, activating the Jak-Stat signaling cascade. IL-23R Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived IL-23R protein, expressed by HEK293 , with C-hFc labeled tag.

The IL-23R Protein forms the interleukin-23 receptor in association with IL12RB1. Acting as a binding site for IL23, this receptor mediates stimulation in T-cells, NK cells, and possibly certain macrophage/myeloid cells, likely through the activation of the Jak-Stat signaling cascade. IL-23R plays a crucial role in both innate and adaptive immunity and may contribute to the acute response to infection in peripheral tissues. Additionally, IL-23R has been implicated in autoimmune inflammatory diseases and is thought to be significant in tumorigenesis. Operating as a heterodimer with IL12RB1, the IL-23R complex, when exposed to IL23, forms the functional IL23 receptor. Furthermore, IL-23R interacts with JAK2 and, in the presence of IL23, associates with STAT3, contributing to downstream signaling processes (By similarity).

Measured by its binding ability in a functional ELISA. When Recombinant Mouse IL-23R is present at 5 μg/mL, can bind Recombinant Mouse IL-23 Protein. The ED₅₀ for this effect is 20.81 ng/mL.

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  Measured by its binding ability in a functional ELISA. When Recombinant Mouse IL-23R is present at 5 μg/mL, can bind Recombinant Mouse IL-23 Protein .The ED₅₀ for this effect is 20.81 ng/mL.

Mouse

HEK293

C-hFc

Q8K4B4 (G24-D372)

209590  [NCBI]

Extracellular Domain

GITSINCSGDMWVEPGEIFQMGMNVSIYCQEALKHCRPRNLYFYKNGFKEEFDITRINRTTARIWYKGFSEPHAYMHCTAECPGHFQETLICGKDISSGHPPDAPSNLTCVIYEYSGNMTCTWNTGKPTYIDTKYIVHVKSLETEEEQQYLASSYVKISTDSLQGSRKYLVWVQAVNSLGMENSQQLHVHLDDIVIPSASIISRAETTNDTVPKTIVYWKSKTMIEKVFCEMRYKTTTNQTWSVKEFDANFTYVQQSEFYLEPDSKYVFQVRCQETGKRNWQPWSSPFVHQTSQETGKRNWQPWSSPFVHQTSQTVSQVTAKSSHEPQKMEMLSATIFRGHPASGNHQD

Approximately 90-110 kDa due to the glycosylation.

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  ≥ 90%, as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.