Il23r - interleukin 23 receptor Gene

Predicted to enable cytokine binding activity and interleukin-23 receptor activity. Predicted to contribute to interleukin-12 receptor binding activity and interleukin-23 binding activity. Predicted to be involved in several processes, including positive regulation of defense response to virus by host; regulation of cytokine production; and response to interferon-gamma. Predicted to act upstream of or within leukocyte mediated immunity and receptor signaling pathway via JAK-STAT. Predicted to be integral component of plasma membrane. Predicted to be part of interleukin-23 receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); inflammatory bowel disease (multiple); pulmonary hypertension; rhinitis; and systemic scleroderma. Orthologous to human IL23R (interleukin 23 receptor). [provided by Alliance of Genome Resources, Apr 2022]