1. Recombinant Proteins
  2. Immune Checkpoint Proteins
  3. Stimulatory Immune Checkpoint Molecules
  4. B7-H6

B7-H6, also known as NCR3LG1 or DKFZp686O24166, a member of the B7 family of immunoreceptors, is a type I transmembrane protein that shows considerable homology with the B7-H1 and B7-H3 proteins. B7-H6 is a co-stimulatory ligand for the natural cytotoxicity triggering receptor 3 (NKp30)-activating receptor expressed on natural killer cells. B7-H6 binds to NKp30, which initiates innate immune responses for cellular transformation. B7-H6 is not expressed in normal human tissues; however, its expression can be detected in various human malignancies including lymphoma, leukemia, melanoma, and carcinoma as well as on primary tumor blood cells. Therefore, B7-H6 could be considered as an excellent biomarker for several cancer types.

Cat. No. Product Name / Synonyms Species Source
  • HY-P72839
    B7-H6 Protein, Human (HEK293, Fc)

    Natural cytotoxicity triggering receptor 3 ligand 1; B7-H6; NCR3LG1

    Human HEK293
    B7-H6, a distinctive monomeric protein, uniquely triggers NCR3-dependent natural killer (NK) cell activation, specifically interacting with NCR3 while avoiding engagement with other NK cell-activating receptors (NCR1, NCR2, and KLRK1). This specificity underscores B7-H6's unique role in initiating NK cell responses through the NCR3 pathway within the intricate network of NK cell activation mechanisms. B7-H6 Protein, Human (HEK293, Fc) is the recombinant human-derived B7-H6 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of B7-H6 Protein, Human (HEK293, Fc) is 262 a.a., with molecular weight of ~53.4 kDa.
  • HY-P7631
    B7-H6 Protein, Human (HEK293, His)

    rHuB7-H6, His; B7 homolog 6; B7-H6; NCR3LG1; Natural cytotoxicity triggering receptor 3 ligand 1

    Human HEK293
    B7-H6 Protein, Human (HEK293, His) suppresses the initiation of the “caspase cascade” and induces anti-apoptosis by STAT3 pathway activation to provoke tumorigenesis.
  • HY-P78076
    B7-H6 Protein, Human (Biotinylated, HEK293, His-Avi)

    B7H6; B7-H6; DKFZp686I21167; DKFZp686O24166; NCR3LG1; B7 Homolog 6

    Human HEK293
    B7-H6, a distinctive monomeric protein, uniquely triggers NCR3-dependent natural killer (NK) cell activation, specifically interacting with NCR3 while avoiding engagement with other NK cell-activating receptors (NCR1, NCR2, and KLRK1). This specificity underscores B7-H6's unique role in initiating NK cell responses through the NCR3 pathway within the intricate network of NK cell activation mechanisms. B7-H6 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived B7-H6 protein, expressed by HEK293 , with C-His, C-Avi labeled tag. The total length of B7-H6 Protein, Human (Biotinylated, HEK293, His-Avi) is 238 a.a., with molecular weight of 48-65 kDa.
  • HY-P75484
    B7-H6 Protein, Rat (HEK293, Fc)

    Natural cytotoxicity triggering receptor 3 ligand 1; B7-H6; NCR3LG1

    Rat HEK293
    B7-H6, a distinctive monomeric protein, uniquely triggers NCR3-dependent natural killer (NK) cell activation, specifically interacting with NCR3 while avoiding engagement with other NK cell-activating receptors (NCR1, NCR2, and KLRK1). This specificity underscores B7-H6's unique role in initiating NK cell responses through the NCR3 pathway within the intricate network of NK cell activation mechanisms. B7-H6 Protein, Rat (HEK293, Fc) is the recombinant rat-derived B7-H6 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of B7-H6 Protein, Rat (HEK293, Fc) is 308 a.a., with molecular weight of ~60.4 kDa.
  • HY-P76742
    B7-H6 Protein, Cynomolgus (HEK293, Fc)

    Natural cytotoxicity triggering receptor 3 ligand 1; B7-H6; NCR3LG1

    Cynomolgus HEK293
    B7-H6 Protein is a member of B7 family that serves as a trigger for NCR3-dependent natural killer (NK) cell activation. Operating as a monomer, B7-H6 exhibits a specific interaction with NCR3, distinctly avoiding engagement with other NK cell-activating receptors. In addition, B7-H6 promotes tumorigenesis via apoptosis inhibition, proliferation and immunological progression. B7-H6 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived B7-H6 protein, expressed by HEK293 , with C-hFc labeled tag.
  • HY-P75483
    B7-H6 Protein, Rat (HEK293, His)

    Natural cytotoxicity triggering receptor 3 ligand 1; B7-H6; NCR3LG1

    Rat HEK293
    B7-H6, a distinctive monomeric protein, uniquely triggers NCR3-dependent natural killer (NK) cell activation, specifically interacting with NCR3 while avoiding engagement with other NK cell-activating receptors (NCR1, NCR2, and KLRK1). This specificity underscores B7-H6's unique role in initiating NK cell responses through the NCR3 pathway within the intricate network of NK cell activation mechanisms. B7-H6 Protein, Rat (HEK293, His) is the recombinant rat-derived B7-H6 protein, expressed by HEK293 , with C-His labeled tag.
  • HY-P76743
    B7-H6 Protein, Cynomolgus (HEK293, His)

    Natural cytotoxicity triggering receptor 3 ligand 1; B7-H6; NCR3LG1

    Cynomolgus HEK293
    B7-H6 Protein is a member of B7 family that serves as a trigger for NCR3-dependent natural killer (NK) cell activation. Operating as a monomer, B7-H6 exhibits a specific interaction with NCR3, distinctly avoiding engagement with other NK cell-activating receptors. In addition, B7-H6 promotes tumorigenesis via apoptosis inhibition, proliferation and immunological progression. B7-H6 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived B7-H6 protein, expressed by HEK293 , with C-His labeled tag.
Cat. No. Product Name Effect Purity