Lipid Nanoparticles (LNP) Encapsulation Service

MCE offers one-stop lipid nanoparticle (LNP) formulation services, professionally supporting the delivery of mRNAs, circular RNAs (circRNAs), self-amplifying RNAs (saRNAs), siRNAs, sgRNAs, and DNAs. Leveraging optimized lipid formulations and precision-targeted ligands, MCE ensures efficient, stable delivery of payloads to target tissues and cells, providing reliable technical support and solutions for your R&D projects.

Furthermore, MCE provides the full workflow covering gene synthesis, plasmid preparation, linearization, IVT RNA production, and LNP encapsulation, significantly shortening development timelines and reducing project costs, helping you accelerate the project progress.

For small-molecule compounds, MCE also provides customized LNP formulation services, with tailored solutions developed based on a professional assessment of each compound's structure and physicochemical properties. Representative applications include doxorubicin hydrochloride liposomes and paclitaxel liposomes, addressing diverse drug delivery needs.

Optional Formulations
  • Ionizable lipid formulations: MC3-LNP / SM102-LNP / ALC0315-LNP
  • Organ targeted LNPs: lung, spleen, liver, kidney and heart, etc
  • other customized LNPs
QC Testing
  • Appearance
  • Concentration
  • Encapsulation efficiency
  • Size distribution (POI)
  • polydispersity index (PDI)
  • Zeta potential
  • pH
  • Endotoxin
Optional Payloads
  • 20 nt-20 kb mRNA, siRNA, miRNA, circRNA, saRNA and DNA, etc
  • Small molecule compounds
Shipping/Storage
  • Liquid delivery (some of the products available in the form of freeze-dried powder)
  • Shipping with dry ice
  • Avoid freeze–thaw cycles

Popular Liposomes & LNPs catalogs available now!

Try our ready-to-use liposomes & LNPs pre-loaded with mRNA, or active compounds.

Cat. No. Product Name
HY-153229 Firefly luciferase mRNA-LNP
HY-153232 eGFP circRNA-LNP
HY-153235 COVID-19 Spike Protein mRNA-LNP
HY-153230 Firefly luciferase circRNA-LNP
HY-153231A eGFP mRNA-LNP (500 ng/μL)
HY-172202 Clodronate liposomes
Cat. No. Product Name
HY-185370 Doxorubicin liposome
HY-185373 Paclitaxel liposome
HY-177846 Liposomal Melatonin
HY-177843 Liposomal NMN
HY-177829 Liposomal Vitamin C
HY-177839 Liposomal Coenzyme Q10

Service and Consulting

The corresponding scheme and price for LNP formulation services shall be determined after evaluation. For further information on service prices or technical details, please send an email to sales [email protected] or contact MedChemExpress sales staff directly.

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  • * Payloads
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  • * LNP Formulations
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    • 1.Formula Optimization: Adjust the targeted organ of LNP by modifying the lipid components.
    • 2.Antibody or peptide conjugate LNPs: Adjust the targeted organ of LNP by conjugating antibodies or peptides.
    • 3.You can choose any one from General LNPs, Formulation-optimized LNPs, or Ligand-conjugated LNPs according to the experiment.
    • 4.If other LNPs are required, please provide specific formulation details for evaluation in the Other LNP Information section.

  • Default Detection Item

    • • pH
    • • Partical Size (PSD)
    • • Polydispersity Index (PDI)
    • • Encapsulation Efficiency
    • • Zeta Potential
    • • Payload Content

  • More Detections (extra charge)

  • The formulation of the no-load LNP is same as that of the encapsulated LNP

  • MCE Japan Authorized Agent: