2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. Liposome Estrogen Receptor/ERR
  4. Paclitaxel liposome

Paclitaxel liposome  (Synonyms: Liposomal paclitaxel)

Cat. No.: HY-185373
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Paclitaxel liposome (Liposomal paclitaxel) is an antitumor agent targeting Estrogen Receptor. Paclitaxel liposome binds to overexpressed Estrogen Receptor to mediate receptor-specific endocytosis, and enters cells via macropinocytosis, caveolae-dependent and clathrin-dependent endocytic pathways. Paclitaxel liposome suppresses cell viability and tumor growth, and reduces the distribution of Paclitaxel (HY-B0015) in normal tissues. Paclitaxel liposome can be used for research related to breast cancer and locally advanced esophageal squamous cell carcinoma.

For research use only. We do not sell to patients.

Paclitaxel liposome

Paclitaxel liposome Chemical Structure

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Paclitaxel liposome Related Antibodies

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

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Description

Paclitaxel liposome (Liposomal paclitaxel) is an antitumor agent targeting Estrogen Receptor. Paclitaxel liposome binds to overexpressed Estrogen Receptor to mediate receptor-specific endocytosis, and enters cells via macropinocytosis, caveolae-dependent and clathrin-dependent endocytic pathways. Paclitaxel liposome suppresses cell viability and tumor growth, and reduces the distribution of Paclitaxel (HY-B0015) in normal tissues. Paclitaxel liposome can be used for research related to breast cancer and locally advanced esophageal squamous cell carcinoma[1][2].

IC50 & Target[1]

Estrogen receptor

 

In Vitro

Paclitaxel liposome (L-PTX) (0.1-5000 ng/mL; 24-72 h) exerts potent, time- and concentration-dependent cytotoxicity against human breast cancer MCF-7 cells, with an IC50 of 11.54 ng/mL after 72 h of treatment[1].
Paclitaxel liposome (5 μg/mL RhB; 1-4 h, tracked via rhodamine B labeling) is taken up by human breast cancer MCF-7 cells, with lower uptake efficiency than targeted long-acting paclitaxel liposomes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Paclitaxel liposome Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: human breast cancer MCF-7 cells
Concentration: 0.1, 1, 10, 100, 500, 1000, 5000 ng/mL
Incubation Time: 24 h; 48 h; 72 h
Result: Showed concentration- and time-dependent inhibitory effects on MCF-7 cells.
Failed to achieve an IC50 after 24 h of treatment.
Reached an IC50 of 2095 ng/mL after 48 h of treatment.
Reached an IC50 of 11 ng/mL after 72 h of treatment.
In Vivo

Paclitaxel liposome (L-PTX) (5 mg/kg; i.v.; once every 2 days; 4 consecutive administrations) inhibits MCF-7 breast tumor growth in nude mice[1].
Paclitaxel liposome (10 mg/kg; i.v.; single dose) moderately prolongs Paclitaxel (HY-B0015) circulation time in healthy ICR mice, with an elimination half-life of 2.26 h and 1.38-fold higher bioavailability than free paclitaxel[1].
The common paclitaxel liposome (L-PTX) (80-200 mg/kg; i.v.; single dose) has reduced acute toxicity in healthy ICR mice, with an LD50 of 134.46 mg/kg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude (female, 16-18 g, inoculated with MCF-7 human breast cancer cells)[1]
Dosage: 5 mg/kg (based on paclitaxel content)
Administration: i.v.; once every 2 days; 4 consecutive administrations
Result: Reached mean tumor volume of 1000 mm3 after 18 days of administration.
Reached mean tumor volume of 1700 mm3 after 34 days of administration.
Showed gradual increase in body weight throughout the study period.
Appearance

Solid

Color

White to off-white

SMILES

[Paclitaxel liposome]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at 4°C, do not freeze
Purity & Documentation
References
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Paclitaxel liposome Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Paclitaxel liposomeLiposomal paclitaxelLiposomeEstrogen Receptor/ERRcaveolin-dependent endocytosisclathrin-dependent endocytosisbreast cancerlocally advanced esophageal squamous cell carcinomaMCF-7 cellsnude miceestrogen receptorICR micemacropinocytosisInhibitorinhibitorinhibit

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