Paclitaxel liposome
Based on 1 Customer Validation
Paclitaxel liposome (Liposomal paclitaxel) is an antitumor agent targeting Estrogen Receptor. Paclitaxel liposome binds to overexpressed Estrogen Receptor to mediate receptor-specific endocytosis, and enters cells via macropinocytosis, caveolae-dependent and clathrin-dependent endocytic pathways. Paclitaxel liposome suppresses cell viability and tumor growth, and reduces the distribution of Paclitaxel (HY-B0015) in normal tissues. Paclitaxel liposome can be used for research related to breast cancer and locally advanced esophageal squamous cell carcinoma.
For research use only. We do not sell to patients.
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Estrogen receptor |
Paclitaxel liposome (L-PTX) (0.1-5000 ng/mL; 24-72 h) exerts potent, time- and concentration-dependent cytotoxicity against human breast cancer MCF-7 cells, with an IC50 of 11.54 ng/mL after 72 h of treatment[1].
Paclitaxel liposome (5 μg/mL RhB; 1-4 h, tracked via rhodamine B labeling) is taken up by human breast cancer MCF-7 cells, with lower uptake efficiency than targeted long-acting paclitaxel liposomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human breast cancer MCF-7 cells
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Concentration:0.1, 1, 10, 100, 500, 1000, 5000 ng/mL
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Incubation Time:24 h; 48 h; 72 h
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Result:Showed concentration- and time-dependent inhibitory effects on MCF-7 cells.
Failed to achieve an IC50 after 24 h of treatment.
Reached an IC50 of 2095 ng/mL after 48 h of treatment.
Reached an IC50 of 11 ng/mL after 72 h of treatment.
Paclitaxel liposome (10 mg/kg; i.v.; single dose) moderately prolongs Paclitaxel (HY-B0015) circulation time in healthy ICR mice, with an elimination half-life of 2.26 h and 1.38-fold higher bioavailability than free paclitaxel[1].
The common paclitaxel liposome (L-PTX) (80-200 mg/kg; i.v.; single dose) has reduced acute toxicity in healthy ICR mice, with an LD50 of 134.46 mg/kg[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c nude (female, 16-18 g, inoculated with MCF-7 human breast cancer cells)[1]
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Dosage:5 mg/kg (based on paclitaxel content)
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Administration:i.v.; once every 2 days; 4 consecutive administrations
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Result:Reached mean tumor volume of 1000 mm3 after 18 days of administration.
Reached mean tumor volume of 1700 mm3 after 34 days of administration.
Showed gradual increase in body weight throughout the study period.
Chemical Information
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Appearance Solid
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Color White to off-white
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SMILES
[Paclitaxel liposome]
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Synonyms
Liposomal paclitaxel
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Han B, et al. Preparation, Characterization, and Pharmacokinetic Study of a Novel Long-Acting Targeted Paclitaxel Liposome with Antitumor Activity. Int J Nanomedicine. 2020;15:553-571. Published 2020 Jan 24. [Content Brief]
[2]. Yi Q, et al. Chemoradiotherapy with paclitaxel liposome plus cisplatin for locally advanced esophageal squamous cell carcinoma: A retrospective analysis. Cancer Med. 2023;12(6):6477-6487. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Paclitaxel liposome Related Classifications
HY-185373 Related Classifications
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