2. Lipids
  3. Lipids In Drug Delivery
  4. Lipid Nanoparticles

Lipid Nanoparticles

 

Lipid Nanoparticles (1326):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-134541
    SM-102 2089251-47-6 99.97%
    SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 has higher transfection efficiency. SM-102 plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines.
    SM-102
  • HY-N0322
    Cholesterol (from animal) 57-88-5 99.95%
    Cholesterol (from animal) is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol (from animal) plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins. Cholesterol (from animal) is also an endogenous estrogen-related receptor α (ERRα) agonist.
    Cholesterol (from animal)
  • HY-112251
    D-Lin-MC3-DMA 1224606-06-7 99.91%
    D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
    D-Lin-MC3-DMA
  • HY-W040193
    DSPC 816-94-4 99.95%
    DSPC (1,2-Distearoyl-sn-glycero-3-phosphorylcholine) is a cylindrical-shaped lipid. DSPC is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system.
    DSPC
  • HY-112764
    mPEG2000-DMG 160743-62-4 98.40%
    DMG-PEG 2000 is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG 2000 is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles.
    mPEG2000-DMG
  • HY-185370
    Doxorubicin liposome
    Doxorubicin liposome is a liposome-encapsulated form of doxorubicin hydrochloride (HY-15142). Doxorubicin hydrochloride, a cytotoxic anthracycline antibiotic, is a potent human DNA topoisomerase I and topoisomerase II inhibitor. Compared to traditional doxorubicin, liposome encapsulation reduces its cardiotoxicity and prolongs its circulation time, thus enabling it to effectively target tumor tissue.
    Doxorubicin liposome
  • HY-185373
    Paclitaxel liposome
    Paclitaxel liposome is a liposome-encapsulated form of Paclitaxel (HY-B0015). Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel liposome is characterized by reduced acute toxicity, prolonged circulating half-life of paclitaxel, and enhanced accumulation at tumor sites. Paclitaxel liposome can be used in research related to breast cancer and locally advanced esophageal squamous cell carcinoma.
    Paclitaxel liposome
  • HY-185399
    Vincristine sulfate liposome
    Vincristine sulfate liposome is?a liposome-encapsulated form of Vincristine sulfate (HY-N0488), an antitumor vinca alkaloid. Vincristine sulfate liposome can prolong the drug's circulation time in the body and release the drug slowly at the tumor blood vessels.
    Vincristine sulfate liposome
  • HY-138170
    ALC-0315 2036272-55-4 99.90%
    ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine.
    ALC-0315
  • HY-112005
    DOPE 4004-05-1 99.96%
    DOPE (Dioleoylphosphatidylethanolamine) is a neutral helper lipid for cationic liposome and combines with cationic phospholipids to improve transfection efficiency of naked siRNA.
    DOPE
  • HY-N0322A
    Cholesterol (Water Soluble) 98.0%
    Cholesterol Water Soluble is a major sterol in mammals, constituting 20-25% of the structural composition of the plasma membrane. The plasma membrane is highly permeable to water but relatively impermeable to ions and protons. Cholesterol Water Soluble plays an important role in determining the fluidity and permeability characteristics of membranes and the function of transporters and signaling proteins. Cholesterol Water Soluble is also an endogenous estrogen-related receptor alpha (ERRα) agonist. Cholesterol Water Soluble can be used to study the effects of cholesterol on potassium currents in inner hair cells.
    (Note: This product is a mixture of Cholesterol and Methyl-β-cyclodextrin. The product specifications below only indicate the effective content of Cholesterol.)
    Cholesterol (Water Soluble)
  • HY-112754A
    DOTAP chloride 132172-61-3 99.91%
    DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid.
    DOTAP chloride
  • HY-142979
    DSPE-PEG 2000 892144-24-0 99.95%
    DSPE-PEG 2000 is a PEG polymer containing DSPE and amine end groups. DSPE-PEG 2000 can be used to form micelles as nanoparticles for drug delivery.
    DSPE-PEG 2000
  • HY-N0171A
    Beta-Sitosterol (purity>98%) 83-46-5 99.74%
    Beta-Sitosterol (purity>98%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc.
    Beta-Sitosterol (purity>98%)
  • HY-125746
    BODIPY-Cholesterol 878557-19-8 99.77%
    BODIPY-cholesterol is an intrinsically lipophilic, and cell-permeable analog of cholesterol with a fluorescent BODIPY group. BODIPY-cholesterol can be used to monitor sterol uptake and inter-organelle sterol flux in cells. (Excitation/Emission: 505/515 nm).
    BODIPY-Cholesterol
  • HY-140739
    DSPE-PEG2000-Maleimide sodium (purity>95%) 99.58%
    DSPE-PEG2000-Maleimide sodium (purity>95%) is a phospholipid-PEG conjugate. DSPE-PEG2000-Maleimide utilizes the amphiphilicity of DSPE to insert into the lipid bilayer of liposomes or nanoparticles. DSPE-PEG2000-Maleimide covalently couples to the sulfhydryl (-SH) of ligands (such as antibodies, peptides, or proteins) via thiol-maleimide click chemistry, giving the particles targeting capabilities. DSPE-PEG2000-Maleimide sodium (purity>95%) can be used in the researches of breast cancer, lymphoma, and inherited retinal degeneration.
    DSPE-PEG2000-Maleimide sodium (purity>95%)
  • HY-109506
    DPPC 63-89-8 99.91%
    DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice.
    DPPC
  • HY-113424A
    1,2-Dioleoyl-sn-glycero-3-phosphocholine 4235-95-4 99.93%
    1,2-Dioleoyl-sn-glycero-3-phosphocholine (DOPC) is a phospholipid and is commonly used alone, or with other components, in the generation of micelles, liposomes, and other types of artificial membranes.
    1,2-Dioleoyl-sn-glycero-3-phosphocholine
  • HY-138300
    ALC-0159 1849616-42-7 99.93%
    ALC-0159, a polyethylene glycol (PEG) lipid conjugate, could be used as vaccine excipient.
    ALC-0159
  • HY-145405
    C12-200 1220890-25-4 99.91%
    C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B.
    C12-200