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Mitoxantrone dihydrochloride

(Synonyms: Mitozantrone dihydrochloride; NSC 301739 dihydrochloride)
48 Cited Publications
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Based on 48 publication(s) in Google Scholar

Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity. Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively.

For research use only. We do not sell to patients.

  • Purity: 98.98%
  • CAS No.: 70476-82-3
  • Formula: C22H30Cl2N4O6
  • Molecular Weight:517.40
  • Storage:

    4°C, sealed storage, away from moisture and light

    * In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture and light)

  • Mitoxantrone dihydrochloride Chemical Structure
    Mitoxantrone dihydrochloride Chemical Structure
  • Experimental Validation Results for Mitoxantrone dihydrochloride
  • Experimental Validation Results for Mitoxantrone dihydrochloride
  • Experimental Validation Results for Mitoxantrone dihydrochloride
  • Experimental Validation Results for Mitoxantrone dihydrochloride
  • Experimental Validation Results for Mitoxantrone dihydrochloride
CAS No.: 70476-82-3
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Cell Proliferation/Viability AssayApoptosis AnalysisIFWB
  • WB
  • Cell Proliferation/Viability Assay
  • Apoptosis Analysis
  • IF
  • WB

All Topoisomerase Isoforms

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All PKC Isoforms

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All Endogenous Metabolite Isoforms

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  • Mitoxantrone dihydrochloride Chemical Structure
    Mitoxantrone dihydrochloride Chemical Structure
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    Mitoxantrone dihydrochloride purchased from MedChemExpress. Usage Cited in: Exp Mol Med. 2025 Nov;57(11):2559-2573. [Abstract]

    Customer Validation
     The USP11 inhibitor Mitoxantrone (5-20 μM; 24 h) was treated to A549 (western blotting for EGFR) cells. The EGFR protein levels were assessed by western blotting using an anti-EGFR antibody.

  • 1/16

    Mitoxantrone dihydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2025 Aug 5;44(1):228. [Abstract]

    Customer Validation
     U87-MG and U251 cells with stable CSRP2 overexpression (CSRP2) were treated with or without 0.5 µM Mitoxantrone (MTO) for indicated time periods and the cell proliferation was analyzed. Cells transfected with control vector (NC) were used as a negative control. Two-way ANOVA with Sidak’s post hoc test, n = 6 per group for U87-MG and U251.

  • 1/16

    Mitoxantrone dihydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2025 Aug 5;44(1):228. [Abstract]

    Customer Validation
     U87-MG and U251 cells with stable CSRP2 overexpression were treated with 0.5 µM Mitoxantrone (MTO) for 48 h and cell apoptosis was measured by flow cytometry

  • 1/16

    Mitoxantrone dihydrochloride purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2024 Jun;26(6):917-931. [Abstract]

    Customer Validation
     HeLa cells were pre-treated with DMSO or Mitoxantrone (10 μM, 1 h) followed by Tg treatment (1 μM, 3 h).

  • 1/16

    Mitoxantrone dihydrochloride purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2024 Jun;26(6):917-931. [Abstract]

    Customer Validation
     HeLa cells were pre-treated with DMSO or Mitoxantrone (10 μM, 1 h) followed by Tg treatment (1 μM, 3 h).

  • Mitoxantrone dihydrochloride