PKC Inhibitors

PKC

PKCα

PKCβ

PKCγ

PKCδ

PKCε

PKCη

PKCζ

PKCθ

PKCμ

PKCι

PKC Inhibitors, Antagonists, Activators & Modulators

Product Name	PKC	PKCα	PKCβ	PKCγ	PKCδ	PKCε	PKCη	PKCζ	PKCθ	PKCμ	PKCι	Purity
Phorbol 12-myristate 13-acetate	PKC, EC₅₀: 11.7 nM											99.66%
Staurosporine	PKC, IC₅₀: 6 nM											99.98%
Go 6983		PKCα, IC₅₀: 7 nM	PKCβ, IC₅₀: 7 nM	PKCγ, IC₅₀: 6 nM	PKCδ, IC₅₀: 10 nM			PKCζ, IC₅₀: 60 nM		PKCμ, IC₅₀: 20000 nM		98.42%
PKCTheta-IN-1									PKCθ, IC₅₀: 0.1 nM
Mitoxantrone	PKC, IC₅₀: 8.5 μM											98.36%
Midostaurin		cPKC-α, IC₅₀: 22 nM	cPKC-β1, IC₅₀: 30 nM cPKC-β2, IC₅₀: 31 nM	cPKC-γ, IC₅₀: 24 nM	nPKC-δ, IC₅₀: 33 nM	nPKC-ε, IC₅₀: 1250 nM	nPKC-η, IC₅₀: 160 nM	aPKC-ζ, IC₅₀: 465000 nM				99.95%
Fasudil Hydrochloride	PKC, IC₅₀: 12.30 μM											99.96%
Bisindolylmaleimide I	Bovine brain PKC, IC₅₀: 10 nM	PKCα, IC₅₀: 20 nM	PKCβII, IC₅₀: 16 nM PKCβI, IC₅₀: 17 nM	PKCγ, IC₅₀: 20 nM								98.66%
Rottlerin		PKCα, IC₅₀: 30 μM (baculovirus-infected Sf9 insect cells)	PKCβ, IC₅₀: 42 μM (baculovirus-infected Sf9 insect cells)	PKCγ, IC₅₀: 40 μM (baculovirus-infected Sf9 insect cells)	PKCδ, IC₅₀: 3 μM (Porcine spleen)	PKCε, IC₅₀: 100 μM (baculovirus-infected Sf9 insect cells)	PKCη, IC₅₀: 82 μM (baculovirus-infected Sf9 insect cells)	PKCζ, IC₅₀: 100 μM (baculovirus-infected Sf9 insect cells)				98.15%
Sotrastaurin		PKCα, Ki: 0.95 nM	PKCβI, Ki: 0.64 nM		PKCδ, Ki: 2.1 nM	PKCε, Ki: 3.2 nM	PKCη, Ki: 1.8 nM		PKCθ, Ki: 0.22 nM			99.33%
Mitoxantrone dihydrochloride	PKC, IC₅₀: 8.5 μM											99.55%
Verbascoside	PKC, IC₅₀: 25 μM											99.83%
Chelerythrine chloride	PKC, IC₅₀: 660 nM											99.42%
Enzastaurin		PKCα, IC₅₀: 39 nM	PKCβ, IC₅₀: 6 nM	PKCγ, IC₅₀: 83 nM		PKCε, IC₅₀: 110 nM						99.92%
Afuresertib			PKC-βI, IC₅₀: 430 nM				PKCη, IC₅₀: 210 nM		PKCθ, IC₅₀: 510 nM			99.54%
Ingenol Mebutate		PKC-α, Ki: 0.3 nM	PKC-β, Ki: 0.105 nM	PKC-γ, Ki: 0.162 nM	PKC-δ, Ki: 0.376 nM	PKC-ε, Ki: 0.171 nM						99.41%
Ro 31-8220 mesylate	Rat Brain PKC, IC₅₀: 23 nM	PKC-α, IC₅₀: 5 nM	PKC-βI, IC₅₀: 24 nM PKC-βII, IC₅₀: 14 nM	PKC-γ, IC₅₀: 27 nM		PKC-ε, IC₅₀: 24 nM						99.28%
Darovasertib		PKCα, IC₅₀: 1.9 nM							PKCθ, IC₅₀: 0.4 nM			99.42%
DCP-LA						PKCε						≥98.0%
CGP60474	PKC											99.23%
Daphnetin	PKC, IC₅₀: 25.01 μM											99.86%
TPPB	PKC, Ki: 11.9 nM											99.81%
Ruboxistaurin		PKCα, IC₅₀: 360 nM	PKC-βI, IC₅₀: 4.7 nM PKC-βII, IC₅₀: 5.9 nM	PKCγ, IC₅₀: 300 nM	PKCδ, IC₅₀: 250 nM	PKCε, IC₅₀: 600 nM	PKCη, IC₅₀: 52 nM					99.90%
Valrubicin	TPA-activated PKC, IC₅₀: 0.85 μM PDBu-activated PKC, IC₅₀: 1.25 μM											99.60%
HA-100	PKC, IC₅₀: 12 μM PKC, Ki: 6.5 μM											99.80%
VTX-27		PKCα, Ki: 356 nM			PKCδ, Ki: 16 nM				PKCθ, Ki: 0.08 nM			99.64%
PKCβ inhibitor 1		PKCα, IC₅₀: 331 nM	human PKCβ1, IC₅₀: 21 nM human PKCβ2, IC₅₀: 5 nM									99.40%
CC-90005									PKCθ, IC₅₀: 8 nM			99.98%
BJE6-106		PKCα, IC₅₀: 50 μM			PKCδ, IC₅₀: 0.05 μM							99.93%
Ingenol	PKC, Ki: 30 μM											99.51%
Aurothiomalate sodium											PKCι	≥98.0%
Afuresertib hydrochloride			PKC-βI, IC₅₀: 430 nM				PKCη, IC₅₀: 210 nM		PKCθ, IC₅₀: 510 nM			99.03%
CMPD101		PKCα, IC₅₀: 8.1 μM										98.74%
Delcasertib hydrochloride					δPKC							99.86%
R 59-022	PKC											99.82%
PKC-theta inhibitor									PKCθ, IC₅₀: 12 nM			99.37%
PKC-IN-1		Human PKCα, IC₅₀: 2.3 nM Human PKCα, Ki: 10.4 nM	Human PKCβII, IC₅₀: 7.6 nM Human PKCβI, IC₅₀: 8.1 nM Human PKCβ, Ki: 5.3 nM	Human PKCγ, IC₅₀: 57.5 nM		Human PKCε, IC₅₀: 808 nM			Human PKCθ, IC₅₀: 25.6 nM	Human PKC mu, IC₅₀: 314 nM		98.79%
Prostratin	PKC, Ki: 12.5 nM											99.32%
ζ-Stat								aPKC-ζ, IC₅₀: 5 μM
Bisindolylmaleimide X hydrochloride	PKC											99.35%
N-Desmethyltamoxifen hydrochloride	PKC											99.93%
SB-218078	PKC, IC₅₀: 1000 nM											≥98.0%
Ruboxistaurin hydrochloride		PKCα, IC₅₀: 360 nM	PKCβI, IC₅₀: 4.7 nM PKCβII, IC₅₀: 5.9 nM	PKCγ, IC₅₀: 300 nM	PKCδ, IC₅₀: 250 nM	PKCε, IC₅₀: 600 nM	PKCη, IC₅₀: 52 nM					99.84%
R 59-022 hydrochloride	PKC											98.88%
TCS 21311		PKCα, IC₅₀: 13 nM							PKCθ, IC₅₀: 68 nM			99.18%
PKCiota-IN-2 formic		PKCα, IC₅₀: 71 nM				PKCε, IC₅₀: 350 nM					PKCι, IC₅₀: 2.8 nM	99.23%
PS432								PKCζ, IC₅₀: 18.5 μM			PKCι, IC₅₀: 16.9 μM	≥99.0%
C8-Ceramide	PKC											≥98.0%
PKC-theta inhibitor 1		PKCα, Ki: 1020 μM			PKCδ, Ki: 392 μM				PKCθ, Ki: 6 nM			99.73%
Protein kinase inhibitor H-7	PKC, Ki: 6 μM											99.97%
Bisindolylmaleimide XI hydrochloride		PKC-α, IC₅₀: 9 nM	PKC-βI, IC₅₀: 28 nM PKC-βII, IC₅₀: 31 nM	PKC-γ, IC₅₀: 37 nM		PKC-ε, IC₅₀: 108 nM						≥98.0%
DCPLA-ME						PKCε						≥98.0%
Bisindolylmaleimide I hydrochloride	Bovine brain PKC, IC₅₀: 10 nM	PKCα, IC₅₀: 20 nM	PKC-βII, IC₅₀: 16 nM PKC-βI, IC₅₀: 17 nM	PKCγ, IC₅₀: 20 nM								99.18%
Bisindolylmaleimide III		PKCα										98.95%
Bisindolylmaleimide IV	PKC, IC₅₀: 0.1-0.55 μM											99.62%
ML192			PKCβII
Ruboxistaurin mesylate		PKCα, IC₅₀: 360 nM	PKC-βI, IC₅₀: 4.7 nM PKC-βII, IC₅₀: 5.9 nM	PKCγ, IC₅₀: 300 nM	PKCδ, IC₅₀: 250 nM	PKCε, IC₅₀: 600 nM	PKCη, IC₅₀: 52 nM					99.87%
Psychosine	PKC											≥99.0%
CGP-53353			PKCβII, IC₅₀: 0.41 mM PKCβI, IC₅₀: 3.8 mM									98.87%
A-3 hydrochloride	PKC, Ki: 47 μM											99.75%
ζ-Stat trisodium								aPKC-ζ, IC₅₀: 5 μM
Chelerythrine	PKC, IC₅₀: 0.7 μM
Spisulosine								PKCζ				≥98.0%
CRT0066854 hydrochloride								PKCζ, IC₅₀: 639 nM				99.29%
TAS-301	PKC											99.61%
Delcasertib					δPKC							98.21%
(S)-Ro 32-0432		PKCα, IC₅₀: 9.3 nM	PKC-βI, IC₅₀: 28 nM PKC-βII, IC₅₀: 30 nM	PKCγ, IC₅₀: 36.5 nM		PKCε, IC₅₀: 108.3 nM
Bisindolylmaleimide VIII acetate	Rat Brain PKC, IC₅₀: 158 nM	PKC-α, IC₅₀: 53 nM	PKC-βI, IC₅₀: 195 nM PKC-βII, IC₅₀: 163 nM	PKC-γ, IC₅₀: 213 nM		PKC-ε, IC₅₀: 175 nM						99.70%
Fasudil	PKC, IC₅₀: 12.3 μM
Hu7691 free base							PKCη, IC₅₀: 629 nM
Hu7691							PKCη, IC₅₀: 629 nM
Fasudil dihydrochloride	PKC, IC₅₀: 12.3 μM
Mitoxantrone diacetate	PKC, IC₅₀: 8.5 μM
Fasudil hydrochloride semihydrate	PKC, IC₅₀: 12.3 μM
PKC-IN-4	PKC, IC₅₀: 0.52 μM
PKCiota-IN-2		PKCα, IC₅₀: 71 nM				PKCε, IC₅₀: 350 nM					PKCι, IC₅₀: 2.8 nM
N-Desmethyltamoxifen	PKC
HBDDE		PKCα, IC₅₀: 43 μM		PKCγ, IC₅₀: 50 μM
Sphingosine (d14:1)	PKC
PKC β pseudosubstrate			PKC-β									98.98%
CDK8-IN-12									PKCθ, Ki: 109 nM
PS315							PKCη, IC₅₀: 30 μM	PKCζ, IC₅₀: 10 μM
[Ala113]MBP(104-118)	PKC, IC₅₀: 28-62 μM
OSU-2S					PKCδ
PF-04577806		PKCα, IC₅₀: 2.4 nM	PKCβI, IC₅₀: 8.1 nM PKCβII, IC₅₀: 6.9 nM	PKCγ, IC₅₀: 45.9 nM	PKCδ, IC₅₀: 586 nM	PKCε, IC₅₀: 522 nM			PKCθ, IC₅₀: 29.5 nM
Leucosceptoside A		PKCα, IC₅₀: 19 μM
PKCδ Peptide Substrate					PKCδ
AS2521780		PKCα, IC₅₀: 160 nM			PKCδ, IC₅₀: 160 nM	PKCε, IC₅₀: 18 nM			PKCθ, IC₅₀: 0.48 nM
Aurora A/PKC-IN-1		PKCα, IC₅₀: 16.9 nM
HA-100 hydrochloride	PKC, IC₅₀: 12 μM
PF-03622905		PKCα, IC₅₀: 5.6 nM	PKCβI, IC₅₀: 14.5 nM PKCβII, IC₅₀: 13 nM	PKCγ, IC₅₀: 37.7 nM					PKCθ, IC₅₀: 74.1 nM
SB 220025	PKC, IC₅₀: 2.89 μM
[Ala107]MBP(104-118)	PKC, IC₅₀: 46-145 μM
HA-100 dihydrochloride	PKC, IC₅₀: 12 μM PKC, Ki: 6.5 μM
PKC β pseudosubstrate TFA			PKCβ
Balanol		Human PKCα, : 4-9 nM	PKC-βI, : 4-9 nM PKC-βII, : 4-9 nM	Human PKCγ, : 4-9 nM	Human PKCδ, : 4-9 nM	Human PKCε, : 4-9 nM	human PKCη, : 150 nM
[Ala113]MBP(104-118) TFA	PKC, IC₅₀: 28-62 μM
PF-4950834							PKCη, IC₅₀: 756 nM
PKCiota-IN-1		PKCα, IC₅₀: 45 nM				PKCε, IC₅₀: 450 nM					PKCι, IC₅₀: 2.7 nM
GSK-3β inhibitor 13									PKCθ, IC₅₀: 0.36 μM
[Ala107]MBP(104-118) TFA	PKC, IC₅₀: 46-145 μM

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