1. Signaling Pathways
  2. Epigenetics
    TGF-beta/Smad
  3. PKC
  4. PKC Inhibitors

PKC Inhibitors

PKC

PKCα

PKCβ

PKCγ

PKCδ

PKCε

PKCη

PKCζ

PKCθ

PKCμ

PKC-ι ℩

PKCι

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

PKC Inhibitors, Antagonists, Activators & Modulators
Product Name PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι Purity
Phorbol 12-myristate 13-acetate
PKC, EC50: 11.7 nM
                      99.80%
Staurosporine
PKC, IC50: 6 nM
                      99.98%
Go 6983  
PKCα, IC50: 7 nM
PKCβ, IC50: 7 nM
PKCγ, IC50: 6 nM
PKCδ, IC50: 10 nM
   
PKCζ, IC50: 60 nM
 
PKCμ, IC50: 20000 nM
    99.32%
Mitoxantrone
PKC, IC50: 8.5 μM
                      98.36%
Midostaurin  
cPKC-α, IC50: 22 nM
cPKC-β1, IC50: 30 nM
cPKC-β2, IC50: 31 nM
cPKC-γ, IC50: 24 nM
nPKC-δ, IC50: 33 nM
nPKC-ε, IC50: 1250 nM
nPKC-η, IC50: 160 nM
aPKC-ζ, IC50: 465000 nM
        99.95%
Fasudil Hydrochloride
PKC, IC50: 12.30 μM
                      99.96%
Bisindolylmaleimide I
Bovine brain PKC, IC50: 10 nM
PKCα, IC50: 20 nM
PKCβII, IC50: 16 nM
PKCβI, IC50: 17 nM
PKCγ, IC50: 20 nM
                98.66%
Rottlerin  
PKCα, IC50: 30 μM (baculovirus-infected Sf9 insect cells)
PKCβ, IC50: 42 μM (baculovirus-infected Sf9 insect cells)
PKCγ, IC50: 40 μM (baculovirus-infected Sf9 insect cells)
PKCδ, IC50: 3 μM (Porcine spleen)
PKCε, IC50: 100 μM (baculovirus-infected Sf9 insect cells)
PKCη, IC50: 82 μM (baculovirus-infected Sf9 insect cells)
PKCζ, IC50: 100 μM (baculovirus-infected Sf9 insect cells)
        98.09%
Sotrastaurin  
PKCα, Ki: 0.95 nM
PKCβI, Ki: 0.64 nM
 
PKCδ, Ki: 2.1 nM
PKCε, Ki: 3.2 nM
PKCη, Ki: 1.8 nM
 
PKCθ, Ki: 0.22 nM
      99.71%
Verbascoside
PKC, IC50: 25 μM
                      99.83%
Mitoxantrone dihydrochloride
PKC, IC50: 8.5 μM
                      99.55%
Enzastaurin  
PKCα, IC50: 39 nM
PKCβ, IC50: 6 nM
PKCγ, IC50: 83 nM
 
PKCε, IC50: 110 nM
            99.92%
D-erythro-Sphingosine
PKC
                      ≥98.0%
Chelerythrine chloride
PKC, IC50: 660 nM
                      99.42%
Afuresertib    
PKC-βI, IC50: 430 nM
     
PKCη, IC50: 210 nM
 
PKCθ, IC50: 510 nM
      99.54%
Ingenol Mebutate  
PKC-α, Ki: 0.3 nM
PKC-β, Ki: 0.105 nM
PKC-γ, Ki: 0.162 nM
PKC-δ, Ki: 0.376 nM
PKC-ε, Ki: 0.171 nM
            99.65%
CGP60474
PKC
                      99.23%
DCP-LA          
PKCε
            ≥98.0%
Daphnetin
PKC, IC50: 25.01 μM
                      99.86%
Ro 31-8220 mesylate
Rat Brain PKC, IC50: 23 nM
PKC-α, IC50: 5 nM
PKC-βI, IC50: 24 nM
PKC-βII, IC50: 14 nM
PKC-γ, IC50: 27 nM
 
PKC-ε, IC50: 24 nM
            99.28%
Darovasertib  
PKCα, IC50: 1.9 nM
           
PKCθ, IC50: 0.4 nM
      99.42%
TPPB
PKC, Ki: 11.9 nM
                      99.81%
CMPD101  
PKCα, IC50: 8.1 μM
                    98.95%
PKCβ inhibitor 1  
PKCα, IC50: 331 nM
human PKCβ1, IC50: 21 nM
human PKCβ2, IC50: 5 nM
                  99.40%
Valrubicin
TPA-activated PKC, IC50: 0.85 μM
PDBu-activated PKC, IC50: 1.25 μM
                      99.60%
Ruboxistaurin  
PKCα, IC50: 360 nM
PKC-βI, IC50: 4.7 nM
PKC-βII, IC50: 5.9 nM
PKCγ, IC50: 300 nM
PKCδ, IC50: 250 nM
PKCε, IC50: 600 nM
PKCη, IC50: 52 nM
          99.90%
CC-90005                
PKCθ, IC50: 8 nM
      99.98%
Epsilon-V1-2          
PKCε
           
HA-100
PKC, IC50: 12 μM
PKC, Ki: 6.5 μM
                      99.80%
Prostratin
PKC, Ki: 12.5 nM
                      99.32%
VTX-27  
PKCα, Ki: 356 nM
   
PKCδ, Ki: 16 nM
     
PKCθ, Ki: 0.08 nM
      99.64%
BJE6-106  
PKCα, IC50: 50 μM
   
PKCδ, IC50: 0.05 μM
              99.93%
R 59-022
PKC
                      99.82%
PKC-IN-1  
Human PKCα, IC50: 2.3 nM
Human PKCα, Ki: 10.4 nM
Human PKCβII, IC50: 7.6 nM
Human PKCβI, IC50: 8.1 nM
Human PKCβ, Ki: 5.3 nM
Human PKCγ, IC50: 57.5 nM
 
Human PKCε, IC50: 808 nM
   
Human PKCθ, IC50: 25.6 nM
Human PKC mu, IC50: 314 nM
    98.79%
Delcasertib hydrochloride        
δPKC
              99.86%
PKC-theta inhibitor                
PKCθ, IC50: 12 nM
      99.37%
Afuresertib hydrochloride    
PKC-βI, IC50: 430 nM
     
PKCη, IC50: 210 nM
 
PKCθ, IC50: 510 nM
      99.95%
KT5823
PKC, Ki: 4 μM
                      99.90%
Ingenol
PKC, Ki: 30 μM
                      99.51%
Aurothiomalate sodium                      
PKCι
≥98.0%
CRT0066854              
PKCζ, IC50: 639 nM
        99.59%
Bisindolylmaleimide X hydrochloride
PKC
                      99.35%
ζ-Stat              
aPKC-ζ, IC50: 5 μM
       
Ruboxistaurin hydrochloride  
PKCα, IC50: 360 nM
PKCβI, IC50: 4.7 nM
PKCβII, IC50: 5.9 nM
PKCγ, IC50: 300 nM
PKCδ, IC50: 250 nM
PKCε, IC50: 600 nM
PKCη, IC50: 52 nM
          99.84%
N-Desmethyltamoxifen hydrochloride
PKC
                      99.93%
SB-218078
PKC, IC50: 1000 nM
                      98.3%
PKC-theta inhibitor 1  
PKCα, Ki: 1020 μM
   
PKCδ, Ki: 392 μM
     
PKCθ, Ki: 6 nM
      99.73%
R 59-022 hydrochloride
PKC
                      98.88%
C8-Ceramide
PKC
                      ≥98.0%
PKCiota-IN-2 formic  
PKCα, IC50: 71 nM
     
PKCε, IC50: 350 nM
         
PKCι, IC50: 2.8 nM
99.23%
PS432              
PKCζ, IC50: 18.5 μM
     
PKCι, IC50: 16.9 μM
≥99.0%
Protein kinase inhibitor H-7
PKC, Ki: 6 μM
                      99.97%
TCS 21311  
PKCα, IC50: 13 nM
           
PKCθ, IC50: 68 nM
      99.18%
Bisindolylmaleimide XI hydrochloride  
PKC-α, IC50: 9 nM
PKC-βI, IC50: 28 nM
PKC-βII, IC50: 31 nM
PKC-γ, IC50: 37 nM
 
PKC-ε, IC50: 108 nM
            ≥98.0%
ML192    
PKCβII
                 
Ruboxistaurin mesylate  
PKCα, IC50: 360 nM
PKC-βI, IC50: 4.7 nM
PKC-βII, IC50: 5.9 nM
PKCγ, IC50: 300 nM
PKCδ, IC50: 250 nM
PKCε, IC50: 600 nM
PKCη, IC50: 52 nM
          99.87%
Psychosine
PKC
                      ≥99.0%
Bisindolylmaleimide I hydrochloride
Bovine brain PKC, IC50: 10 nM
PKCα, IC50: 20 nM
PKC-βII, IC50: 16 nM
PKC-βI, IC50: 17 nM
PKCγ, IC50: 20 nM
                99.18%
Bisindolylmaleimide III  
PKCα
                    98.95%
CRT0066854 hydrochloride              
PKCζ, IC50: 639 nM
        99.29%
Bisindolylmaleimide IV
PKC, IC50: 0.1-0.55 μM
                      99.62%
DCPLA-ME          
PKCε
            ≥98.0%
Bisindolylmaleimide VIII acetate
Rat Brain PKC, IC50: 158 nM
PKC-α, IC50: 53 nM
PKC-βI, IC50: 195 nM
PKC-βII, IC50: 163 nM
PKC-γ, IC50: 213 nM
 
PKC-ε, IC50: 175 nM
            99.68%
CGP-53353    
PKCβII, IC50: 0.41 mM
PKCβI, IC50: 3.8 mM
                  98.87%
A-3 hydrochloride
PKC, Ki: 47 μM
                      99.75%
ζ-Stat trisodium              
aPKC-ζ, IC50: 5 μM
       
Chelerythrine
PKC, IC50: 0.7 μM
                     
Spisulosine              
PKCζ
        ≥98.0%
Sphingosine (d14:1)
PKC
                      ≥99.0%
OSU-2S        
PKCδ
             
TAS-301
PKC
                      99.61%
Delcasertib        
δPKC
              98.21%
(S)-Ro 32-0432  
PKCα, IC50: 9.3 nM
PKC-βI, IC50: 28 nM
PKC-βII, IC50: 30 nM
PKCγ, IC50: 36.5 nM
 
PKCε, IC50: 108.3 nM
           
Fasudil
PKC, IC50: 12.3 μM
                     
Hu7691 free base            
PKCη, IC50: 629 nM
         
Hu7691            
PKCη, IC50: 629 nM
         
Fasudil dihydrochloride
PKC, IC50: 12.3 μM
                     
Mitoxantrone diacetate
PKC, IC50: 8.5 μM
                     
Fasudil hydrochloride semihydrate
PKC, IC50: 12.3 μM
                     
PKC-IN-4
PKC, IC50: 0.52 μM
                     
PKCiota-IN-2  
PKCα, IC50: 71 nM
     
PKCε, IC50: 350 nM
         
PKCι, IC50: 2.8 nM
N-Desmethyltamoxifen
PKC
                     
HBDDE  
PKCα, IC50: 43 μM
 
PKCγ, IC50: 50 μM
                98.03%
PKC β pseudosubstrate    
PKC-β
                  98.98%
CDK8-IN-12                
PKCθ, Ki: 109 nM
      99.74%
PS315            
PKCη, IC50: 30 μM
PKCζ, IC50: 10 μM
       
PKCTheta-IN-1                
PKCθ, IC50: 0.1 nM
     
[Ala113]MBP(104-118)
PKC, IC50: 28-62 μM
                     
PF-04577806  
PKCα, IC50: 2.4 nM
PKCβI, IC50: 8.1 nM
PKCβII, IC50: 6.9 nM
PKCγ, IC50: 45.9 nM
PKCδ, IC50: 586 nM
PKCε, IC50: 522 nM
   
PKCθ, IC50: 29.5 nM
     
Leucosceptoside A  
PKCα, IC50: 19 μM
                   
PKCδ Peptide Substrate        
PKCδ
             
AS2521780  
PKCα, IC50: 160 nM
   
PKCδ, IC50: 160 nM
PKCε, IC50: 18 nM
   
PKCθ, IC50: 0.48 nM
     
Aurora A/PKC-IN-1  
PKCα, IC50: 16.9 nM
                   
HA-100 hydrochloride
PKC, IC50: 12 μM
                     
PF-03622905  
PKCα, IC50: 5.6 nM
PKCβI, IC50: 14.5 nM
PKCβII, IC50: 13 nM
PKCγ, IC50: 37.7 nM
       
PKCθ, IC50: 74.1 nM
     
SB 220025
PKC, IC50: 2.89 μM
                     
[Ala107]MBP(104-118)
PKC, IC50: 46-145 μM
                     
HA-100 dihydrochloride
PKC, IC50: 12 μM
PKC, Ki: 6.5 μM
                     
PKC β pseudosubstrate TFA    
PKCβ
                 
[Ala113]MBP(104-118) TFA
PKC, IC50: 28-62 μM
                     
PF-4950834            
PKCη, IC50: 756 nM
         
PKCiota-IN-1  
PKCα, IC50: 45 nM
     
PKCε, IC50: 450 nM
         
PKCι, IC50: 2.7 nM
CIDD-0072424          
PKCε, Ki: 54 nM
           
GSK-3β inhibitor 13                
PKCθ, IC50: 0.36 μM
     
[Ala107]MBP(104-118) TFA
PKC, IC50: 46-145 μM
                     
Bisindolylmaleimide VIII
Rat Brain PKC, IC50: 158 nM
PKCα, IC50: 53 nM
PKC-βI, IC50: 195 nM
PKC-βII, IC50: 163 nM
PKCγ, IC50: 213 nM
 
PKCε, IC50: 175 nM
           
Balanol  
Human PKCα, : 4-9 nM
PKC-βI, : 4-9 nM
PKC-βII, : 4-9 nM
Human PKCγ, : 4-9 nM
Human PKCδ, : 4-9 nM
Human PKCε, : 4-9 nM
human PKCη, : 150 nM