2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. HGF & Receptors
  5. HGF

HGF

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Hepatocyte growth factor (HGF, also known as Scatter Factor) is among a group of factors possessing angiogenic ability. HGF was originally discovered as a fibroblast-derived cell motility factor for epithelial cells. It is synthesized by mesenchymal cells, fibroblasts, and smooth muscle cells. Active HGF is a heterodimer consists of a heavy chain (α chain, 62 kDa) and a light chain (β chain, 32-36 kDa), which are covalently linked by a disulfide bridge. HGF exerts its biological functions (i.e., proliferation/differentiation/survival/motogenesis) mediated by binding to the c-Met receptor. The HGF/c-Met signaling axis contributes in a paracrine manner to the development of epithelial organs, exerts regenerative effects on the epithelium, and promotes the regression of fibrosis in numerous organs. Additionally, the HGF/c-Met signaling pathway is correlated with the biology of cancer, neurons and immunity.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P7121
    HGF Protein, Human (CHO)

    rHuHGF; Hepatopoietin-A; SF

    		Human CHO
    HGF Protein, Human (CHO) is a cytokine binding to Met tyrosine kinase receptor, and exhibits biological activities.
  • HY-P73928
    HGF Protein, Mouse (HEK293)

    Hepatocyte growth factor; F-TCF; Hepatopoeitin-A; HGF; HGFB; HPTA; SF

    		Mouse HEK293
    HGF Protein, a potent mitogen, stimulates mature hepatocyte cell growth and acts as a hepatotrophic factor for various tissues. As an activating ligand for MET receptor tyrosine kinase, HGF binds and promotes dimerization, activating MAPK signaling through TMPRSS13 cleavage. Structurally, HGF comprises alpha and beta chains connected by a disulfide bond. Interaction with SRPX2 enhances its mitogenic activity. HGF Protein, Mouse (HEK293) is the recombinant mouse-derived HGF protein, expressed by HEK293 , with tag free. The total length of HGF Protein, Mouse (HEK293) is 696 a.a., with molecular weight of ~93 kDa.
  • HY-P70627
    HGF Protein, Human (HEK293, His)

    Hepatocyte growth factor; HPTA; HGF; SF; Scatter factor; Hepatopoietin-A

    		Human HEK293
    HGF Protein is a hepatocyte growth factor involved in signaling pathways including MET and MAPK. The HGF Protein consists of 728 amino acids, with an alpha chain containing an n-terminal domain four kringle domains, and a β serine protease domain. HGF Protein, Human (HEK293, His) is the recombinant human-derived HGF protein, expressed by HEK293 , with C-His labeled tag. The total length of HGF Protein, Human (HEK293, His) is 697 a.a., with molecular weight of 32-36 & 52 & 80-100 kDa, respectively.
  • HY-P70561
    HGF Protein, Mouse (696a.a, HEK293, His)

    Hepatopoietin-A; Scatter factor; SF; deafness, autosomal recessive 39; DFNB39; F-TCF; hepatocyte growth factor; HGF

    		Mouse HEK293
    HGF Protein, a potent mitogen, stimulates mature hepatocyte cell growth and acts as a hepatotrophic factor for various tissues. As an activating ligand for MET receptor tyrosine kinase, HGF binds and promotes dimerization, activating MAPK signaling through TMPRSS13 cleavage. Structurally, HGF comprises alpha and beta chains connected by a disulfide bond. Interaction with SRPX2 enhances its mitogenic activity. HGF Protein, Mouse (696a.a, HEK293, His) is the recombinant mouse-derived HGF protein, expressed by HEK293 , with C-6*His labeled tag. The total length of HGF Protein, Mouse (696a.a, HEK293, His) is 696 a.a., with molecular weight of (50-90) & (30-34) kDa, respectively.
  • HY-P73101
    HGF Protein, Rat (HEK293)

    Hepatocyte growth factor; F-TCF; Hepatopoeitin-A; HGF; HGFB; HPTA; SF

    		Rat HEK293
    The HGF gene encodes hepatocyte growth factor (HGF), a protein involved in organ regeneration, angiogenesis, and myelination. It is located in the extracellular space and serves as a biomarker for cholangiocarcinoma. Implicated in various diseases, HGF plays a crucial role in physiological and pathological conditions. It shows biased expression in the liver (RPKM 137.5), lung (RPKM 132.1), and other tissues. HGF Protein, Rat (HEK293) is the recombinant rat-derived HGF protein, expressed by HEK293 , with tag free. The total length of HGF Protein, Rat (HEK293) is 696 a.a., with molecular weight of ~92 kDa.
  • HY-P75809
    HGF Protein, Cynomolgus (HEK293)

    Hepatocyte growth factor; F-TCF; Hepatopoeitin-A; HGF; HGFB; HPTA; SF

    		Cynomolgus HEK293
    HGF Protein, a potent mitogen, stimulates mature hepatocyte growth and exhibits hepatotrophic properties for various tissues. It acts as an activating ligand for the receptor tyrosine kinase MET, promoting dimerization upon binding. Structurally, HGF Protein comprises alpha and beta chains linked by a disulfide bond. Additionally, it interacts with SRPX2, enhancing HGF's mitogenic activity. HGF Protein, Cynomolgus (HEK293) is the recombinant cynomolgus-derived HGF protein, expressed by HEK293 , with tag free. The total length of HGF Protein, Cynomolgus (HEK293) is 728 a.a., with molecular weight of ~89 & 58 & 34 & 32 kDa, respectively.
  • HY-P71688
    HGF Protein, Rat (GST)

    Hgf; Hepatocyte growth factor; Hepatopoietin-A

    		Rat E. coli
    HGF Protein, a potent mitogen, stimulates mature hepatocyte cell growth, acting as a hepatotrophic factor for various tissues. It activates MAPK signaling through TMPRSS13 cleavage and activates MET receptor tyrosine kinase by promoting its dimerization. Structurally, HGF comprises alpha and beta chains connected by a disulfide bond. Interaction with SRPX2 enhances its mitogenic activity. HGF Protein, Rat (GST) is the recombinant rat-derived HGF protein, expressed by E. coli , with N-GST labeled tag. The total length of HGF Protein, Rat (GST) is 252 a.a., with molecular weight of ~55.0 kDa.
  • HY-P74889
    HGF Protein, Canine (HEK293)

    Hepatocyte growth factor; F-TCF; Hepatopoeitin-A; HGF; HGFB; HPTA; SF

    		Canine HEK293
    HGF protein is a potent hepatocyte mitogen that stimulates mature hepatocyte proliferation and exhibits multiple growth factor properties in different tissues. As a ligand of MET receptor tyrosine kinase, HGF initiates downstream signaling cascades upon binding, activating MAPK signaling after TMPRSS13 cleavage. HGF Protein, Canine (HEK293) is the recombinant canine-derived HGF protein, expressed by HEK293 , with tag free. The total length of HGF Protein, Canine (HEK293) is 699 a.a., with molecular weight of ~79.9 kDa.
  • HY-P70627G
    GMP HGF Protein, Human (HEK293, His)

    Hepatocyte growth factor; HPTA; HGF; SF; Scatter factor; Hepatopoietin-A

    		Human HEK293
    HGF Protein, a potent mitogen, stimulates mature hepatocyte cell growth and exhibits hepatotrophic properties. It acts as a growth factor for diverse tissues, functioning as an activating ligand for MET receptor tyrosine kinase. Upon binding, HGF promotes MET dimerization, activating the MAPK signaling cascade via TMPRSS13 cleavage. Structurally, HGF comprises alpha and beta chains linked by a disulfide bond. Interaction with SRPX2 enhances its mitogenic activity. GMP HGF Protein, Human (HEK293, His) is the recombinant human-derived HGF protein, expressed by HEK293, with C-6*His labeled tag. The total length of GMP HGF Protein, Human (HEK293, His) is 697 a.a., with molecular weight of 32-38 & 50-65 kDa, respectively.
Cat. No. Product Name Effect Purity