OSM Receptor
The oncostatin M receptor (OSMR) is the specific 972-amino-acid type I transmembrane subunit that combines with gp130 (CD130) to form the high-affinity receptor for oncostatin M, a gp130-family cytokine produced by activated T cells, macrophages and neutrophils. OSMR is also shared with the IL-31 receptor, pairing with IL-31RA. The cytoplasmic domain of OSMR carries tyrosine-based docking sites recruiting JAK1 and STAT3/STAT5, enabling OSM to activate MAPK and PI3K in addition to JAK-STAT cascades. OSMR is expressed on hepatocytes, neural cells, endothelial cells, fibroblasts, osteoblasts and keratinocytes. OSM-OSMR signaling drives acute-phase protein synthesis, liver regeneration, hematopoiesis, bone remodeling, nociceptive neuron sensitization and inflammatory pain. Pathologically, OSMR signaling is strongly implicated in arthritis, inflammatory bowel disease and cutaneous scleroderma/fibrosis via fibroblast activation, making OSMR an emerging antifibrotic target.
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OSM Receptor Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
