OSMR beta Protein, Cynomolgus (HEK293, His)

OSMR beta protein is a type I cytokine receptor in the type 2 subfamily and is critical in cell signaling and immune responses. OSMR beta serves as a receptor for oncostatin M, a cytokine that plays a role in inflammation, cell growth, and differentiation, and is critical for downstream signaling and regulation of cell function. OSMR beta Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived OSMR beta protein, expressed by HEK293 , with C-His labeled tag.

The OSMR beta protein belongs to the type I cytokine receptor family, specifically the type 2 subfamily. This protein plays a significant role in cellular signaling and immune responses. It acts as a receptor for oncostatin M, a cytokine involved in various biological processes such as inflammation, cell growth, and differentiation. The OSMR beta protein is essential for the activation of downstream signaling pathways and the regulation of cellular functions. Understanding the function and regulation of OSMR beta protein can provide valuable insights into the development of therapeutic strategies for diseases involving dysregulation of cytokine signaling or immune responses.

Immobilized Cynomolgus OSMR, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Anti-OSMR Antibody, hFc Tag with the EC₅₀ of 6.1-7.1ng/mL determined by ELISA.

Cynomolgus

HEK293

C-8*His

A0A2K5UFW5 (E28-S737)

102135082

Extracellular Domain

ERLPLTPVSLKVSTNSIHQSLHLQWTVHNLPYHQELKMVFQIQISRIETSNVVWVGNYSTPVKWNQVLHWSWESELPLECATHFVRIKSVIDDASFPEPNFWSNWSSWEEVSVQDYLGRGTLFVFPKDKLVEEGSNVTICYVSRNIQNNVSCYLEGKQIHGEQLDPHVTAFNLNSVPFIRNRGTNIYCEASQGNVSKGIEGIVLFVSKVLEEPKDFSCESQDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQDSQEMYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSMRNNFTYLCQIELHGEGKMMQQYDVSINVNGEYFLSELEPATEYMARVRCADASHFWKWTEWSGQNFTTLEAAPSEAPDVWRSVNSEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSRSELRSIPAPANSTKLILDRCSYQICVTANNSVGASPASIIVISADPENKEVEEERIAGTEGGFSLSWKPQPGDVIGYVVDWCDHPQDVLQWKNVGPNTTSTVISTDAFRPGVRYDFRIYGLSTKRIACLLEKKTGYSQELAPSDNPHVLVDMLTSHSFTLSWKDYSTESQPGFIQGYHVYLKSKARQCHPRFQKAVLSDGSECCRYKIDNPEEKALIVDNLKPESFYEFFVTPFTSAGEGPNATFTKVTTPDEHSS

Approximately 110-130 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

≥ 95%, as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.