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OSMR beta Protein, Cynomolgus (HEK293, His)

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OSMR beta protein is a type I cytokine receptor in the type 2 subfamily and is critical in cell signaling and immune responses. OSMR beta serves as a receptor for oncostatin M, a cytokine that plays a role in inflammation, cell growth, and differentiation, and is critical for downstream signaling and regulation of cell function. OSMR beta Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived OSMR beta protein, expressed by HEK293 , with C-His labeled tag.

For research use only. We do not sell to patients.
  • Species: Cynomolgus
  • Source: HEK293
  • Storage:
    Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
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Biological Activity

Description

OSMR beta protein is a type I cytokine receptor in the type 2 subfamily and is critical in cell signaling and immune responses. OSMR beta serves as a receptor for oncostatin M, a cytokine that plays a role in inflammation, cell growth, and differentiation, and is critical for downstream signaling and regulation of cell function. OSMR beta Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived OSMR beta protein, expressed by HEK293 , with C-His labeled tag.

Background

The OSMR beta protein belongs to the type I cytokine receptor family, specifically the type 2 subfamily. This protein plays a significant role in cellular signaling and immune responses. It acts as a receptor for oncostatin M, a cytokine involved in various biological processes such as inflammation, cell growth, and differentiation. The OSMR beta protein is essential for the activation of downstream signaling pathways and the regulation of cellular functions. Understanding the function and regulation of OSMR beta protein can provide valuable insights into the development of therapeutic strategies for diseases involving dysregulation of cytokine signaling or immune responses.

Verified Bioactivity

Immobilized Cynomolgus OSMR, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Anti-OSMR Antibody, hFc Tag with the EC50 of 6.1-7.1ng/mL determined by ELISA.

Technical Parameters

  • Species Cynomolgus
  • Source HEK293
  • Tag C-8*His
  • Accession

    A0A2K5UFW5 (E28-S737)

  • Gene ID
    102135082
  • Molecular Construction
    • N-term
    • OSMR beta (E28-S737)
      Accession # A0A2K5UFW5
    • 8*His
    • C-term
  • Protein Length

    Extracellular Domain

  • Synonyms

    OSMR; IL-31 Receptor Subunit Beta; Oncostatin M Receptor; IL-31R Subunit Beta; OSMRB; IL-31R-Beta; Oncostatin-M-Specific Receptor Subunit Beta; IL-31RB; OSMRbeta; Oncostatin-M Specific Receptor Beta Subunit; Interleukin-31 Receptor Subunit Beta; PLCA1

  • AA Sequence

    ERLPLTPVSLKVSTNSIHQSLHLQWTVHNLPYHQELKMVFQIQISRIETSNVVWVGNYSTPVKWNQVLHWSWESELPLECATHFVRIKSVIDDASFPEPNFWSNWSSWEEVSVQDYLGRGTLFVFPKDKLVEEGSNVTICYVSRNIQNNVSCYLEGKQIHGEQLDPHVTAFNLNSVPFIRNRGTNIYCEASQGNVSKGIEGIVLFVSKVLEEPKDFSCESQDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQDSQEMYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSMRNNFTYLCQIELHGEGKMMQQYDVSINVNGEYFLSELEPATEYMARVRCADASHFWKWTEWSGQNFTTLEAAPSEAPDVWRSVNSEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSRSELRSIPAPANSTKLILDRCSYQICVTANNSVGASPASIIVISADPENKEVEEERIAGTEGGFSLSWKPQPGDVIGYVVDWCDHPQDVLQWKNVGPNTTSTVISTDAFRPGVRYDFRIYGLSTKRIACLLEKKTGYSQELAPSDNPHVLVDMLTSHSFTLSWKDYSTESQPGFIQGYHVYLKSKARQCHPRFQKAVLSDGSECCRYKIDNPEEKALIVDNLKPESFYEFFVTPFTSAGEGPNATFTKVTTPDEHSS

  • Predicted Molecular Mass

    82 kDa

  • Molecular Weight

    Approximately 105-130 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

  • Purity

    ≥ 95%, as determined by reducing SDS-PAGE.

Product Properties

Appearance

Lyophilized powder

Formulation

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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Dilution Calculator

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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