1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Neprilysin

Neprilysin

Neprilysin (NEP) is a type II membrane metalloendopeptidase composed of ∼750 residues with an active site containing a zinc-binding motif (HEXXH) at the extracellular carboxyl terminal domain. Neprilysin is capable of degrading the monomeric and the oligomeric forms of Aβ peptide. Neprilysin is the dominant Aβ peptide-degrading enzyme in the brain; Neprilysin becomes inactivated and down-regulated during both the early stages of Alzheimer’s disease (AD) and aging.

Neprilysin is a neutral endopeptidase and its inhibition increases bioavailability of natriuretic peptides, bradykinin, and substance P, resulting in natriuretic, vasodilatatory, and anti-proliferative effects.

Neprilysin Related Products (11):

Cat. No. Product Name Effect Purity
  • HY-18204A
    LCZ696 Inhibitor 99.99%
    LCZ696 (Sacubitril mixture with Valsartan) is the first angiotensin receptor-neprilysin inhibitor (ARNi) to be used clinically. LCZ696 inhibits the nuclear transfer of NF-κB, JNK/p38MAPK phosphorylation, mitigates inflammation and apoptosis in diabetic mice and H9C2 cardiomyocytes under high-glucose (HG) conditions. LCZ696 is a combination of valsartan and AHU377, at a ratio of 1:1, which is synthesized through a complex chemical reaction, and it attenuats cardiac remodeling and dysfunction after myocardial infarction (MI) by reducing cardiac fibrosis and hypertrophy.
  • HY-17620
    Sacubitrilat Inhibitor 99.85%
    Sacubitrilat is an active neprilysin (NEP) inhibitor.
  • HY-15407
    Sacubitril Inhibitor 99.71%
    Sacubitril (AHU-377) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril (AHU-377) is a component of the heart failure medicine LCZ696.
  • HY-N2021A
    Phosphoramidon Disodium Inhibitor >98.0%
    Phosphoramidon Disodium is a metalloprotease inhibitor. Phosphoramidon inhibits endothelin-converting enzyme (ECE), neutral endopeptidase (NEP), and angiotensin-converting enzyme (ACE) with IC50 values of 3.5, 0.034, and 78 μM, respectively.
  • HY-15407A
    Sacubitril hemicalcium salt Inhibitor 99.64%
    Sacubitril hemicalcium salt (AHU-377 hemicalcium salt) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril hemicalcium salt is a component of the heart failure medicine LCZ696.
  • HY-114412
    TD-0212 Inhibitor
    TD-0212 (compound 35) is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP.
  • HY-17399
    Racecadotril Inhibitor >98.0%
    Racecadotril (acetorphan), a potent enkephalinase inhibitor (IC50= 4.5 uM), protects endogenous enkephalins from degradation.
  • HY-19649
    Candoxatril Inhibitor
    Candoxatril is a neutral endopeptidase (NEP) inhibitor.
  • HY-U00171
    SQ28603 Inhibitor
    SQ28603 is a potent and selective inhibitor of neutral endopeptidase 3.4.24.11 (NEP), an enzyme that degrades atrial natriuretic peptide (ANP).
  • HY-U00294
    NEP-In-1 Inhibitor
    NEP-IN-1 is a neutral endopeptidase (NEP) inhibitor with IC50 of 2 nM for dNEP.
  • HY-U00336
    NEP-IN-2 Inhibitor
    NEP-IN-2 is an inhibitor of neutral endopeptidase, used in the research of proliferation in atherosclerosis, restenosis.
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