1. Metabolic Enzyme/Protease
  2. Neprilysin

Candoxatril (Synonyms: UK 79300)

Cat. No.: HY-19649
Handling Instructions

Candoxatril is a neutral endopeptidase (NEP) inhibitor.

For research use only. We do not sell to patients.

Candoxatril Chemical Structure

Candoxatril Chemical Structure

CAS No. : 123122-55-4

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  • Biological Activity

  • Protocol

  • Technical Information

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  • References

Description

Candoxatril is a neutral endopeptidase (NEP) inhibitor.

IC50 & Target

NEP[1].

In Vivo

While the NEP inhibitors have no significant effect on body weight, food and water intake, mean blood pressure or creatinine levels, they do increase cGMP levels in the urine and affected hematopoiesis in an anti-inflammatory way. Moreover, a-SMA deposition in the kidney cortex is inversely correlated with cGMP elevation suggesting a NEP dependent antifibroti effect. High quality mRNA profiles are obtained with at least 8 independent samples per treatment group. The data confirms the cGMP dependent anti-fibrotic action of Sol-1 and further supports the potential therapeutic actions of this neutral endopeptidase inhibitor[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9393 mL 9.6967 mL 19.3934 mL
5 mM 0.3879 mL 1.9393 mL 3.8787 mL
10 mM 0.1939 mL 0.9697 mL 1.9393 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[2]

Mice[2]
Mice (n=10 per group) subjected to UUO are treated for 1 week with either Solvent, SOL-1 (NEP-/ECE-inhibitor two doses), Candoxatril (reference NEP inhibitor) or losartan (angiotensin AT1-receptor antagonist) and compared to sham operated animals[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

515.64

Formula

C₂₉H₄₁NO₇

CAS No.

123122-55-4

SMILES

O=C(C1(CCCC1)C[[email protected]@H](COCCOC)C(OC2=CC=C(CCC3)C3=C2)=O)N[[email protected]]4CC[[email protected]@H](C(O)=O)CC4

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Candoxatril
Cat. No.:
HY-19649
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Candoxatril

Cat. No.: HY-19649