1. Metabolic Enzyme/Protease
  2. Neprilysin
  3. Candoxatril

Candoxatril is a neutral endopeptidase (NEP) inhibitor.

For research use only. We do not sell to patients.

Candoxatril Chemical Structure

Candoxatril Chemical Structure

CAS No. : 123122-55-4

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Description

Candoxatril is a neutral endopeptidase (NEP) inhibitor.

IC50 & Target

NEP[1].

In Vivo

While the NEP inhibitors have no significant effect on body weight, food and water intake, mean blood pressure or creatinine levels, they do increase cGMP levels in the urine and affected hematopoiesis in an anti-inflammatory way. Moreover, a-SMA deposition in the kidney cortex is inversely correlated with cGMP elevation suggesting a NEP dependent antifibroti effect. High quality mRNA profiles are obtained with at least 8 independent samples per treatment group. The data confirms the cGMP dependent anti-fibrotic action of Sol-1 and further supports the potential therapeutic actions of this neutral endopeptidase inhibitor[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

515.64

Formula

C29H41NO7

CAS No.
SMILES

O=C(C1(CCCC1)C[C@@H](COCCOC)C(OC2=CC=C(CCC3)C3=C2)=O)N[C@H]4CC[C@@H](C(O)=O)CC4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
Animal Administration
[2]

Mice[2]
Mice (n=10 per group) subjected to UUO are treated for 1 week with either Solvent, SOL-1 (NEP-/ECE-inhibitor two doses), Candoxatril (reference NEP inhibitor) or losartan (angiotensin AT1-receptor antagonist) and compared to sham operated animals[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Candoxatril Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Candoxatril
Cat. No.:
HY-19649
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