2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. TGF-beta Superfamily Neurotrophic Factors
  5. GDNF family

GDNF family

Related Products

XLSX 5.34 KB

The glial cell line-derived (GDNF) family ligands (GFLs) of neurotrophic factors include 4 closely related proteins: GDNF, neurturin (NRTN), artemin (ARTN), and persephin (PSPN). Growth/differentiation factor 15 (GDF15), a protein of the TGF-β superfamily protein and is a distantly related member of GFL. Notably, all GDNF family proteins are members of the TGF-β superfamily. GFLs signaling is mainly mediated by transmembrane receptor tyrosine kinase RET to form triplet complexes. GFLs form homologous dimers that bind to corresponding co-receptors GFRα1-4 and GFRAL respectively[1].

Subscribe Now to the List of Recombinant Proteins

 
Cat. No. Product Name / Synonyms Species Source
  • HY-P77945
    GDF-15 Protein, Mouse (HEK293, Fc)

    GDF-15; MIC-1; NAG-1; PDF; PLAB; PTGFB; GDF15; MIC1; RG-1; Placental TGF-beta; PTGF-beta; PTGFBPTGF-beta

    		Mouse HEK293
    Growth differentiation factor 15 (GDF-15) is a polypeptide hormone belonging to the transforming growth factor β (TGF-β) superfamily. GDF-15 is also known as non-steroidal anti-inflammatory drug activating Gene-1 (NAG-1), placental transforming growth factor-β (PTGFB), prostate-derived factor (PDF), and placental bone morphogenetic protein (PLAB). GDF-15 binds to glial cell-derived neurotrophic factor (GDNF) family receptor alpha-like protein (GFRAL) and is involved in aging, cancer, and metabolic processes. GFRAL-GDF15 does not affect SMAD activity and activates intracellular signals including RET, AKT, ERK1/2, and phospholipase C (PLCγ). GDF-15 Protein, Mouse (HEK293, Fc) has 115 amino acids expressed by HEK293 cells with N-terminal hFc tag.
  • HY-P73074
    GDNF Protein, Human (HEK293)

    Glial cell line-derived neurotrophic factor; ATF; HFB1-GDNF; HGDNF; HSCR3

    		Human HEK293
    Glial-cell-line-derived neurotrophic factor (GDNF), a neurotrophic factor belongs to the GDNF family ligands (GFLs)., promotes survival of dopamine neurons. GDNF demonstrates a variety of neuroprotective roles for mammalian neurons. GDNF Protein, Human (HEK293) is produced in HEK293 cells, and consists of 103 amino acids (R83-I185).
  • HY-P73075
    GDNF Protein, Rat (sf9, His)

    Glial cell line-derived neurotrophic factor; ATF; HFB1-GDNF; HGDNF; HSCR3

    		Rat Sf9 insect cells
    Glial-cell-line-derived neurotrophic factor (GDNF), a neurotrophic factor belongs to the GDNF family ligands (GFLs)., promotes survival of dopamine neurons. GDNF demonstrates a variety of neuroprotective roles for mammalian neurons. GDNF Protein, Rat (sf9, His) is produced in Sf9 insect cells with a N-Terminal His-tag. It consists of 134 amino acids (S78-I211).
  • HY-P77946
    GDF-15 Protein, Mouse (Biotinylated, HEK293, Fc)

    GDF-15; MIC-1; NAG-1; PDF; PLAB; PTGFB; GDF15; MIC1; RG-1; Placental TGF-beta; PTGF-beta; PTGFBPTGF-beta

    		Mouse HEK293
    Growth differentiation factor 15 (GDF-15) is a polypeptide hormone belonging to the transforming growth factor β (TGF-β) superfamily. GDF-15 is also known as non-steroidal anti-inflammatory drug activating Gene-1 (NAG-1), placental transforming growth factor-β (PTGFB), prostate-derived factor (PDF), and placental bone morphogenetic protein (PLAB). GDF-15 binds to glial cell-derived neurotrophic factor (GDNF) family receptor alpha-like protein (GFRAL) and is involved in aging, cancer, and metabolic processes. GFRAL-GDF15 does not affect SMAD activity and activates intracellular signals including RET, AKT, ERK1/2, and phospholipase C (PLCγ). GDF-15 Protein, Mouse (Biotinylated, HEK293, Fc) has 115 amino acids expressed by HEK293 cells with N-terminal hFc tag.
  • HY-P78134
    GDF-15 Protein, Human (Biotinylated, HEK293, Fc)

    GDF-15; MIC-1; NAG-1; PDF; PLAB; PTGFB; GDF15; MIC1; RG-1; Placental TGF-beta; PTGF-beta; PTGFBPTGF-beta; Placental TGF-β; PTGF-β; PTGFBPTGF-β

    		Human HEK293
    Growth differentiation factor 15 (GDF-15) is a polypeptide hormone belonging to the transforming growth factor β (TGF-β) superfamily. GDF-15 is also known as non-steroidal anti-inflammatory drug activating Gene-1 (NAG-1), placental transforming growth factor-β (PTGFB), prostate-derived factor (PDF), and placental bone morphogenetic protein (PLAB). GDF-15 binds to glial cell-derived neurotrophic factor (GDNF) family receptor alpha-like protein (GFRAL) and is involved in aging, cancer, and metabolic processes. GFRAL-GDF15 does not affect SMAD activity and activates intracellular signals including RET, AKT, ERK1/2, and phospholipase C (PLCγ). GDF-15 Protein, Human (Biotinylated, HEK293, Fc) has 112 amino acids expressed by HEK293 cells with N-terminal hFc tag.
  • HY-P700084AF
    Animal-Free GDNF Protein, Human (His)

    Glial cell line-derived neurotrophic factor; ATF; HFB1-GDNF; HGDNF; HSCR3

    		Human E. coli
    Glial-cell-line-derived neurotrophic factor (GDNF), a neurotrophic factor belongs to the GDNF family ligands (GFLs)., promotes survival of dopamine neurons. GDNF demonstrates a variety of neuroprotective roles for mammalian neurons. Animal-Free GDNF Protein, Human (His), a recombinant animal-free protein, is produced in E.coil with a C-Terminal His-tag. It consists of 134 amino acids (S78-I211).
  • HY-P7359
    GDNF Protein, Mouse (CHO)

    rMuGDNF; GDNF; ATF

    		Mouse CHO
    Glial-cell-line-derived neurotrophic factor (GDNF), a neurotrophic factor belongs to the GDNF family ligands (GFLs)., promotes survival of dopamine neurons. GDNF demonstrates a variety of neuroprotective roles for mammalian neurons. GDNF Protein, Mouse (CHO) is produced in CHO cells, and consists of 134 amino acids (S78-I211).
  • HY-P75171
    GDF-15 Protein, Human (HEK293, Fc)

    Growth/differentiation factor 15; MIC-1; NAG-1; NRG-1; PTGFB

    		Human HEK293
    Growth differentiation factor 15 (GDF-15) is a polypeptide hormone belonging to the transforming growth factor β (TGF-β) superfamily. GDF-15 is also known as non-steroidal anti-inflammatory drug activating Gene-1 (NAG-1), placental transforming growth factor-β (PTGFB), prostate-derived factor (PDF), and placental bone morphogenetic protein (PLAB). GDF-15 binds to glial cell-derived neurotrophic factor (GDNF) family receptor alpha-like protein (GFRAL) and is involved in aging, cancer, and metabolic processes. GFRAL-GDF15 does not affect SMAD activity and activates intracellular signals including RET, AKT, ERK1/2, and phospholipase C (PLCγ). GDF-15 Protein, Human (HEK293, Fc) has 112 amino acids expressed by HEK293 cells with N-terminal hFc tag.
  • HY-P76948
    GFRA1/GDNFR-alpha-1 Protein, Rat (HEK293, Fc)

    GFRα1; GDNF Family Receptor Alpha-1; GFR-Alpha-1; RET Ligand 1; GDNFRA; RETL1; TRNR1

    		Rat HEK293
  • HY-P76949
    GFRA1/GDNFR-alpha-1 Protein, Rat (HEK293, His)

    GFRα1; GDNF Family Receptor Alpha-1; GFR-Alpha-1; RET Ligand 1; GDNFRA; RETL1; TRNR1

    		Rat HEK293
  • HY-P78135
    GFRAL Protein, Human (Biotinylated, HEK293, His-Avi)

    GFR alpha-like; GFRAL; GRAL; C6orf144

    		Human HEK293
  • HY-P700179AF
    Animal-Free GDNF Protein, Mouse (His)

    rMuGDNF; GDNF; ATF

    		Mouse E. coli
    Glial-cell-line-derived neurotrophic factor (GDNF), a neurotrophic factor belongs to the GDNF family ligands (GFLs)., promotes survival of dopamine neurons. GDNF demonstrates a variety of neuroprotective roles for mammalian neurons. Animal-Free GDNF Protein, Mouse (His), a recombinant animal-free protein, is produced in E.coil with a C-Terminal His-tag. It consists of 134 amino acids (S78-I211).
  • HY-P7182
    GDNF Protein, Human

    rHuGDNF; ATF

    		Human E. coli
    Glial-cell-line-derived neurotrophic factor (GDNF), a neurotrophic factor belongs to the GDNF family ligands (GFLs)., promotes survival of dopamine neurons. GDNF demonstrates a variety of neuroprotective roles for mammalian neurons. GDNF Protein, Human is produced in E.coil, and consists of 134 amino acids (S78-I211).
  • HY-P75170
    GDF-15 Protein, Human (P.pastoris, His)

    Growth/differentiation factor 15; MIC-1; NAG-1; NRG-1; PTGFB

    		Human P. pastoris
    Growth differentiation factor 15 (GDF-15) is a polypeptide hormone belonging to the transforming growth factor β (TGF-β) superfamily. GDF-15 is also known as non-steroidal anti-inflammatory drug activating Gene-1 (NAG-1), placental transforming growth factor-β (PTGFB), prostate-derived factor (PDF), and placental bone morphogenetic protein (PLAB). GDF-15 binds to glial cell-derived neurotrophic factor (GDNF) family receptor alpha-like protein (GFRAL) and is involved in aging, cancer, and metabolic processes. GFRAL-GDF15 does not affect SMAD activity and activates intracellular signals including RET, AKT, ERK1/2, and phospholipase C (PLCγ). GDF-15 Protein, Human (P.pastoris, His) has 112 amino acids expressed by P.pastoris yeast cells with N-terminal His tag.
  • HY-P700224AF
    Animal-Free Neurturin Protein, Mouse (His)

    NTN; NRTN

    		Mouse E. coli
  • HY-P700726
    GDF-15 Protein, Canine (His)

    GDF-15; MIC-1; NAG-1; PDF; PLAB; PTGFB; GDF15; MIC1; RG-1; Placental TGF-beta; PTGF-beta; PTGFBPTGF-beta; Placental TGF-β; PTGF-β; PTGFBPTGF-β

    		Canine E. coli
  • HY-P700727
    GDF-15 Protein, Rat (His)

    GDF-15; MIC-1; NAG-1; PDF; PLAB; PTGFB; GDF15; MIC1; RG-1; Placental TGF-beta; PTGF-beta; PTGFBPTGF-beta; Placental TGF-β; PTGF-β; PTGFBPTGF-β

    		Rat E. coli
  • HY-P70384
    GFRA1/GDNFR-alpha-1 Protein, Human (410a.a, HEK293, His)

    rHuGDNF family receptor alpha-1/GFRA1, His; GFRα1; GDNF Family Receptor Alpha-1; GDNF Receptor Alpha-1; GDNFR-Alpha-1; GFR-Alpha-1; RET Ligand 1; TGF-Beta-Related Neurotrophic Factor Receptor 1; GFRA1; GDNFRA; RETL1; TRNR1

    		Human HEK293
  • HY-P75584
    Artemin Protein, Mouse (HEK293, Fc)

    Artemin; ARTN; Enovin; EVN; EVNneurotrophic factor; NBN; Neublastin

    		Mouse HEK293
  • HY-P7607
    Artemin Protein, Human

    rHuArtemin; Artemin, ARTN, Enovin

    		Human E. coli
    Artemin Protein, Human, a member of the glial cell line-derived neurotrophic factor (GDNF) family, is the ligand for the former orphan receptor GFRalpha3-RET. Artemin is a survival factor for sensory and sympathetic neurons in culture, and also influences these neurons in vivo.
Cat. No. Product Name Effect Purity