GFRAL
GFRAL (GFR-alpha-like, also known as IGFBP7R1) is the dedicated receptor for GDF-15 and, unlike GFRα-1 to -3, binds no GDNF-family ligands. This GPI-anchored protein is expressed almost exclusively in the area postrema and nucleus of the solitary tract of the hindbrain, outside the blood-brain barrier. GDF-15 binding to GFRAL recruits RET and triggers signaling that suppresses appetite and induces nausea, aversion and weight loss; the pathway mediates cancer- and chronic-disease-associated cachexia as well as effects of stress and metformin. Anti-GFRAL antibodies are being developed for cachexia while GFRAL agonism is explored for obesity. Recombinant GFRAL enables these investigations.
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GFRAL Protéines Recombinantes (11)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
