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GFRAL Protein, Human (HEK293, His-Avi)

Cat. No.: HY-P78449
Handling Instructions

GFRAL Protein, a brainstem-restricted receptor for GDF15, regulates food intake, energy expenditure, and body weight in response to metabolic and toxin-induced stresses. Binding to its ligand, GDF15, GFRAL interacts with RET, activating MAPK- and AKT-signaling pathways. Through its extracellular domain, the receptor forms complexes with GDF15 and RET, mediating cellular signaling when RET is engaged post GDF15 binding. This interaction sequence underscores GFRAL's role in modulating physiological responses to metabolic challenges. GFRAL Protein, Human (HEK293, His-Avi) is the recombinant human-derived GFRAL protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of GFRAL Protein, Human (HEK293, His-Avi) is 333 a.a., with molecular weight of 48-62 kDa.

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Description

GFRAL Protein, a brainstem-restricted receptor for GDF15, regulates food intake, energy expenditure, and body weight in response to metabolic and toxin-induced stresses. Binding to its ligand, GDF15, GFRAL interacts with RET, activating MAPK- and AKT-signaling pathways. Through its extracellular domain, the receptor forms complexes with GDF15 and RET, mediating cellular signaling when RET is engaged post GDF15 binding. This interaction sequence underscores GFRAL's role in modulating physiological responses to metabolic challenges. GFRAL Protein, Human (HEK293, His-Avi) is the recombinant human-derived GFRAL protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of GFRAL Protein, Human (HEK293, His-Avi) is 333 a.a., with molecular weight of 48-62 kDa.

Background

GFRAL Protein, a brainstem-restricted receptor for GDF15, plays a crucial role in regulating food intake, energy expenditure, and body weight in response to metabolic and toxin-induced stresses. Upon binding to its ligand, GDF15, GFRAL interacts with RET and activates cellular signaling through the MAPK- and AKT-signaling pathways. The receptor, through its extracellular domain, forms complexes with both GDF15 and RET, mediating cellular signaling specifically when RET is engaged after GDF15 binding. This intricate interaction highlights the sequential steps involving GFRAL, GDF15, and RET in the modulation of physiological responses to metabolic challenges.

Species

Human

Source

HEK293

Tag

C-Avi;C-His

Accession

Q6UXV0 (S19-E351)

Gene ID
Molecular Construction
N-term
GFRAL (S19-E351)
Accession # Q6UXV0
His-Avi
C-term
Synonyms
GFR alpha-like; GFRAL; GRAL; C6orf144
Molecular Weight

48-62 kDa

Purity

Greater than 95% as determined by Tris-Bis PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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GFRAL Protein, Human (HEK293, His-Avi)
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HY-P78449
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