GFRAL - GDNF family receptor alpha like Gene

Also Known as GRAL; UNQ9356; C6orf144; bA360D14.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 389400

About GFRAL

Cytogenetic location: 6p12.1 Genomic coordinates (GRCh38): 6:55,327,469-55,402,493 (from NCBI)

This gene has 1 transcript (splice variant), 174 orthologues and 4 paralogues. Low expression observed in reference dataset.

Summary

Enables glial cell-derived neurotrophic factor receptor activity and receptor tyrosine kinase binding activity. Involved in glial cell-derived neurotrophic factor receptor signaling pathway; positive regulation of MAPK cascade; and positive regulation of protein kinase B signaling. Located in external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

GFRAL Products (1)

mRNA Protein Name
NM_207410.2 NP_997293.2 GDNF family receptor alpha-like precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glial cell-derived neurotrophic factor receptor activity IDA
IDA: Inferred from direct assay
28846097 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28846097 GOA
enables receptor tyrosine kinase binding IPI
IPI: Inferred from physical interaction
28846097 GOA
Biological Process GO Annotation Evidence References Source
involved in GDF15-GFRAL signaling pathway IDA
IDA: Inferred from direct assay
28953886 GOA
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
28846099 GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
28846097 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
28953886 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GFRAL Protein Structure

GDNF

GDNF: GDNF/GAS1 domain (131 - 210)

GDNF

GDNF: GDNF/GAS1 domain (220 - 316)

  • 0
  • 100
  • 200
  • 300
  • 394 a.a.
Protein Preferred Names Protein Names

GDNF family receptor alpha-like

  • IVFI9356

Recombinant GFRAL Proteins

Cat. No. Product Name Accession Purity
HY-P71580 GFRAL Protein, Human (His-SUMO) Q6UXV0 (S19-E351) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P78135 GFRAL Protein, Human (Biotinylated, HEK293, His-Avi) Q6UXV0 (S19-E351) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78449 GFRAL Protein, Human (HEK293, His-Avi) Q6UXV0 (S19-E351) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99241 Ponsegromab Inhibitor 99.60% Phase 3
HY-P990635 NGM-120 Inhibitor 99.28% Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W587486 N-Acetyltaurine 99.91% Unkown
HY-W587486R N-Acetyltaurine (Standard) Activator 99.33% Unkown
HY-RS05390 GFRAL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17340 Gfral Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23795 Gfral Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W587486A N-Acetyltaurine hemimagnesium / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992393 JMT203 / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GFRAL VGNC VGNC:62532
Rattus norvegicus GFRAL RGD RGD:1565220
Macaca mulatta GFRAL VGNC VGNC:104386
Canis familiaris GFRAL VGNC VGNC:41192
Bos taurus GFRAL VGNC VGNC:53972
Mus musculus GFRAL MGD MGI:3607786
Others GFRAL NCBI