2. Metabolic Enzyme/Protease Anti-infection
  3. Endogenous Metabolite Bacterial
  4. N-Acetyltaurine hemimagnesium

N-Acetyltaurine hemimagnesium is an orally active endogenous sulfonate that is synthesized from taurine and acetate in the renal cortex. N-Acetyltaurine hemimagnesium supports bacterial growth as a sole fixed nitrogen or carbon source. N-Acetyltaurine hemimagnesium buffers acetyl moieties of mitochondrial acetyl‑CoA in skeletal muscle. N-Acetyltaurine hemimagnesium reduces food intake and body weight in obese and lean wild‑type mice in a GFRAL‑dependent manner. N-Acetyltaurine hemimagnesium can be used for the research of diet‑induced obesity, hyperacetatemia and diabetes.

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N-Acetyltaurine hemimagnesium

N-Acetyltaurine hemimagnesium Chemical Structure

CAS No. : 75350-40-2

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N-Acetyltaurine hemimagnesium Related Antibodies

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Description

N-Acetyltaurine hemimagnesium is an orally active endogenous sulfonate that is synthesized from taurine and acetate in the renal cortex. N-Acetyltaurine hemimagnesium supports bacterial growth as a sole fixed nitrogen or carbon source. N-Acetyltaurine hemimagnesium buffers acetyl moieties of mitochondrial acetyl‑CoA in skeletal muscle. N-Acetyltaurine hemimagnesium reduces food intake and body weight in obese and lean wild‑type mice in a GFRAL‑dependent manner. N-Acetyltaurine hemimagnesium can be used for the research of diet‑induced obesity, hyperacetatemia and diabetes[1][2][3][4][5].

In Vitro

N‑acetyltaurine (100 μM; 1 h) hemimagnesium is hydrolyzed into taurine and acetate by recombinant mouse PTER protein, and shows high hydrolytic activity in HEK293T cells overexpressing PTER but no activity in PTER‑KO HEK293T cells[2].
N‑acetyltaurine hemimagnesium is synthesized from taurine and acetate in mouse renal cortex homogenate and in primary human skeletal muscle cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-Acetyltaurine hemimagnesium Related Antibodies
In Vivo

N-acetyltaurine (1-50 mg/kg; i.p.; daily; 7 days) hemimagnesium administered intraperitoneally to DIO male mice reduces body weight and food intake in a dose-dependent manner[2].
N-acetyltaurine (15-50 mg/kg; i.p.; daily; 7 days) hemimagnesium reduces body weight and food intake in healthy chow-fed male mice[2].
N-acetyltaurine (15 mg/kg; i.p.; daily; 7 days) hemimagnesium reduces body weight and food intake in DIO male mice[2].
N-acetyltaurine (15 mg/kg; i.p.; daily; 7 days) hemimagnesium reduces body weight and food intake in DIO male Mc4r KO mice, indicating the effects of N-acetyltaurine hemimagnesium do not require functional MC4R receptors[2].
N-acetyltaurine (50-500 mg/kg; p.o.; daily; 7 days) hemimagnesium administered orally to DIO male mice reduces body weight and food intake in a dose-dependent manner, with significant effects observed at doses of 150 mg/kg and 500 mg/kg daily for 7 days, and achieves measurable plasma levels following oral gavage[2].
N-Acetyltaurine hemimagnesium levels were increased in response to Triacetin (HY-B0896)-induced hyperacetatemia[5].
N-Acetyltaurine hemimagnesium levels were significantly increased in response to endogenous hyperacetatemia from Streptozotocin (HY-13753)-induced diabetes[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (male, 26-28 weeks old, diet-induced obese)[2]
Dosage: 1 mg/kg; 5 mg/kg; 15 mg/kg; 50 mg/kg
Administration: i.p.; daily; 7 days
Result: Reduced body weight change and food intake in a dose-dependent manner at 15 mg/kg and 50 mg/kg compared with vehicle.
Animal Model: C57BL/6J (male, 19-21 weeks old, diet-induced obese)[2]
Dosage: 15 mg/kg
Administration: i.p.; daily; 7 days
Result: Reduced body weight change and food intake significantly compared with vehicle.
Animal Model: C57BL/6J (male, 16 weeks old, diet-induced obese)[2]
Dosage: 15 mg/kg
Administration: i.p.; daily; 7 days
Result: Reduced body weight gain and food intake significantly.
Animal Model: C57BL/6J (male, 3 months old, diet-induced obese)[2]
Dosage: 50 mg/kg; 150 mg/kg; 500 mg/kg
Administration: p.o.; daily; 7 days
Result: Increased plasma N-acetyltaurine levels dose-dependently.
Reduced body weight gain and food intake significantly at 150 mg/kg and 500 mg/kg.
Animal Model: Mc4r KO (C57BL/6J background, male, 3-4 months old, diet-induced obese)[2]
Dosage: 15 mg/kg
Administration: i.p.; daily; 7 days
Result: Reduced body weight change and food intake significantly compared with vehicle, similar to effects observed in wild-type DIO mice.
Molecular Weight

179.34

Formula

C4H9NO4S·1/2Mg
CAS No.
SMILES

O=C(C)NCCS(=O)(O)=O.[Mg].[1/2]
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Purity & Documentation
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N-Acetyltaurine hemimagnesium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Acetyltaurine hemimagnesium75350-40-2Endogenous MetaboliteBacterialGDF15orb spiderswild-type micesulfoacetaldehyde acetyltransferaseN-acetyltaurine amidaseDelftia acidovorans NATacetateGFRAL receptorstaurine dehydrogenasetaurineInhibitorinhibitorinhibit

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