N-Acetyltaurine hemimagnesium
N-Acetyltaurine hemimagnesium is an orally active endogenous sulfonate that is synthesized from taurine and acetate in the renal cortex. N-Acetyltaurine hemimagnesium supports bacterial growth as a sole fixed nitrogen or carbon source. N-Acetyltaurine hemimagnesium buffers acetyl moieties of mitochondrial acetyl‑CoA in skeletal muscle. N-Acetyltaurine hemimagnesium reduces food intake and body weight in obese and lean wild‑type mice in a GFRAL‑dependent manner. N-Acetyltaurine hemimagnesium can be used for the research of diet‑induced obesity, hyperacetatemia and diabetes.
For research use only. We do not sell to patients.
- CAS No.: 75350-40-2
- Formula: C4H9NO4S·1/2Mg
- Molecular Weight:179.34
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Endogenous Metabolite Isoforms
More
Biological Activity
|
GDF15 |
N‑acetyltaurine (100 μM; 1 h) hemimagnesium is hydrolyzed into taurine and acetate by recombinant mouse PTER protein, and shows high hydrolytic activity in HEK293T cells overexpressing PTER but no activity in PTER‑KO HEK293T cells[2].
N‑acetyltaurine hemimagnesium is synthesized from taurine and acetate in mouse renal cortex homogenate and in primary human skeletal muscle cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
N-acetyltaurine (15-50 mg/kg; i.p.; daily; 7 days) hemimagnesium reduces body weight and food intake in healthy chow-fed male mice[2].
N-acetyltaurine (15 mg/kg; i.p.; daily; 7 days) hemimagnesium reduces body weight and food intake in DIO male mice[2].
N-acetyltaurine (15 mg/kg; i.p.; daily; 7 days) hemimagnesium reduces body weight and food intake in DIO male Mc4r KO mice, indicating the effects of N-acetyltaurine hemimagnesium do not require functional MC4R receptors[2].
N-acetyltaurine (50-500 mg/kg; p.o.; daily; 7 days) hemimagnesium administered orally to DIO male mice reduces body weight and food intake in a dose-dependent manner, with significant effects observed at doses of 150 mg/kg and 500 mg/kg daily for 7 days, and achieves measurable plasma levels following oral gavage[2].
N-Acetyltaurine hemimagnesium levels were increased in response to Triacetin (HY-B0896)-induced hyperacetatemia[5].
N-Acetyltaurine hemimagnesium levels were significantly increased in response to endogenous hyperacetatemia from Streptozotocin (HY-13753)-induced diabetes[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57BL/6J (male, 26-28 weeks old, diet-induced obese)[2]
-
Dosage:1 mg/kg; 5 mg/kg; 15 mg/kg; 50 mg/kg
-
Administration:i.p.; daily; 7 days
-
Result:Reduced body weight change and food intake in a dose-dependent manner at 15 mg/kg and 50 mg/kg compared with vehicle.
-
Animal Model:C57BL/6J (male, 19-21 weeks old, diet-induced obese)[2]
-
Dosage:15 mg/kg
-
Administration:i.p.; daily; 7 days
-
Result:Reduced body weight change and food intake significantly compared with vehicle.
-
Animal Model:C57BL/6J (male, 16 weeks old, diet-induced obese)[2]
-
Dosage:15 mg/kg
-
Administration:i.p.; daily; 7 days
-
Result:Reduced body weight gain and food intake significantly.
-
Animal Model:C57BL/6J (male, 3 months old, diet-induced obese)[2]
-
Dosage:50 mg/kg; 150 mg/kg; 500 mg/kg
-
Administration:p.o.; daily; 7 days
-
Result:Increased plasma N-acetyltaurine levels dose-dependently.
Reduced body weight gain and food intake significantly at 150 mg/kg and 500 mg/kg.
-
Animal Model:Mc4r KO (C57BL/6J background, male, 3-4 months old, diet-induced obese)[2]
-
Dosage:15 mg/kg
-
Administration:i.p.; daily; 7 days
-
Result:Reduced body weight change and food intake significantly compared with vehicle, similar to effects observed in wild-type DIO mice.
Chemical Information
-
CAS No. 75350-40-2
-
Molecular Weight 179.34
-
Formula C4H9NO4S·1/2Mg
-
SMILES
O=C(C)NCCS(=O)(O)=O.[Mg].[1/2]
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Mayer J, et al. N-acetyltaurine dissimilated via taurine by Delftia acidovorans NAT. Arch Microbiol. 2006;186(1):61-67. [Content Brief]
[2]. Wei W, et al. PTER is a N-acetyltaurine hydrolase that regulates feeding and obesity. Nature. 2024;633(8028):182-188. [Content Brief]
[3]. Miyazaki T, et al. N-acetyltaurine and Acetylcarnitine Production for the Mitochondrial Acetyl-CoA Regulation in Skeletal Muscles during Endurance Exercises. Metabolites. 2021;11(8):522. Published 2021 Aug 6. [Content Brief]
[4]. Luginbühl M, et al. N-Acetyltaurine as a novel urinary ethanol marker in a drinking study. Anal Bioanal Chem. 2016;408(26):7529-7536. [Content Brief]
[5]. Mao Q, et al. Characterization of Urinary N-Acetyltaurine as a Biomarker of Hyperacetatemia in Mice. Metabolites. 2024;14(6):322. Published 2024 Jun 7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
N-Acetyltaurine hemimagnesium Related Classifications
HY-W587486A Related Classifications
Powered by Bioz