75350-40-2
Chemical Structure
N-Acetyltaurine hemimagnesium
- CAS No.: 75350-40-2
- Formula:C4H9NO4S·1/2Mg
- Molecular Weight:179.34
SMILES: O=C(C)NCCS(=O)(O)=O.[Mg].[1/2]
Biological Activity: N-Acetyltaurine hemimagnesium is an orally active endogenous sulfonate that is synthesized from taurine and acetate in the renal cortex. N-Acetyltaurine hemimagnesium supports bacterial growth as a sole fixed nitrogen or carbon source. N-Acetyltaurine hemimagnesium buffers acetyl moieties of mitochondrial acetyl‑CoA in skeletal muscle. N-Acetyltaurine hemimagnesium reduces food intake and body weight in obese and lean wild‑type mice in a GFRAL‑dependent manner. N-Acetyltaurine hemimagnesium can be used for the research of diet‑induced obesity, hyperacetatemia and diabetes[1][2][3][4][5].
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N-Acetyltaurine hemimagnesium | N-Acetyltaurine hemimagnesium is an orally active endogenous sulfonate that is synthesized from taurine and acetate in the renal cortex. N-Acetyltaurine hemimagnesium supports bacterial growth as a sole fixed nitrogen or carbon source. N-Acetyltaurine hemimagnesium buffers acetyl moieties of mitochondrial acetyl‑CoA in skeletal muscle. N-Acetyltaurine hemimagnesium reduces food intake and body weight in obese and lean wild‑type mice in a GFRAL‑dependent manner. N-Acetyltaurine hemimagnesium can be used for the research of diet‑induced obesity, hyperacetatemia and diabetes. | |||||||||||||||||||||
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- [1]. Mayer J, et al. N-acetyltaurine dissimilated via taurine by Delftia acidovorans NAT. Arch Microbiol. 2006;186(1):61-67. [Content Brief]
- [2]. Wei W, et al. PTER is a N-acetyltaurine hydrolase that regulates feeding and obesity. Nature. 2024;633(8028):182-188. [Content Brief]
- [3]. Miyazaki T, et al. N-acetyltaurine and Acetylcarnitine Production for the Mitochondrial Acetyl-CoA Regulation in Skeletal Muscles during Endurance Exercises. Metabolites. 2021;11(8):522. Published 2021 Aug 6. [Content Brief]
- [4]. Luginbühl M, et al. N-Acetyltaurine as a novel urinary ethanol marker in a drinking study. Anal Bioanal Chem. 2016;408(26):7529-7536. [Content Brief]
- [5]. Mao Q, et al. Characterization of Urinary N-Acetyltaurine as a Biomarker of Hyperacetatemia in Mice. Metabolites. 2024;14(6):322. Published 2024 Jun 7. [Content Brief]
Keywords
