1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Thrombin


Thrombin is a serine protease that in humans is encoded by the F2 gene. Thrombin is an intriguing coagulation protease demonstrating an array of effects on endothelial cells, vascular smooth muscle cells (VSMC), monocytes, and platelets, all of which are involved in the pathophysiology of atherosclerosis. There is mounting evidence that thrombin acts as a powerful modulator of many processes like regulation of vascular tone, permeability, migration and proliferation of VSMC, recruitment of monocytes into the atherosclerotic lesions, induction of diverse pro-inflammatory markers, and all of these are related to the progression of cardiovascular disease. Recent studies in transgenic mice models indicate that the deletion of the natural thrombin inhibitor heparin cofactor II promotes an accelerated atherogenic state. The combined evidence points to thrombin as a pivotal contributor to vascular pathophysiology. Considering the clinical development of selective anticoagulants including direct thrombin inhibitors.

Thrombin Related Products (24):

Cat. No. Product Name Effect Purity
  • HY-12821
    AEBSF hydrochloride Inhibitor 99.76%
    AEBSF hydrochloride is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, plasmin, thrombin, and trypsin.
  • HY-114164
    Thrombin is a trypsin-like allosteric serine protease. Thrombin enables site-specific cleavage of fusion proteins with an accessible Thrombin recognition sequence and can be used to digest GST-tagged proteins.
  • HY-10163
    Dabigatran Inhibitor >98.0%
    Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM).
  • HY-10274
    Dabigatran etexilate Inhibitor 99.79%
    Dabigatran etexilate(BIBR-1048) is the orally active prodrug of dabigatran; Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM.
  • HY-15664
    Bivalirudin TFA Inhibitor 99.76%
    Bivalirudin TFA is a synthetic 20 residue peptide which reversibly inhibits thrombin.
  • HY-10217
    Thrombin Inhibitor 2 Inhibitor
    Thrombin Inhibitor 2 is a small molecule direct thrombin inhibitor, extracted from US8541580B2. Thrombin Inhibitor 2 has antithrombotic activity.
  • HY-10277
    Odiparcil Inhibitor >99.0%
    Odiparcil (SB-424323) is an orally active beta-d-thioxyloside analog with antithrombotic activity associated with a reduced risk of adverse bleeding events. Odiparcil (SB-424323) is indirect thrombin inhibitor that exerts its anticoagulant effect through activation of antithrombin II (heparin cofactor II) .
  • HY-10787
    Ximelagatran Inhibitor >98.0%
    Ximelagatran (H 376/95) is an orally active thrombin inhibitor that selectively and competitively inhibits both free and clot-bound thrombin. Ximelagatran is an anticoagulant agent with a rapid onset of anticoagulant effect, predictable, dose-dependent pharmcokinetics and pharmacodynamics.
  • HY-10274A
    Dabigatran etexilate mesylate Inhibitor 99.60%
    Dabigatran etexilate mesylate (BIBR 1048MS) is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM.
  • HY-B0375A
    Argatroban monohydrate Inhibitor 99.95%
    Argatroban (monohydrate) (MD-805 (monohydrate)) is a direct, selective thrombin inhibitor.
  • HY-17378
    Dabigatran ethyl ester Inhibitor 99.26%
    Dabigatran ethyl ester is an emerging oral anticoagulant which is a direct inhibitor of thrombin activity.
  • HY-77521
    Dabigatran ethyl ester hydrochloride Inhibitor 99.88%
    Dabigatran ethyl ester hydrochloride is a potent inhibitor of ribosyldihydronicotinamide dehydrogenase (NQO2) with an IC50 value of 0.8 μM and a thrombin inhibitor.
  • HY-B0209
    Metolazone Inhibitor 99.32%
    Metolazone(Zaroxolyn) is primarily used to treat congestive heart failure and high blood pressure.
  • HY-P1000
    Sfllrnpndkyepf Agonist 98.22%
    Sfllrnpndkyepf is a synthetic thrombin receptor agonist peptide.
  • HY-101054
    NQ301 98.89%
    NQ301 is an antithrombotic agent; inhibits collagen-challenged rabbit platelet aggregation with an IC50 of 10 mg/mL.
  • HY-129056
    Melagatran Inhibitor
    Melagatran is a direct and orally active inhibitor of thrombin, without interacting with any other enzymes in the coagulation cascade or fibrinolytic enzymes aside from thrombin. Melagatran does not require endogenous co-factors for its antithrombin effect and may help to alleviate some of the damaging effects of endotoxemia. Melagatran has the potential to provide a rational approach in the prevention of arterial occlusion.
  • HY-100245
    OM-189 Inhibitor
    OM-189 is a selective synthetic thrombin inhibitor.
  • HY-B0375
    Argatroban Inhibitor
    Argatroban (MD-805) is a direct, selective thrombin inhibitor.
  • HY-10163AS
    Dabigatran D4 hydrochloride Inhibitor
    Dabigatran D4 hydrochloride is deuterium labeled Dabigatran, which is a reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM.
  • HY-15759A
    Napsagatran hydrate Inhibitor
    Napsagatran hydrate is a novel and specific thrombin inhibitor.
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