2. Cytoskeleton Autophagy Metabolic Enzyme/Protease Anti-infection
  3. Exosomes Thrombin Autophagy Endogenous Metabolite Bacterial
  4. Heparin

Heparin is a highly sulfated glycosaminoglycan,that is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule. Heparin significantly inhibits exosome-cell interactions.

For research use only. We do not sell to patients.

CAS No. : 9005-49-6

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Customer Review

Based on 8 publication(s) in Google Scholar

Other Forms of Heparin:

Heparin Related Antibodies

Top Publications Citing Use of Products

    Heparin purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Sep 22:87:103877.  [Abstract]

    ELISA analysis of TNF-α in culture supernatants from BMDMs stimulated with LPS (1 μg/mL) in the presence or absence of octaparin (5 μg/mL), heparin (5 μg/mL), enoxaparin (5 μg/mL) and fondaparinux (5 μg/mL) for 24 h.

    Heparin purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Sep 22:87:103877.  [Abstract]

    ELISA analysis of IL-6 in culture supernatants from BMDMs stimulated with LPS (1 μg/mL) in the presence or absence of octaparin (5 μg/mL), heparin (5 μg/mL), enoxaparin (5 μg/mL) and fondaparinux (5 μg/mL) for 24 h.

    Heparin purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Sep 22:87:103877.  [Abstract]

    Relative fluorescence intensity of TMRM in BMDMs treated with LPS (1 μg/mL) for 24 h in the presence or absence of octaparin (5 μg/mL), heparin (5 μg/mL), enoxaparin (5 μg/mL) and fondaparinux (5 μg/mL).

    Heparin purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Sep 22:87:103877.  [Abstract]

    Relative fluorescence intensity of MitoSOX in BMDMs treated with LPS (1 μg/mL) for 24 h in the presence or absence of octaparin (5 μg/mL), heparin (5 μg/mL), enoxaparin (5 μg/mL) and fondaparinux (5 μg/mL).

    Heparin purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Sep 22:87:103877.  [Abstract]

    Relative fluorescence intensity of H2DCFDA in BMDMs treated with LPS (1 μg/mL) for 24 h in the presence or absence of octaparin (5 μg/mL), heparin (5 μg/mL), enoxaparin (5 μg/mL) and fondaparinux (5 μg/mL).

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    Human Endogenous Metabolite Microbial Metabolite

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    Description

    Heparin is a highly sulfated glycosaminoglycan,that is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule. Heparin significantly inhibits exosome-cell interactions.

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    Heparin (6 days) reduces the cytopathogenicity of HIV for MT-4 cells, with an IC50 of 7.5 μg/mL[2].
    Heparin (0.5 U/mL, 48 h) inhibits HGF-induced trophoblast invasion in the SGHPL-4 cell line[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Heparin Related Antibodies
    Clinical Trial
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O[C@H]1[C@H](O[C@H]2[C@H](OS(O)(=O)=O)[C@@H](O)[C@H](OC)[C@H](C(O)=O)O2)[C@@H](COS(O)(=O)=O)O[C@H](OC)[C@@H]1NS(O)(=O)=O.[n]
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : ≥ 100 mg/mL

    *"≥" means soluble, but saturation unknown.

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    Heparin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Heparin9005-49-6ExosomesThrombinAutophagyEndogenous MetaboliteBacterialInhibitorinhibitorinhibit

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