Thrombin

By Targets:	Protease Activated Receptor (PAR) (30) Thrombin (62) 5-HT Receptor (2) Amino Acid Derivatives (2) Apoptosis (5) Autophagy (4) Bacterial (3) Calcium Channel (1) CETP (1) Deubiquitinase (1) Elastase (2) Factor Xa (20) Fluorescent Dye (8) Glycoprotein VI (2) Influenza Virus (1) Interleukin Related (1) Isotope-Labeled Compounds (3) JNK (1) NF-κB (1) NO Synthase (2) P2Y Receptor (2) Phosphodiesterase (PDE) (1) PKC (2) Potassium Channel (1) Proteasome (2) SARS-CoV (1) Ser/Thr Protease (9) Small Interfering RNA (siRNA) (2) Src (1) Syk (1) Transferrin Receptor (1) Vasopressin Receptor (2)
By Research Areas:	Cancer (15) Cardiovascular Disease (98) Infection (4) Inflammation/Immunology (28) Metabolic Disease (9) Neurological Disease (3)

Targets Recommended: Thrombin Protease Activated Receptor (PAR)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10217

Thrombin Inhibitor 2	Thrombin	Cardiovascular Disease
Thrombin Inhibitor 2 is a small molecule direct *thrombin* inhibitor, extracted from US8541580B2. Thrombin Inhibitor 2 has antithrombotic activity .

HY-148037

Thrombin inhibitor 5	Proteasome	Cardiovascular Disease
Thrombin inhibitor 5 (compound 385) is a *thrombin* inhibitor, with IC₅₀s ranging from 0.1 μM to 1 μM. Thrombin inhibitor 5 can be used for research of venous thromboembolism .

HY-162109

Thrombin inhibitor 11

Thrombin Cardiovascular Disease

Thrombin inhibitor 11 is a thrombin inhibitor, with human and rat K_i values of 65 nM and 10.3 nM, respectively .
HY-151983

Thrombin inhibitor 6

Thrombin Cardiovascular Disease

Thrombin inhibitor 6 is a potent thrombin inhibitor (IC₅₀: 1 nM). Thrombin inhibitor 6 has the function as an anticoagulant .

Thrombin inhibitor 11	Thrombin	Cardiovascular Disease
Thrombin inhibitor 11 is a thrombin inhibitor, with human and rat K_i values of 65 nM and 10.3 nM, respectively .

Thrombin inhibitor 6	Thrombin	Cardiovascular Disease
Thrombin inhibitor 6 is a potent thrombin inhibitor (IC₅₀: 1 nM). Thrombin inhibitor 6 has the function as an anticoagulant .

HY-P5889

Thrombin receptor peptide ligand	Thrombin	Cardiovascular Disease
Thrombin receptor peptide ligand is a *thrombin* receptor antagonist peptide that can be used as an antithrombotic agent .

HY-U00370

Thrombin inhibitor 1

Thrombin Cardiovascular Disease

Thrombin inhibitor 1 is a potent thrombin inhibitor (K_i=0.66 nM, 2xaPTT=0.43 μM).

Thrombin inhibitor 1	Thrombin	Cardiovascular Disease
Thrombin inhibitor 1 is a potent *thrombin* inhibitor (K_i=0.66 nM, 2xaPTT=0.43 μM).

HY-114164

Thrombin (MW 37kDa) 4 Publications Verification	Thrombin	Neurological Disease
Thrombin (MW 37kDa) is a Na ⁺-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Thrombin recognition sequence and can be used to digest GST-tagged proteins.

HY-P0078

TRAP-6 4 Publications Verification PAR-1 agonist peptide; Thrombin Receptor Activator Peptide 6	Protease Activated Receptor (PAR)	Inflammation/Immunology
TRAP-6 (PAR-1 agonist peptide), a peptide fragment, is a selective protease activating receptor 1 (PAR1) agonist. TRAP-6 activates human platelets via the thrombin receptor. TRAP-6 shows no activity at PAR4 .

HY-152150

Thrombin inhibitor 7	Others	Metabolic Disease
Thrombin inhibitor 7 is a potent FXIIa inhibitor with IC₅₀ values of 28 nM, >132 µM for FXIIa and FXIa, respectively. Thrombin inhibitor 7 shows low cytotoxicity .

HY-P1536

Thrombin Receptor Activator for Peptide 5 (TRAP-5)	Protease Activated Receptor (PAR)	Cardiovascular Disease
Thrombin Receptor Activator for Peptide 5 (TRAP-5) is also called Coagulation Factor II Receptor (1-5) or Proteinase Activated Receptor 1 (1-5), used in the research of coronary heart disease (CHD).

HY-114164A

Human α-Thrombin EC 3.4.21.5; Human Alpha Thrombin	Thrombin	Cardiovascular Disease
Human α-thrombin is a multifunctional serine protease that plays a pivotal role in the coagulation pathway. Human α-thrombin cleaves fibrinogen and converts it into fibrin. Human α-thrombin can stimulate platelet activation and stabilize fibrin polymers .

HY-12605

SAR107375	Thrombin	Metabolic Disease
SAR107375 is a potent and orally active dual thrombin and factor Xa inhibitor, with K_i values of 1 nM and 8 nM for factor Xa and thrombin, respectively .

HY-N10762

15,16-Dihydrotanshindiol C

Thrombin Cardiovascular Disease

15,16-Dihydrotanshindiol C, a diterpenoid, is a potent thrombin inhibitor .
HY-N3701

Decursidate

Others Others

Decursidate is an active compound. Decursidate can prolong thrombin time .
HY-P10094

β-Ala-Gly-Arg-pNA

Fluorescent Dye Others

β-Ala-Gly-Arg-pNA is a chromogenic substrate of thrombin with pNA a strong absorbance at 405 nm .
HY-120563

LY135305

Thrombin Cardiovascular Disease

LY 135305 is a thrombin activation inhibitor. LY 135305 inhibits spontaneous metastasis and increases animal survival .

15,16-Dihydrotanshindiol C	Thrombin	Cardiovascular Disease
15,16-Dihydrotanshindiol C, a diterpenoid, is a potent *thrombin* inhibitor .

Decursidate	Others	Others
Decursidate is an active compound. Decursidate can prolong thrombin time .

β-Ala-Gly-Arg-pNA	Fluorescent Dye	Others
β-Ala-Gly-Arg-pNA is a chromogenic substrate of *thrombin* with pNA a strong absorbance at 405 nm .

LY135305	Thrombin	Cardiovascular Disease
LY 135305 is a thrombin activation inhibitor. LY 135305 inhibits spontaneous metastasis and increases animal survival .

HY-162374

ANO61	Calcium Channel	Cardiovascular Disease
ANO61 is a dibenzyl formamide derivative, which exhibits an antiplatelet efficacy through modulation of thrombin-induced Ca ²⁺ response with an IC₅₀ of 47.7 μM .

HY-108555

FR-171113	Protease Activated Receptor (PAR)	Cardiovascular Disease
FR171113 is a specific and non-peptide thrombin receptor antagonist. FR171113 exhibits the antithrombotic effects of a PAR1 antagonist. FR171113 inhibits thrombin-induced platelet aggregation with an IC₅₀ of 0.29 μM. .

HY-123550

Rosenonolactone

Thrombin CETP Inflammation/Immunology

Rosenonolactone shows inhibitory activity against prolyl endopeptidase and thrombin and cholesterol ester transfer protein .

Rosenonolactone	Thrombin CETP	Inflammation/Immunology
Rosenonolactone shows inhibitory activity against prolyl endopeptidase and *thrombin* and cholesterol ester transfer protein .

HY-14936

Sofigatran MCC-977	Thrombin	Cardiovascular Disease
Sofigatran (MCC-977) is an orally active factor IIa (thrombin) inhibitor, acts as an anticoagulant. Sofigatran is used for the research of cardiovascular disease .

HY-N8278

Dermatan sulphate sodium	Thrombin	Cardiovascular Disease Inflammation/Immunology
Dermatan sulphate sodium is a glycosaminoglycan and thrombin inactivator with antithrombotic activity. Dermatan sulphate sodium selectively catalyzes the inactivation of thrombin by heparin cofactor II and does not interact with antithrombin III. Dermatan sulphate sodium is highly bioavailable and also reduces Bleomycin (HY-108345)-induced pulmonary fibrosis damage .

HY-112995

Lepirudin	Thrombin	Inflammation/Immunology
Lepirudin is a potent irreversible *thrombin* inhibitor. Lepirudin also is a recombinant hirudin. Lepirudin has anticoagulation in heparin-induced thrombocytopenia (HIT) .

HY-123275A

H-D-Phe-Pip-Arg-pNA hydrochloride S-2238 hydrochloride	Fluorescent Dye	Others
H-D-Phe-Pip-Arg-pNA (S-2238) hydrochloride, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA hydrochloride is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA hydrochloride is sensitive, accurate, and easy to perform .

HY-123275

H-D-Phe-Pip-Arg-pNA S-2238	Fluorescent Dye	Others
H-D-Phe-Pip-Arg-pNA (S-2238), a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA is sensitive, accurate, and easy to perform .

HY-123275C

H-D-Phe-Pip-Arg-pNA dihydrochloride S-2238 dihydrochloride	Fluorescent Dye	Others
H-D-Phe-Pip-Arg-pNA (S-2238) dihydrochloride, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA dihydrochloride is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA dihydrochloride is sensitive, accurate, and easy to perform .

HY-123275B

H-D-Phe-Pip-Arg-pNA acetate S-2238 acetate	Fluorescent Dye	Others
H-D-Phe-Pip-Arg-pNA (S-2238) acetate, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA acetate is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA acetate is sensitive, accurate, and easy to perform .

HY-P0316

TP508	Thrombin NO Synthase	Cardiovascular Disease
TP508 is a 23-amino acid nonproteolytic *thrombin* peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 activates endothelial NO synthase (eNOS) and stimulates production of NO in human endothelial cells. TP508 activates endothelial cells and stem cells to revascularize and regenerate tissues .

HY-N10582

Aeruginosin 98-B	Protease Activated Receptor (PAR) Thrombin	Infection Metabolic Disease Inflammation/Immunology Cancer
Aeruginosin 98-B is a protease inhibitor. Aeruginosin 98-B inhibits trypsin, plasmin and thrombin with IC₅₀ values of 0.6, 7.0 and 10.0 μg/mL, respectively .

HY-P0316A

TP508 TFA	Thrombin NO Synthase	Cardiovascular Disease
TP508 TFA is a 23-amino acid nonproteolytic *thrombin* peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 TFA activates endothelial NO synthase (eNOS) and stimulates production of NO in human endothelial cells. TP508 TFA activates endothelial cells and stem cells to revascularize and regenerate tissues .

HY-P2518

Protease-Activated Receptor-1, PAR-1 Agonist	Protease Activated Receptor (PAR)	Inflammation/Immunology
Protease-Activated Receptor-1, PAR-1 Agonist is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor .

HY-151146

(1R,3S)-THCCA-Asn	Thrombin	Cardiovascular Disease
(1R,3S)-THCCA-Asn (4j) is a selective *thrombin* inhibitor with the IC₅₀ value in the range of 0.07 to 0.14 μM. ((1R,3S)-THCCA-Asn has antithrombotic activity .

HY-17567C

Heparin sodium salt (MW 15kDa) 1 Publications Verification Sodium heparin (MW 15kDa); Sodium heparinate (MW 15kDa)	Thrombin Factor Xa Autophagy	Cardiovascular Disease
Heparin sodium salt (MW 15kDa) (Sodium heparin (MW 15kDa)) is a polymer of Heparin with the molecular weight of 15kDa. Heparin sodium salt is an anticoagulant which binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin factor IIa and factor Xa .

HY-18660

Ciraparantag PER977	Factor Xa	Cardiovascular Disease
Ciraparantag is a *thrombin* and factor Xa inhibitor. Ciraparantag is a broad-spectrum reversal agent for anticoagulants, including low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants. It is reported to antagonize the effects of all coagulants except VKAs and agratroban .

HY-114080

Patamostat E-3123	Ser/Thr Protease	Inflammation/Immunology
Patamostat (E-3123) is a potent protease inhibitor. Patamostat potently inhibits trypsin, plasmin and thrombin with IC₅₀s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat may possess suppressing effects on pathogenesis and development of acute pancreatitis .

HY-114080A

Patamostat mesylate E-3123 mesylate	Ser/Thr Protease	Inflammation/Immunology
Patamostat (E-3123) mesylate is a potent protease inhibitor. Patamostat mesylate potently inhibits trypsin, plasmin and thrombin with IC₅₀s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat mesylate may possess suppressing effects on pathogenesis and development of acute pancreatitis .

HY-P99415

Abelacimab MAA868	Factor Xa	Cardiovascular Disease
Abelacimab (MAA868) is a fully human IgG1 monoclonal antibody that binds with high affinity to the catalytic structural domain of FXI and locks it in the zymogen conformation, thereby preventing its activation by FXIIa or thrombin. Abelacimab can be used in thromboembolic disease studies .

HY-150790

BMS-986141	Protease Activated Receptor (PAR)	Cardiovascular Disease
BMS-98614 is an orally active, selective thrombin receptor protease-activated receptor-4 (PAR-4) antagonist with an IC₅₀ value of 0.4 nM. BMS-98614 has excellent antithrombotic effect .

HY-18740A

Trequinsin hydrochloride HL 725	Phosphodiesterase (PDE)	Metabolic Disease
Trequinsin hydrochloride (HL 725) is an extremely potent inhibitor of platelet CAMP phosphodiesterase (PDE), with an IC₅₀ of 0.25 nM. Trequinsin hydrochloride (HL 725) is an extremely potent inhibitor of the aggregation of human platelets induced in vitro by ADP, collagen, thrombin and epinephrine .

HY-122052

UK‑396082	Others	Metabolic Disease
UK‑396082 is a potent thrombin activated fibrinolytic inhibitor (TAFI) inhibitor. UK‑396082 increases plasmin activity and induces a parallel decrease in ECM levels. UK‑396082 can be used in research of chronic kidney disease (CKD) .

HY-18200

Atopaxar E5555; ER-172594-00	Protease Activated Receptor (PAR)	Cardiovascular Disease
Atopaxar (E5555) is a potent, orally active, selective and reversible thrombin receptor protease-activated receptor-1 (PAR-1) antagonist. Atopaxar, an antiplatelet agent, interferes with platelet signaling. Atopaxar can be used for the research of atherothrombotic disease .

HY-14994

SCH79797 dihydrochloride 1 Publications Verification	Protease Activated Receptor (PAR) Apoptosis	Cardiovascular Disease
SCH79797 dihydrochloride is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797 dihydrochloride inhibits binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC₅₀ of 70 nM and a K_i of 35 nM. SCH79797 dihydrochloride inhibits thrombin-induced platelet aggregation with an IC₅₀ of 3 μM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 dihydrochloride also potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes .

HY-14993

SCH79797 1 Publications Verification	Protease Activated Receptor (PAR) Apoptosis	Cardiovascular Disease
SCH79797 is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797 inhibits binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC₅₀ of 70 nM and a K_i of 35 nM. SCH79797 inhibits thrombin-induced platelet aggregation with an IC₅₀ of 3 μM. SCH79797 has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 also potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes .

HY-18200B

Atopaxar hydrobromide E5555 hydrobromide; ER 172594-06	Protease Activated Receptor (PAR)	Cardiovascular Disease
Atopaxar (E5555) hydrobromide is a potent, orally active, selective and reversible thrombin receptor protease-activated receptor-1 (PAR-1) antagonist. Atopaxar hydrobromide, an antiplatelet agent, interferes with platelet signaling. Atopaxar hydrobromide can be used for the research of atherothrombotic disease .

HY-78263

MNS NSC 170724; 5-(2-Nitrovinyl)benzodioxole	Src Syk	Cancer
MNS (NSC 170724), the beta-nitrostyrene derivative, is a potent tyrosine kinase inhibitor and a broad-spectrum antiplatelet agent. MNS completely inhibits U46619, ADP-, arachidonic acid-, collagen-, and thrombin-induced platelet aggregation with IC₅₀ values of 2.1, 4.1, 5.8, 7.0, and 12.7 μM, respectively. MNS inhibits Src, Syk, and FAK with IC₅₀ of 27.3, 2.8, and 97.6 μM, respectively .

HY-115911

GPVI antagonist 2	Glycoprotein VI	Cardiovascular Disease
GPVI antagonist 2 (Compound 1) is a potential antagonist of Glycoprotein VI (GPVI). IC₅₀ values of GPVI antagonist 2 are, respectively, 0.35 μM for collagen, 0.80 μM for CRP, 195.2 μM for convulxin and 81.38 μM for thrombin. Glycoprotein VI (GPVI) is a platelet major collagen receptor and a target for potent and safe antithrombotic research. GPVI antagonist 2 is a promising antiplatelet agent .

HY-115912

GPVI antagonist 3	Glycoprotein VI	Cardiovascular Disease
GPVI antagonist 3 (Compound 2) is a potential antagonist of Glycoprotein VI (GPVI). IC₅₀ values of GPVI antagonist 3 are, respectively, 1.01 μM for collagen, 1.92 μM for CRP, 7.24 μM for convulxin and 51.74 μM for thrombin. Glycoprotein VI (GPVI) is a platelet major collagen receptor and a target for potent and safe antithrombotic research. GPVI antagonist 3 is a promising antiplatelet agent .

HY-19101

ONO-3307	Ser/Thr Protease	Cardiovascular Disease
ONO-3307 is a protease inhibitor that competitively inhibits a variety of proteases including trypsin, thrombin, plasma kallikrein, plasmin, pancreatic kallikrein, and chymotrypsin. ONO-3307 alleviates endotoxin-induced experimental disseminated intravascular coagulation (DIC) in rats. ONO-3307 can be used in the study of thrombosis and protease-mediated diseases .

HY-107613

R 59-022 1 Publications Verification DKGI-I; Diacylglycerol kinase inhibitor I	PKC 5-HT Receptor	Inflammation/Immunology
R 59-022 (DKGI-I) is a DGK inhibitor (IC₅₀: 2.8 µM). R 59-022 inhibits the phosphorylation of OAG to OAPA. R 59-022 is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils .

HY-107613A

R 59-022 hydrochloride 1 Publications Verification DKGI-I hydrochloride; Diacylglycerol kinase inhibitor I hydrochloride	PKC 5-HT Receptor	Infection Inflammation/Immunology Cancer
R 59-022 (DKGI-I) hydrochloride is a DGK inhibitor (IC₅₀: 2.8 µM). R 59-022 hydrochloride inhibits the phosphorylation of OAG to OAPA. R 59-022 hydrochloride is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 hydrochloride potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils .

HY-111056

UK122	Ser/Thr Protease	Cancer
UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC₅₀ of 0.2 μM. UK122 shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC₅₀>100 μM). UK122, 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion .

Cat. No.	Product Name

HY-L136

Coagulation and Anti-coagulation Compound Library

965 compounds

Coagulation, also known as clotting, is the process in which blood changes from a liquid to a solid gel to form a blood clot. Thrombin, which is accurately and evenly generated in the injured part of blood vessels, is a key effector enzyme of the blood coagulation system and participates in many important biological processes, such as platelet activation, fibrinogen conversion to fibrin network, coagulation feedback amplification, etc. At the same time, to avoid the accidental formation of thrombus in the body, there is also an anticoagulant mechanism that inhibits blood coagulation.

Normal coagulation mechanism represents a balance between the pro-coagulant pathway in the injured site and anti-coagulant pathway beyond it. The blood coagulation system may be out of balance during the perioperative period or critical illness, which may lead to thrombosis or excessive bleeding. Therefore, the physiological study of coagulation balance is an important basis for clinical diagnosis and treatment of the abnormal coagulation process.

MCE supplies a unique collection of 965 compounds targeting key proteins in coagulation and anti-coagulation system. MCE Coagulation and Anti-coagulation Compound Library is a useful tool for study the mechanism of coagulation and anticoagulation.

Cat. No.	Product Name	Type

HY-P0019A

Z-Gly-Gly-Arg-AMC acetate 5+ Cited Publications	Chromogenic Substrates
Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP).

HY-P0019

Z-Gly-Gly-Arg-AMC

Chromogenic Substrates

Z-Gly-Gly-Arg-AMC is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP).

Cat. No.	Product Name	Type

HY-125864

Fibrinogen (Bovine)

Native Proteins

Fibrinogen (Bovine) is a selective proteolytic molecule that can be activated by thrombin to assemble fibrin clots. Fibrinogen can regulate the activation of NF-KB in endothelial cells and upregulate the expression of inflammatory chemokines MCP-1 and MCP-1. Fibrinogen plays a key role in blood clotting, thrombosis, atherosclerosis and the pathological development of venous grafts, and can be used in the study of blood clotting and vascular diseases .

HY-107911

Protamine sulfate 1 Publications Verification	Native Proteins
Protamine sulfate, polycationic peptide and a antiheparin agent, could neutralize the anticoagulant action of heparin and enhances lipid-mediated gene transfer .

HY-W087937

Benzamidine hydrochloride hydrate 2 Publications Verification Benzenecarboximidamide hydrochloride hydrate	Biochemical Assay Reagents
Benzamidine (Benzenecarboximidamide) hydrochloride hydrate is a reversible competitive trypsin-like serine proteases inhibitor with K_is of 20, 21, 97, 110, 320 and 750 μM against Tryptase, Trypsin, uPA, Factor Xa, Thrombin and tPA, respectively .

HY-107966

Heparin calcium (MW 15000-19000) Nadroparin calcium (MW 15000-19000)	Cell Assay Reagents
Heparin calcium (MW 15000-19000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin .

HY-107966A

Heparin calcium (MW 3600-5000) Nadroparin calcium (MW 3600-5000)	Cell Assay Reagents
Heparin (Nadroparin) calcium (MW 3600-5000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin .

HY-P3267

Transferrins

Native Proteins

Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrin receptor. Transferrins can bind to and mediate the transport of iron .

Cat. No.	Product Name	Target	Research Area

HY-P0078

TRAP-6 4 Publications Verification PAR-1 agonist peptide; Thrombin Receptor Activator Peptide 6	Protease Activated Receptor (PAR)	Inflammation/Immunology
TRAP-6 (PAR-1 agonist peptide), a peptide fragment, is a selective protease activating receptor 1 (PAR1) agonist. TRAP-6 activates human platelets via the thrombin receptor. TRAP-6 shows no activity at PAR4 .

HY-P5889

Thrombin receptor peptide ligand	Thrombin	Cardiovascular Disease
Thrombin receptor peptide ligand is a *thrombin* receptor antagonist peptide that can be used as an antithrombotic agent .

HY-P1536

Thrombin Receptor Activator for Peptide 5 (TRAP-5)	Protease Activated Receptor (PAR)	Cardiovascular Disease
Thrombin Receptor Activator for Peptide 5 (TRAP-5) is also called Coagulation Factor II Receptor (1-5) or Proteinase Activated Receptor 1 (1-5), used in the research of coronary heart disease (CHD).

HY-P10094

β-Ala-Gly-Arg-pNA

Fluorescent Dye Others

β-Ala-Gly-Arg-pNA is a chromogenic substrate of thrombin with pNA a strong absorbance at 405 nm .

HY-P4302

Z-FK-ck Z-Phe-Lys-2,4,6-Trimethylbenzoyloxy-methylketone	Peptides	Cardiovascular Disease
Z-FK-ck (Z-Phe-Lys-2,4,6-Trimethylbenzoyloxy-methylketone) is a potent and selective gingipain-K-specific inhibitor. Z-FK-ck prolongs plasma thrombin time (TT) in a dose- and time-dependent manner .

HY-P1493A

Fibrinopeptide B, human TFA FPB,human TFA	Peptides	Inflammation/Immunology
Fibrinopeptide B, human TFA (FPB,human TFA), human is a 14-aa peptide, released from the amino-terminus of β-chains of fibrinogen by thrombin .

HY-112995

Lepirudin	Thrombin	Inflammation/Immunology
Lepirudin is a potent irreversible *thrombin* inhibitor. Lepirudin also is a recombinant hirudin. Lepirudin has anticoagulation in heparin-induced thrombocytopenia (HIT) .

HY-123275A

H-D-Phe-Pip-Arg-pNA hydrochloride S-2238 hydrochloride	Fluorescent Dye	Others
H-D-Phe-Pip-Arg-pNA (S-2238) hydrochloride, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA hydrochloride is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA hydrochloride is sensitive, accurate, and easy to perform .

HY-123275

H-D-Phe-Pip-Arg-pNA S-2238	Fluorescent Dye	Others
H-D-Phe-Pip-Arg-pNA (S-2238), a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA is sensitive, accurate, and easy to perform .

HY-123275C

H-D-Phe-Pip-Arg-pNA dihydrochloride S-2238 dihydrochloride	Fluorescent Dye	Others
H-D-Phe-Pip-Arg-pNA (S-2238) dihydrochloride, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA dihydrochloride is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA dihydrochloride is sensitive, accurate, and easy to perform .

HY-123275B

H-D-Phe-Pip-Arg-pNA acetate S-2238 acetate	Fluorescent Dye	Others
H-D-Phe-Pip-Arg-pNA (S-2238) acetate, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA acetate is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA acetate is sensitive, accurate, and easy to perform .

HY-P0316

TP508	Thrombin NO Synthase	Cardiovascular Disease
TP508 is a 23-amino acid nonproteolytic *thrombin* peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 activates endothelial NO synthase (eNOS) and stimulates production of NO in human endothelial cells. TP508 activates endothelial cells and stem cells to revascularize and regenerate tissues .

HY-P0316A

TP508 TFA	Thrombin NO Synthase	Cardiovascular Disease
TP508 TFA is a 23-amino acid nonproteolytic *thrombin* peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 TFA activates endothelial NO synthase (eNOS) and stimulates production of NO in human endothelial cells. TP508 TFA activates endothelial cells and stem cells to revascularize and regenerate tissues .

HY-P2518

Protease-Activated Receptor-1, PAR-1 Agonist	Protease Activated Receptor (PAR)	Inflammation/Immunology
Protease-Activated Receptor-1, PAR-1 Agonist is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor .

HY-W006069

H-Phe(3,5-DiF)-OH	Peptides	Others
H-Phe(3,5-DiF)-OH is a difluorophenylalanines in the L-configuration [L-(F2)Phe]. H-Phe(3,5-DiF)-OH can be incorporated into the thrombin receptor-tethered ligand peptide SFLLRNP to identify the phenyl hydrogens of the Phe-2 residue involved in the CH/π receptor interaction .

HY-P1263

tcY-NH2 (trans-Cinnamoyl)-YPGKF-NH2	Protease Activated Receptor (PAR)	Metabolic Disease Inflammation/Immunology
tcY-NH2 ((trans-Cinnamoyl)-YPGKF-NH2) is a potent selective PAR4 antagonist peptide. tcY-NH2 inhibits thrombin- and AY-NH₂-induced platelet aggregation and endostatin release, and can be used in the research of inflammation, immunology .

HY-W109513

Boc-Lys(Z)-OH (DCHA)	Amino Acid Derivatives	Inflammation/Immunology
Boc-Lys(Z)-OH (DCHA) is a involves in synthesis thymosin β4, βg and β6 fragments, and increases E-rosette forming capacity in Lupus Nephritis model. Boc-Lys(Z)-OH (DCHA) involves in synthesis Boc-Lyz-OCH3 and acts as a reagent of peptidyl thrombin inhibitors production .

HY-P0019

Z-Gly-Gly-Arg-AMC	Fluorescent Dye	Cardiovascular Disease
Z-Gly-Gly-Arg-AMC is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP).

HY-P0019A

Z-Gly-Gly-Arg-AMC acetate Maximum Cited Publications 8 Publications Verification	Fluorescent Dye	Others
Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP).

HY-P1263A

tcY-NH2 TFA 1 Publications Verification (trans-Cinnamoyl)-YPGKF-NH2 TFA	Protease Activated Receptor (PAR)	Metabolic Disease Inflammation/Immunology
tcY-NH2 ((trans-Cinnamoyl)-YPGKF-NH2) TFA is a potent selective PAR4 antagonist peptide. tcY-NH2 TFA inhibits thrombin- and AY-NH₂-induced platelet aggregation and endostatin release, and can be used in the research of inflammation, immunology .

HY-P4475

Sar-Pro-Arg-pNA

Thrombin Cardiovascular Disease

Sar-Pro-Arg-pNA is a chromogenic substrate of α-thrombin. Sar-Pro-Arg-pNA can be used to test α-thrombin activity .

HY-P5371

TFLLRNPNDK-NH2	Thrombin	Others
TFLLRNPNDK-NH2 is a biological active peptide. (This peptide is a thrombin receptor activating peptide. This PAR-1 agonist peptide reversibly binds to PAR-1 mimicking the 'tethered ligand' that thrombin makes available through proteolytic cleavage of substrate. It is also known to cause increase in liquid and protein permeability much like thrombin.)

HY-P1000

TRAP-14

SFLLRNPNDKYEPF
Thrombin Cardiovascular Disease

TRAP-14 (SFLLRNPNDKYEPF) is a synthetic thrombin receptor agonist peptide.
HY-15664

Bivalirudin TFA

5+ Cited Publications

Thrombin Cardiovascular Disease

Bivalirudin TFA is a synthetic 20 residue peptide which reversibly inhibits thrombin.

HY-P2490

Acetyl-Hirudin (54-65) (sulfated)	Peptides	Metabolic Disease
Acetyl-Hirudin (54-65) (sulfated) is a acetyl-fragment of Hirudin which binds directly to thrombin-rHCII(L444R) and disrupts interactions between the N-terminal acidic domain of rHCII and anion-binding exosite I of thrombin that serves to stabilize the complex .

HY-P2321

TRAP-6 amide

Protease Activated Receptor (PAR) Inflammation/Immunology

TRAP-6 amide is a PAR-1 thrombin receptor agonist peptide .
HY-P2321A

TRAP-6 amide TFA

Protease Activated Receptor (PAR) Inflammation/Immunology

TRAP-6 amide TFA is a PAR-1 thrombin receptor agonist peptide .
HY-P4259

Hirullin P18

Thrombin Cardiovascular Disease

Hirullin P18 is a potent thrombin inhibitor. Hirullin P18 has an anticoagulant effect .

HY-P4325

Hirudin (55-65) (sulfated)	Peptides	Others
Hirudin (55-65) (sulfated) is a fragment of Hirudin with anticoagulant effects. Hirudin is a thrombin inhibitor with blood anticoagulant property.

HY-P1636

Hirudin (54-65)	Peptides	Cardiovascular Disease
Hirudin (54-65) is a fragment of Hirudin with anticoagulant effects. Hirudin is a thrombin inhibitor with blood anticoagulant property .

HY-P5372

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2	Protease Activated Receptor (PAR)	Others
Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 is a biological active peptide. (Protease activated receptor 1 (PAR-1) belongs to a subfamily of G-protein coupled receptors and is known to mediate the cellular effects of thrombin. This peptide is a PAR-1 selective agonist displaying a high level of specificity to PAR-1 over PAR-2. The specificity of peptide was evaluated in cell-based calcium signaling assay using HEK293 cells. PAR-1 selective agonists can be used to study PAR-1 activation in vivo. In addition to its varied cellular effects of thrombin, PAR-1 has also been shown to coordinate with PAR-4 and regulate thrombin-induced hepatocellular carcinoma harboring thrombin formation within the tumor environment classified as 'coagulation type'.)

HY-P4593

Z-Gly-Pro-Arg-4MβNA	Thrombin	Others
Z-Gly-Pro-Arg-4MβNA is the cleavage of the substrate of thrombin to release free 4-methoxy-2-naphthylamine (4MβNA). Free 4MβNA can be captured by 5-nitrosalicylaldehyde to produce an insoluble yellow fluorescent and marks the site of thrombin activity .

HY-P1921

YRGDS Fibronectin Fragment	Peptides	Cardiovascular Disease
YRGDS Fibronectin Fragment is a fibronectin fragment, an adhesion peptide that displays strong binding affinity to thrombin-stimulated platelets .

HY-P4795

Acetyl-Hirudin (55-65) (sulfated)	Peptides	Others
Acetyl-Hirudin (55-65) (sulfated) is a Acetyl-fragment of Hirudin. Hirudin is a thrombin inhibitor with blood anticoagulant property .

HY-P1636A

Hirudin (54-65) (TFA)	Peptides	Cardiovascular Disease
Hirudin (54-65) TFA is a fragment of Hirudin with anticoagulant effects. Hirudin is a thrombin inhibitor with blood anticoagulant property .

HY-P1493

Fibrinopeptide B, human

FPB,human
Peptides Inflammation/Immunology

Fibrinopeptide B, human is a 14-aa peptide, released from the amino-terminus of β-chains of fibrinogen by thrombin.

HY-P1929

Bivalirudin 5+ Cited Publications	Thrombin	Cardiovascular Disease
Bivalirudin, a peptide anticoagulant, is a direct *thrombin* inhibitor for anticoagulation in the setting of invasive cardiology, particularly percutaneous coronary intervention .

HY-P1261

Parstatin(mouse)	Protease Activated Receptor (PAR)	Cardiovascular Disease Inflammation/Immunology
Parstatin(mouse), a cell-penetrating *PAR-1 thrombin* receptor** agonist peptide, is a potent inhibitor of angiogenesis .

HY-P1262

Parstatin(human)	Protease Activated Receptor (PAR)	Cardiovascular Disease Inflammation/Immunology
Parstatin(human), a cell-penetrating *PAR-1 thrombin* receptor** agonist peptide, is a potent inhibitor of angiogenesis .

HY-P1262A

Parstatin(human) TFA	Protease Activated Receptor (PAR)	Cardiovascular Disease Inflammation/Immunology
Parstatin(human) TFA, a cell-penetrating *PAR-1 thrombin* receptor** agonist peptide, is a potent inhibitor of angiogenesis .

HY-P1261A

Parstatin(mouse) TFA	Protease Activated Receptor (PAR)	Cardiovascular Disease Inflammation/Immunology
Parstatin(mouse) TFA, a cell-penetrating *PAR-1 thrombin* receptor** agonist peptide, is a potent inhibitor of angiogenesis .

HY-P1538

Fibrinopeptide A, human Human fibrinopeptide A	Peptides	Cardiovascular Disease
Fibrinopeptide A, human is a 16-residue short polypeptide cleaved from fibrinogen by thrombin. Fibrinopeptide A, human locates at the NH₂-termini of the Aα chain.

HY-P1538A

Fibrinopeptide A, human TFA Human fibrinopeptide A TFA	Peptides	Cardiovascular Disease
Fibrinopeptide A, human TFA is a 16-residue short polypeptide cleaved from fibrinogen by thrombin. Fibrinopeptide A, human locates at the NH₂-termini of the Aα chain .

HY-P4721

Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)	Thrombin	Cardiovascular Disease
Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is a hirugen-like peptide, and has high affnity for thrombin than Hirugen, with a K_D < 100 nM. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is an antithrombotic agent. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) inhibits the thrombin-induced fibrin clot formation with an IC50 value of 0.087 μM .

HY-P4349

Pyr-Arg-Thr-Lys-Arg-AMC	Peptides	Others
Pyr-Arg-Thr-Lys-Arg-AMC is a AMC peptide. AMC is a decapeptide that is specifically hydrolyzed by proteases such as trypsin and thrombin. The AMC peptide can be used to determine the activity of protease and the potency of enzyme inhibitors .

HY-105239

Selepressin FE 202158	Vasopressin Receptor	Cardiovascular Disease
Selepressin (FE 202158) is a selective vasopressin V_1A receptor agonist. Selepressin is a potent vasopressor. Selepressin can be used in the research of septic shock .

HY-105239A

Selepressin acetate FE 202158 acetate	Vasopressin Receptor	Cardiovascular Disease
Selepressin (FE 202158) acetate is a selective vasopressin V_1A receptor agonist. Selepressin acetate is a potent vasopressin. Selepressin acetate can be used in the study of septic shock.

HY-P4349A

Pyr-Arg-Thr-Lys-Arg-AMC TFA	Peptides	Others
Pyr-Arg-Thr-Lys-Arg-AMC TFA is a AMC peptide. AMC is a decapeptide that is specifically hydrolyzed by proteases such as trypsin and thrombin. The AMC peptide can be used to determine the activity of protease and the potency of enzyme inhibitors .

HY-P2813

Hirudin	Thrombin Apoptosis	Cardiovascular Disease Cancer
Hirudin is a *thrombin* inhibitor with blood anticoagulant property. Hirudin has potent anti-thrombotic, wound repair, anti-fibrosis, anti-tumor and anti-hyperuricemia effects. Hirudin also affects diabetic complications, cerebral hemorrhage, and others .

HY-P4987

TRAP-7	Protease Activated Receptor (PAR)	Cardiovascular Disease
TRAP-7 is a thrombin receptor (PAR) activating peptide. TRAP-7 stimulates total inositol phosphate (IP) accumulation and phosphorylation of a specific endogenous substrate for activated PKC. TRAP-7 can be used in cardiovascular disease research .

Cat. No.	Product Name	Target	Research Area

HY-P99415

Abelacimab MAA868	Factor Xa	Cardiovascular Disease
Abelacimab (MAA868) is a fully human IgG1 monoclonal antibody that binds with high affinity to the catalytic structural domain of FXI and locks it in the zymogen conformation, thereby preventing its activation by FXIIa or thrombin. Abelacimab can be used in thromboembolic disease studies .

HY-P99283

Concizumab NN 7415; mAb 2021; Anti-TFPI Recombinant Antibody	Inhibitory Antibodies	Others
Concizumab is an anti-TFPI monoclonal antibody (IgG4 type) that binds to the Kunitz-type protease inhibitor (KPI) 2 structural domain of TFPI, thereby blocking the interaction of this structural domain with the FXa active site. Concizumab can be used in the study of haemophilia .

HY-P99794

Osocimab BAY 1213790	Factor Xa	Cardiovascular Disease
Osocimab (BAY 1213790), an anti-FXIa antibody (K_i=2.4 nM; EC₅₀=0.2 nM). FXI inhibition may reduce the risk of thrombosis. Osocimab inhibits thrombin generation, and prolongs activated partial thromboplastin time. Osocimab exhibits anticoagulant effects .

HY-108739

Idarucizumab BI 655075	Inhibitory Antibodies	Cardiovascular Disease
Idarucizumab is a humanized monoclonal antibody fragment. Idarucizumab is first reversal agent for a direct oral anticoagulant (DOAC). Idarucizumab can specifically neutralize the effects of the oral direct thrombin inhibitor in order to restore hemostasis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2138

Buddlejasaponin IVb	Triterpenes Classification of Application Fields Terpenoids Labiatae Dipsacaceae Source classification Plants Helenium amarum (Raf.) H.Rock Dipsacus asper Inflammation/Immunology Disease Research Fields	Others
Buddlejasaponin IVb (Compound 2), a triterpene saponin isolated from Clinopodium chinense (Benth.) O. Kuntze, Compound 2 has hemostasis efficacy, shortens thrombin time (TT) by 20.6 % .

HY-N10762

15,16-Dihydrotanshindiol C	Structural Classification Terpenoids Labiatae Source classification Samanea saman (Jacq.) Merr. Diterpenoids Plants	Thrombin
15,16-Dihydrotanshindiol C, a diterpenoid, is a potent *thrombin* inhibitor .

HY-N3701

Decursidate	Structural Classification Source classification Phenols Polyphenols Plants Umbelliferae Echinacea angustifolia DC.	Others
Decursidate is an active compound. Decursidate can prolong thrombin time .

HY-123550

Rosenonolactone	Structural Classification Microorganisms Terpenoids Source classification Diterpenoids	Thrombin CETP
Rosenonolactone shows inhibitory activity against prolyl endopeptidase and *thrombin* and cholesterol ester transfer protein .

HY-N10582

Aeruginosin 98-B	Infection Structural Classification Natural Products other families Classification of Application Fields Marine algae Blue-green algae Marine natural products Metabolic Disease Plants Disease Research Fields Cancer	Protease Activated Receptor (PAR) Thrombin
Aeruginosin 98-B is a protease inhibitor. Aeruginosin 98-B inhibits trypsin, plasmin and thrombin with IC₅₀ values of 0.6, 7.0 and 10.0 μg/mL, respectively .

HY-N3919

γ-Methoxyisoeugenol	Structural Classification Monophenols Source classification Phenols Plants Umbelliferae Echinacea angustifolia DC.	Others
γ-Methoxyisoeugenol (Compound 5) is an anticoagulant agent that remarkably prolongs the thrombin time with a good dose-effect relationship at concentrations from 6.25 to 100 mM, but shows no significant differences in prothrombin time .

HY-N3670

Cycloolivil Isoolivil	Cardiovascular Disease Monophenols Classification of Application Fields Canarium album (Lour.) Rauesch. Source classification Lignans Phenols Phenylpropanoids Plants Burseraceae Disease Research Fields	Others
Cycloolivil (Isoolivil) is a natural polyphenolic compound with a significant radical scavenging activity. Antioxidant and Antiaggregant effects .

HY-N10271

SCH 38519	Infection Quinones Monophenols Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Disease Research Fields	Bacterial
SCH 38519 is a platelet aggregation inhibitor. SCH 38519 inhibits thrombin-induced aggregation of human platelets with an IC₅₀ of 68 μg/mL. SCH 38519 is also active against Gram-positive and Gram-negative bacteria .

Species:	Human (5) Mouse (1) Rat (1)
Tag:	His (7) Trx (1)
Source:	HEK293 (4) E. coli Cell-free (1) Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P7735

	Carboxypeptidase B2/CPB2 Protein, Human (HEK293, His) rHuCarboxypeptidase B2, His; Carboxypeptidase B2; Carboxypeptidase U; Plasma Carboxypeptidase B; Thrombin-Activable Fibrinolysis Inhibitor; CPB2	Human	HEK293
	Carboxypeptidase B2 Protein, Human (HEK293, His) is an approximately 47.0 kDa human carboxypeptidase B2 with a His-flag. Carboxypeptidase B2 is a enzyme belonging to the peptidase M14 family and hydrolyze C-terminal peptide bonds.

HY-P73612

	Thrombin Receptor/PAR1 Protein, Human (HEK293, His) Cf2r; CF2RHTR; F2R; HTR; PAR1; Protease-Activated Receptor 1	Human	HEK293
	The thrombin receptor/PAR1 protein is a high-affinity receptor for activated thrombin that is coupled to G proteins to stimulate phosphoinositide hydrolysis. This signaling mechanism suggests its involvement in platelet activation, which is critical for hemostasis and thrombosis. Thrombin Receptor/PAR1 Protein, Human (HEK293, His) is the recombinant human-derived Thrombin Receptor/PAR1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Thrombin Receptor/PAR1 Protein, Human (HEK293, His) is 81 a.a., with molecular weight of ~10.2 kDa.

HY-P702275

	F2RL2 Protein, Human (Cell-Free, His) Proteinase-activated receptor 3; Coagulation factor II receptor-like 2; Thrombin receptor-like 2	Human	E. coli Cell-free
	F2RL2 Protein, a receptor for activated thrombin, activates phosphoinositide hydrolysis through G proteins, participating in intracellular signaling. Its interaction with INSC/inscuteable and potential association with GPSM2 suggest involvement in cellular processes dependent on these interactions. F2RL2 Protein, Human (Cell-Free, His) is the recombinant human-derived F2RL2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of F2RL2 Protein, Human (Cell-Free, His) is 336 a.a., with molecular weight of 40.0 kDa.

HY-P72944

	Coagulation Factor II/F2 Protein, Mouse (HEK293, His) ProThrombin; Coagulation factor II	Mouse	HEK293
	Coagulation Factor II/F2, also known as thrombin, functions as a pivotal serine protease. Its enzymatic action involves cleaving bonds after Arg and Lys residues, facilitating the conversion of fibrinogen to fibrin. Thrombin additionally activates key factors like V, VII, VIII, XIII, and, in conjunction with thrombomodulin, protein C. Beyond blood homeostasis, thrombin plays a role in inflammation and the complex dynamics of wound healing. Coagulation Factor II/F2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Coagulation Factor II/F2 protein, expressed by HEK293 , with C-His labeled tag. The total length of Coagulation Factor II/F2 Protein, Mouse (HEK293, His) is 594 a.a., with molecular weight of ~85 kDa.

HY-P74241

	Coagulation Factor II/F2 Protein, Rat (HEK293, His) ProThrombin; Coagulation factor II	Rat	HEK293
	The factor II/F2 protein (also known as thrombin) plays a key role in blood homeostasis, inflammation, and wound healing. As a multifunctional enzyme, it catalyzes the conversion of fibrinogen into fibrin to form the coagulation network. Coagulation Factor II/F2 Protein, Rat (HEK293, His) is the recombinant rat-derived Coagulation Factor II/F2 protein, expressed by HEK293 , with C-His labeled tag. The total length of Coagulation Factor II/F2 Protein, Rat (HEK293, His) is 593 a.a., with molecular weight of ~69.5 kDa.

HY-P70970

	Serpin B6 Protein, Human (Trx-His) Serpin B6; Cytoplasmic Antiproteinase; CAP; Peptidase Inhibitor 6; PI-6; Placental Thrombin Inhibitor; SERPINB6; PI6; PTI	Human	E. coli
	Serpin B6 protein acts as a potential modulator of serine proteases in the brain or blood. It inhibits cathepsin G, kallikrein 8, and thrombin, suggesting a role in protease regulation. Serpin B6 Protein, Human (Trx-His) is the recombinant human-derived Serpin B6 protein, expressed by E. coli , with N-Trx, N-6*His labeled tag. The total length of Serpin B6 Protein, Human (Trx-His) is 376 a.a., with molecular weight of 58-60 kDa.

HY-P76640

	Serpin B6 Protein, Human (sf9, His) Serpin B6; Cytoplasmic Antiproteinase; CAP; Peptidase Inhibitor 6; PI-6; Placental Thrombin Inhibitor; SERPINB6; PI6; PTI	Human	Sf9 insect cells
	Serpin B6 protein acts as a potential modulator of serine proteases in the brain or blood. It inhibits cathepsin G, kallikrein 8, and thrombin, suggesting a role in protease regulation. Serpin B6 Protein, Human (sf9, His) is the recombinant human-derived Serpin B6 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of Serpin B6 Protein, Human (sf9, His) is 375 a.a., with molecular weight of ~43 kDa.

Cat. No.	Product Name	Chemical Structure

HY-10163S1

Dabigatran-d3
Dabigatran-d₃ is the deuterium labeled Dabigatran. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[1][2].

HY-10163S

Dabigatran-d4
Dabigatran-d₄ is deuterium labeled Dabigatran. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[1][2].

HY-10163S2

Dabigatran-13C6
Dabigatran- ¹³C₆ is the ¹³C labeled Dabigatran[1]. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[2][3].

HY-B0375S

Argatroban-d3

Argatroban-d₃ is the deuterium labeled Argatroban. Argatroban (MD-805) is a direct, selective thrombin inhibitor.

HY-10163S3

Dabigatran-13C,d3
Dabigatran- ¹³C,d₃ is the ¹³C- and deuterium labeled Dabigatran. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[1][2].

HY-10163AS

Dabigatran-d4 hydrochloride

Dabigatran-d₄ (hydrochloride) is deuterium labeled Dabigatran, which is a reversible and selective, direct thrombin inhibitor (DTI) with a K_i value of 4.5 nM.

HY-10264S

Edoxaban-d6

Edoxaban-d₆ is deuterium labeled Edoxaban. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with Kis of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and can be used for stroke prevention. Edoxaban is also a weak inhibitor of thrombin and factor IXaβ (FIXa), with Kis of 6.00 μM and 41.7 μM, respectively, exhibits >10000-fold selectivity for FXa. Edoxaban has antithrombotic properties and has potential for thromboembolic diseases treatment .

Cat. No.	Product Name	Application	Reactivity

HY-P81243

F2 Antibody Des-gamma-carboxy (abnormal)proThrombin; Des-Gamma-carboxy-proThrombin; coagulation factor II (Thrombin); Coagulation factor II; DCP; Factor II; Prepro coagulation factor II; ProThrombin; proThrombin B-chain; PT; RPRGL2; serine protease; THPH1; THRB; THRB_HUMAN; Thrombin heavy chain.	WB=1:500-2000; ELISA=1:5000-10000; IHC-P=1:100-500; IHC-F=1:100-500; Flow-Cyt=1ug/test; IF=1:100-500	Human, Mouse, Rat

HY-P81126

PAR1 Antibody SAR; PAR-1; PAR 1; BXR; CF2R; F2R; HTR; TR; Proteinase-activated receptor 1 precursor; Proteinase activated receptor 1; Thrombin receptor; Coagulation factor II receptor; Prader-Willi/Angelman region-1; Coagulation factor II (Thrombin) receptor; PAR1_HUMAN	WB; ELISA; IHC-P; IHC-F; IF	Human, Mouse, Rat,
PAR1 Antibody is an unconjugated, approximately 42 kDa, rabbit-derived, anti-PAR1 polyclonal antibody. PAR1 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, mouse, rat, background without labeling.


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