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Cat. No.: HY-151146

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(1R,3S)-THCCA-Asn

(1R,3S)-THCCA-Asn (4j) is a selective thrombin inhibitor with the IC₅₀ value in the range of 0.07 to 0.14 μM. ((1R,3S)-THCCA-Asn has antithrombotic activity.

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CAS No.: 1349084-71-4
Formule: C₂₄H₂₄N₄O₆
Masse moléculaire:464.47

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

(1R,3S)-THCCA-Asn Chemical Structure

CAS No.: 1349084-71-4

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

(1R,3S)-THCCA-Asn (4j) is a selective thrombin inhibitor with the IC₅₀ value in the range of 0.07 to 0.14 μM. ((1R,3S)-THCCA-Asn has antithrombotic activity^[1].

In Vitro

(1R,3S)-THCCA-Asn (4j) (0.001-500 μM) has anti-platelet aggregation activity with the IC₅₀ value ranged from 0.07 μM to 0.14 μM, and inhibits ADP-induced platelet aggregation by less than 20% as well as AA-induced platelet aggregation by less than 10%^[1].
(1R,3S)-THCCA-Asn (4j) (0.001-1000 μM, 48 h) has less toxic to mammalian cells such as liver cell, colon mucosa cell and human dermal fibroblasts in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

Liver cell (L02), colon mucosa cell (NCM460) and human dermal fibroblasts cell (NHDF)
Concentration:

0.001-1000 μM
Incubation Time:

48 hours
Result:

Showed that the IC₅₀ values for cell viability were all higher than 125 μM.

In Vivo

(1R,3S)-THCCA-Asn (4j) (p.o., 0.001-1 nM/kg) can act against thrombosis of rats in a dose-dependent manner with no toxic side effects^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male SD (Sprague Dawley) rats weighing 250-300 g^[1]
Dosage:

0.001, 0.01, 1 nM/kg
Administration:

p.o.
Result:

Resulted in a reduction in thrombus weight of 19.19 mg at the dose of 1 nM/kg compared to the untreated thrombus weight of about 30 mg.

Chemical Information

CAS No. 1349084-71-4
Masse moléculaire 464.47
Formule C₂₄H₂₄N₄O₆
SMILES

OC1=CC=C([C@H]2N[C@@H](CC3=C2NC4=C3C=CC=C4)C(N[C@@H](CC(N)=O)C=O)=O)C=C1C(OC)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Xiaoyi Zhang, et al. (1R,3S)-THCCA-Asn: To show the discovery of selective inhibitor of thrombin by successfully combining virtual screening and biological assay,European Journal of Medicinal Chemistry,Volume 242,2022,114681.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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