(1R,3S)-THCCA-Asn
(1R,3S)-THCCA-Asn (4j) is a selective thrombin inhibitor with the IC50 value in the range of 0.07 to 0.14 μM. ((1R,3S)-THCCA-Asn has antithrombotic activity.
For research use only. We do not sell to patients.
- CAS No.: 1349084-71-4
- Formula: C24H24N4O6
- Molecular Weight:464.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
(1R,3S)-THCCA-Asn (4j) (0.001-500 μM) has anti-platelet aggregation activity with the IC50 value ranged from 0.07 μM to 0.14 μM, and inhibits ADP-induced platelet aggregation by less than 20% as well as AA-induced platelet aggregation by less than 10%[1].
(1R,3S)-THCCA-Asn (4j) (0.001-1000 μM, 48 h) has less toxic to mammalian cells such as liver cell, colon mucosa cell and human dermal fibroblasts in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Liver cell (L02), colon mucosa cell (NCM460) and human dermal fibroblasts cell (NHDF)
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Concentration:0.001-1000 μM
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Incubation Time:48 hours
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Result:Showed that the IC50 values for cell viability were all higher than 125 μM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male SD (Sprague Dawley) rats weighing 250-300 g[1]
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Dosage:0.001, 0.01, 1 nM/kg
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Administration:p.o.
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Result:Resulted in a reduction in thrombus weight of 19.19 mg at the dose of 1 nM/kg compared to the untreated thrombus weight of about 30 mg.
Chemical Information
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CAS No. 1349084-71-4
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Molecular Weight 464.47
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Formula C24H24N4O6
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SMILES
OC1=CC=C([C@H]2N[C@@H](CC3=C2NC4=C3C=CC=C4)C(N[C@@H](CC(N)=O)C=O)=O)C=C1C(OC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(1R,3S)-THCCA-Asn Related Classifications
HY-151146 Related Classifications
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