2. Metabolic Enzyme/Protease
  3. Thrombin
  4. (1R,3S)-THCCA-Asn

(1R,3S)-THCCA-Asn (4j) is a selective thrombin inhibitor with the IC50 value in the range of 0.07 to 0.14 μM. ((1R,3S)-THCCA-Asn has antithrombotic activity.

For research use only. We do not sell to patients.

(1R,3S)-THCCA-Asn Chemical Structure

(1R,3S)-THCCA-Asn Chemical Structure

CAS No. : 1349084-71-4

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

(1R,3S)-THCCA-Asn Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

(1R,3S)-THCCA-Asn (4j) is a selective thrombin inhibitor with the IC50 value in the range of 0.07 to 0.14 μM. ((1R,3S)-THCCA-Asn has antithrombotic activity[1].

In Vitro

(1R,3S)-THCCA-Asn (4j) (0.001-500 μM) has anti-platelet aggregation activity with the IC50 value ranged from 0.07 μM to 0.14 μM, and inhibits ADP-induced platelet aggregation by less than 20% as well as AA-induced platelet aggregation by less than 10%[1].
(1R,3S)-THCCA-Asn (4j) (0.001-1000 μM, 48 h) has less toxic to mammalian cells such as liver cell, colon mucosa cell and human dermal fibroblasts in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(1R,3S)-THCCA-Asn Related Antibodies

Cell Proliferation Assay[1]

Cell Line: Liver cell (L02), colon mucosa cell (NCM460) and human dermal fibroblasts cell (NHDF)
Concentration: 0.001-1000 μM
Incubation Time: 48 hours
Result: Showed that the IC50 values for cell viability were all higher than 125 μM.
In Vivo

(1R,3S)-THCCA-Asn (4j) (p.o., 0.001-1 nM/kg) can act against thrombosis of rats in a dose-dependent manner with no toxic side effects[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male SD (Sprague Dawley) rats weighing 250-300 g[1]
Dosage: 0.001, 0.01, 1 nM/kg
Administration: p.o.
Result: Resulted in a reduction in thrombus weight of 19.19 mg at the dose of 1 nM/kg compared to the untreated thrombus weight of about 30 mg.
Molecular Weight

464.47

Formula

C24H24N4O6
CAS No.
SMILES

OC1=CC=C([C@H]2N[C@@H](CC3=C2NC4=C3C=CC=C4)C(N[C@@H](CC(N)=O)C=O)=O)C=C1C(OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

(1R,3S)-THCCA-Asn Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(1R,3S)-THCCA-Asn1349084-71-4Thrombinthrombinanti-platelet aggregationanti-thrombotic activityInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
(1R,3S)-THCCA-Asn
Cat. No.:
HY-151146
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.