(1R,3S)-THCCA-Asn
(1R,3S)-THCCA-Asn (4j) is a selective thrombin inhibitor with the IC50 value in the range of 0.07 to 0.14 μM. ((1R,3S)-THCCA-Asn has antithrombotic activity.
For research use only. We do not sell to patients.
- CAS No.: 1349084-71-4
- Formula: C24H24N4O6
- Molecular Weight:464.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
(1R,3S)-THCCA-Asn (4j) (0.001-500 μM) has anti-platelet aggregation activity with the IC50 value ranged from 0.07 μM to 0.14 μM, and inhibits ADP-induced platelet aggregation by less than 20% as well as AA-induced platelet aggregation by less than 10%[1].
(1R,3S)-THCCA-Asn (4j) (0.001-1000 μM, 48 h) has less toxic to mammalian cells such as liver cell, colon mucosa cell and human dermal fibroblasts in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Liver cell (L02), colon mucosa cell (NCM460) and human dermal fibroblasts cell (NHDF)
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Concentration:0.001-1000 μM
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Incubation Time:48 hours
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Result:Showed that the IC50 values for cell viability were all higher than 125 μM.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male SD (Sprague Dawley) rats weighing 250-300 g[1]
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Dosage:0.001, 0.01, 1 nM/kg
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Administration:p.o.
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Result:Resulted in a reduction in thrombus weight of 19.19 mg at the dose of 1 nM/kg compared to the untreated thrombus weight of about 30 mg.
Chemical Information
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CAS No. 1349084-71-4
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Molecular Weight 464.47
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Formula C24H24N4O6
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SMILES
OC1=CC=C([C@H]2N[C@@H](CC3=C2NC4=C3C=CC=C4)C(N[C@@H](CC(N)=O)C=O)=O)C=C1C(OC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(1R,3S)-THCCA-Asn Related Classifications
HY-151146 Related Classifications
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