IL-18 Receptor
IL-18 Receptor is an interleukin receptor of the immunoglobulin superfamily. IL-18 Receptor consists of two distinct domains, IL-18Rα and IL-18Rβ. IL-18Rα alone has a weak affinity for IL-18 binding, while the IL-18Rα/β complex has a high affinity[1]. IL-18 binds to IL-18 receptor complex and activates NF-κB, MAPKs, PI3K/AKT signaling modules leading to the production and release of proinflammatory cytokines[2].
- [1]. Wu C, et al. IL-18 receptor beta-induced changes in the presentation of IL-18 binding sites affect ligand binding and signal transduction. J Immunol. 2003 Jun 1;170(11):5571-7. [Content Brief]
- [2]. Rex DAB, et al. A comprehensive pathway map of IL-18-mediated signalling. J Cell Commun Signal. 2020 Jun;14(2):257-266. [Content Brief]
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IL-18 Receptor Recombinant Proteins (21)
- Species:
- Source:
- 1
- 2
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- 2
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
