LAMP-1/CD107a
LAMP-1 (CD107a) is a heavily glycosylated type I transmembrane protein that coats the lumenal side of lysosomal and late endosomal membranes, protecting them from luminal hydrolases. Upon degranulation, cytotoxic T cell and NK cell lysosomes fuse with the plasma membrane, transiently displaying CD107a at the cell surface; this property is exploited in the widely used CD107a degranulation assay for cytolytic lymphocyte activity. CD107a is thus also a marker of activated platelets and of NK cell function. Elevated surface LAMP-1 on tumor cells has been associated with invasive behavior and metastasis. Functionally, its poly-lactosamine glycans also contribute to cell adhesion and migration in tumor models.
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LAMP-1/CD107a Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 화학식: Human
- 분자량: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
