IL-12 Receptor
The IL-12 receptor is a type I cytokine receptor that binds to IL-12. It is mainly expressed on NK and T cells, consists of beta 1 and beta 2 subunits, and is a member of the gp130 cytokine receptor superfamily. IL-12R, when bound to its ligand IL-12, activates a series of signaling pathways. Among them, IL-12Rβ1 binds to tyrosine kinase 2 (Tyk2), while IL-12Rβ2 binds to Janus Kinase 2 (JAK2). In contrast, Tyk2 and JAK2 phosphorylate tyrosine residues mainly on signal transducer and activator of transcription 4 (STAT4). Eventually, the STAT4 complex localizes to the nucleus and binds to the IFNγ promoter, while the Jun oncogene (c-Jun) is recruited to the IFNγ promoter via STAT4, enhancing IFNγ transcription and Th1 differentiation. The IL-12R-mediated signaling pathway is thus also relevant to IFN-γ-associated autoimmune inflammatory diseases such as collagen-induced arthritis (CIA) and colitis[1][2].
-
IL-12 Receptor Recombinant Proteins (9)
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
