2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Interleukin & Receptors
  5. IL-12 Receptor

IL-12 Receptor

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The IL-12 receptor is a type I cytokine receptor that binds to IL-12. It is mainly expressed on NK and T cells, consists of beta 1 and beta 2 subunits, and is a member of the gp130 cytokine receptor superfamily. IL-12R, when bound to its ligand IL-12, activates a series of signaling pathways. Among them, IL-12Rβ1 binds to tyrosine kinase 2 (Tyk2), while IL-12Rβ2 binds to Janus Kinase 2 (JAK2). In contrast, Tyk2 and JAK2 phosphorylate tyrosine residues mainly on signal transducer and activator of transcription 4 (STAT4). Eventually, the STAT4 complex localizes to the nucleus and binds to the IFNγ promoter, while the Jun oncogene (c-Jun) is recruited to the IFNγ promoter via STAT4, enhancing IFNγ transcription and Th1 differentiation. The IL-12R-mediated signaling pathway is thus also relevant to IFN-γ-associated autoimmune inflammatory diseases such as collagen-induced arthritis (CIA) and colitis[1][2].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P74834
    IL-12R beta 2 Protein, Mouse (HEK293, His)

    Interleukin-12 receptor subunit beta-2; IL-12R-beta-2; IL-12RB2

    		Mouse HEK293
    IL-12R beta 2 protein is an IL-12 cytokine surface receptor that activates the Jak-Stat signaling cascade pathway and is involved in IL-12-mediated immune regulation. IL-12R beta 2 Protein, Mouse (HEK293, His) is expressed by HEK 293 cells with a transmembrane region (W638-I658) and a His tag at the C-terminus.
  • HY-P70647
    IL-12R beta 1 Protein, Human (HEK293, His)

    CD212; IL12RB1; CD212; CD212 antigen; IL-12 receptor beta component; IL-12 receptor subunit beta-1; IL12R; IL-12R subunit beta-1; IL12RB; IL-12RB1; IL-12R-BETA1; IL-12R-beta-1; interleukin-12 receptor beta-1 chain; interleukin-12 receptor subunit beta-1

    		Human HEK293
    IL-12R beta 1 protein is an IL-12 cytokine surface receptor that activates the Jak-Stat signaling cascade pathway and is involved in IL-12-mediated immune regulation. IL-12R beta 1 Protein, Human (HEK293, His) is expressed by HEK 293 cells with a transmembrane region (W546-L570) and a C-terminal 6*His tag.
  • HY-P72596
    IL-12R beta 2 Protein, Mouse (HEK293, Fc)

    Interleukin-12 receptor subunit beta-2; IL-12R-beta-2; IL-12RB2

    		Mouse HEK293
    IL-12R beta 2 protein is an IL-12 cytokine surface receptor that activates the Jak-Stat signaling cascade pathway and is involved in IL-12-mediated immune regulation. IL-12R beta 2 Protein, Mouse (HEK293, Fc) is expressed by HEK 293 cells with a transmembrane region (W638-I658) and a hFc tag at the C-terminus.
Cat. No. Product Name Effect Purity