IL-12R beta 2
IL-12 receptor is a type I cytokine receptor that binds to IL-12. IL-12 receptor is expressed primarily on NK and T cells and consists of beta 1 and beta 2 subunits and is a member of the gp130 cytokine receptor superfamily. IL-12R beta 2 (abbreviated IL-12R2 or IL-12Rβ2) is a subunit of the IL-12 receptor, and IL-12Rβ2 is its human gene name. Co-expression of IL-12Rβ2 protein and IL-12Rβ1 protein can lead to the formation of high-affinity IL-12 binding sites and the reconstitution of IL-12-dependent signaling. Upon IL-12 binding to the IL-12 receptor, the cytoplasmic protein TYK2, which interacts directly with IL-12Rβ1, and JAK2, which interacts with IL-12Rβ2, are tyrosine phosphorylated. Phosphorylated TYK2 and JAK2 are required for subsequent tyrosine phosphorylation and activation of STAT4 that binds to IL-12Rβ2. STAT4 is a transcription factor that subsequently homodimerizes, translocates to the nucleus and binds to its target DNA to activate transcription of IFN-γ and other target genes[1].
Expression of the IL-12Rβ2 chain is thought to be a key factor in controlling T cell development and function. It plays an important role in Th1 cell differentiation and deletion results in failure of Th1 differentiation and dysfunctional production of Th1 effector molecules. Up-regulation of this gene has been found to be associated with many infectious diseases, such as Crohn's disease and leprosy, which are thought to contribute to the inflammatory response and host defense[2].
- [1]. Esther van de Vosse, et al. IL-12Rβ1 deficiency: mutation update and description of the IL12RB1 variation database. Hum Mutat. 2013 Oct;34(10):1329-39. [Content Brief]
- [2]. Ryuta Nishikomori, et al. Activated STAT4 has an essential role in Th1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling. J Immunol. 2002 Oct 15;169(8):4388-98. [Content Brief]
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IL-12R beta 2 Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
