1. Signaling Pathways
  2. GPCR/G Protein
  3. Urotensin Receptor

Urotensin Receptor

UT receptor

Urotensin receptor (UT) is a G-protein coupled receptor which binds the peptide hormoneurotensin. The urotensin-II (UT) receptor is a Gq/11-protein-coupled receptor that mediates complex hemodynamic effects and influences neuromuscular physiology. The UT receptor displays greatest expression levels in the peripheral vasculature, heart and kidney, although they are found elsewhere, notably the central nervous system, at lower levels. The UT receptor produces potent but variable vasoconstrictor effects in some vascular beds, yet mediates vasodilation in others; it has also been implicated in osmoregulation.

Urotensin Receptor Related Products (19):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-10655
    Palosuran
    Antagonist 99.69%
    Palosuran (ACT-058362) is a potent, selective, and orally active antagonist of urotensin II receptor, with an IC50 of 3.6 nM for CHO cell membranes expressing human recombinant receptors. Palosuran can improves pancreatic and renal function in diabetic rats.
    Palosuran
  • HY-10664
    SB-611812
    Antagonist 99.31%
    SB-611812 is a urotensin II receptor (UTR) antagonist with the potential in the research of cardiovascular disease.
    SB-611812
  • HY-P1483B
    Urotensin II, mouse acetate
    Activator 99.76%
    Urotensin II, mouse acetate is an endogenous ligand for the orphan G-protein-coupled receptor GPR14 or SENR. Urotensin II, mouse acetate is a potent vasoconstrictor. Urotensin II, mouse acetate plays a physiological role in the central nervous system.
    Urotensin II, mouse acetate
  • HY-P1165
    Urotensin II-related peptide
    98.49%
    Urotensin II-related peptide is a human urotensin II anague. Urotensin II-related peptide has high affinity for the UT receptor.
    Urotensin II-related peptide
  • HY-10656
    SB-657510
    Antagonist 99.84%
    SB-657510 is a selective urotensin II (UII) receptor (UT) antagonist. The Ki values are 61, 17, 30, 65 and 56 nM for human, monkey, cat, rat and mouse receptors, respectively. SB-657510 exerts anti-inflammatory effects by inhibiting UII-induced upregulation of inflammatory mediators such as adhesion molecules, cytokines, and tissue factor in human vascular endothelial cells.
    SB-657510
  • HY-108446
    GSK 1562590 hydrochloride
    Antagonist
    GSK 1562590 hydrochloride is a high affinity and selective antagonist of urotensin-II receptor (UT), with pKis of 9.14-9.66 for mammalian recombinant (mouse, rat, cat, monkey, human) and native UT.
    GSK 1562590 hydrochloride
  • HY-P1168
    [Orn8]-Urotensin II (human)
    Agonist
    [Orn8]-Urotensin II (human), a peptide analog of urotensin II, is a UT receptor agonist. [Orn8]-Urotensin II (human) increases intracellular calcium levels in HEK293.
    [Orn8]-Urotensin II (human)
  • HY-10658
    AC-7954
    AC-7954 is a selective nonpeptidic urotensin receptor agonist (EC50: 300 nM at the human UII receptor).
    AC-7954
  • HY-P1483A
    Urotensin II, mouse TFA
    Activator 99.58%
    Urotensin II, mouse TFA is an endogenous ligand for the orphan G-protein-coupled receptor GPR14 or SENR. Urotensin II, mouse TFA is a potent vasoconstrictor. Urotensin II, mouse TFA plays a physiological role in the central nervous system.
    Urotensin II, mouse TFA
  • HY-P1164A
    Urotensin II (114-124), human TFA
    Agonist 99.76%
    Urotensin II (114-124), human TFA, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.
    Urotensin II (114-124), human TFA
  • HY-P4452
    PRL 2915
    Inhibitor
    PRL 2915 is a potent human somatostatin subtype 2 receptor (hsst2) antagonist with a Ki of 12 nM.
    PRL 2915
  • HY-P4469
    PRL 3195
    Inhibitor
    PRL 3195 is a somatostatin receptor antagonist with Kis of 6, 17, 66, 1000 and 1000 nM for human somatostatin receptors (sst5, sst2, sst3, sst1 and sst4, respectively).
    PRL 3195
  • HY-P1483
    Urotensin II, mouse
    Activator
    Urotensin II, mouse is an endogenous ligand for the orphan G-protein-coupled receptor GPR14 or SENR. Urotensin II, mouse is a potent vasoconstrictor. Urotensin II, mouse plays a physiological role in the central nervous system.
    Urotensin II, mouse
  • HY-P1164
    Urotensin II (114-124), human
    Agonist
    Urotensin II (114-124), human, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.
    Urotensin II (114-124), human
  • HY-10655A
    Palosuran hydrochloride
    Antagonist 98.67%
    Palosuran hydrochloride (ACT-058362 hydrochloride) is a potent, selective, and orally active antagonist of urotensin II receptor, with an IC50 of 3.6 nM for CHO cell membranes expressing human recombinant receptors. Palosuran hydrochloride can improves pancreatic and renal function in diabetic rats.
    Palosuran hydrochloride
  • HY-P1167A
    [Orn5]-URP TFA
    Antagonist
    [Orn5]-URP TFA is a potent and selective pure antagonist of Urotensin-II receptor (UT), with an pEC50 of 7.24. [Orn5]-URP TFA displays no agonist activity.
    [Orn5]-URP TFA
  • HY-P1166
    UFP-803
    Antagonist
    UFP-803 is a potent urotensin-II receptor (UT) ligand. UFP-803 has lower residual agonist activity, so it may be an important tool for the investigations on the role played by the UT system in physiology and pathology.
    UFP-803
  • HY-P1167
    [Orn5]-URP
    Antagonist
    [Orn5]-URP is a potent and selective pure antagonist of Urotensin-II receptor (UT), with an pEC50 of 7.24. [Orn5]-URP displays no agonist activity.
    [Orn5]-URP
  • HY-P1166A
    UFP-803 TFA
    Antagonist
    UFP-803 TFA is a potent urotensin-II receptor (UT) ligand. UFP-803 TFA has lower residual agonist activity, so it may be an important tool for the investigations on the role played by the UT system in physiology and pathology.
    UFP-803 TFA