GSK 1562590 hydrochloride
Based on 1 Customer Validation
GSK 1562590 hydrochloride is a high affinity and selective antagonist of urotensin-II receptor (UT), with pKis of 9.14-9.66 for mammalian recombinant (mouse, rat, cat, monkey, human) and native UT.
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 1003878-07-6
- Formula: C30H31Cl3N4O4
- Molecular Weight:617.95
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-10664
SB-611812
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HY-P1165
Urotensin II-related peptide
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HY-10664R
SB-611812 (Standard)
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HY-10658
AC-7954
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HY-10657
SB-706375
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HY-10656
SB-657510
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HY-P1164
Urotensin II (114-124), human
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HY-10657R
SB-706375 (Standard)
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HY-10656R
SB-657510 (Standard)
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HY-P1166
UFP-803
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![[Orn5]-URP](https://file.medchemexpress.com/product_pic/hy-p1167.gif)
HY-P1167
[Orn5]-URP
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HY-10655A
Palosuran hydrochloride
Biological Activity
Chemical Information
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CAS No. 1003878-07-6
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Appearance Solid
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Molecular Weight 617.95
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Formula C30H31Cl3N4O4
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Color White to off-white
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SMILES
O=C(N([C@H](C1=CC=C(C2=CC=CC(C(N)=O)=C2)C=C1)CN3CCCC3)C)CN4C(COC5=CC(Cl)=C(Cl)C=C45)=O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 25 mg/mL (40.46 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.05 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6183 mL | 8.0913 mL | 16.1825 mL | 40.4563 mL |
| 5 mM | 0.3237 mL | 1.6183 mL | 3.2365 mL | 8.0913 mL | |
| 10 mM | 0.1618 mL | 0.8091 mL | 1.6183 mL | 4.0456 mL | |
| 15 mM | 0.1079 mL | 0.5394 mL | 1.0788 mL | 2.6971 mL | |
| 20 mM | 0.0809 mL | 0.4046 mL | 0.8091 mL | 2.0228 mL | |
| 25 mM | 0.0647 mL | 0.3237 mL | 0.6473 mL | 1.6183 mL | |
| 30 mM | 0.0539 mL | 0.2697 mL | 0.5394 mL | 1.3485 mL | |
| 40 mM | 0.0405 mL | 0.2023 mL | 0.4046 mL | 1.0114 mL |
GSK 1562590 hydrochloride Related Classifications
HY-108446 Related Classifications
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