SB-657510 (Standard)
SB-657510 (Standard) is the analytical standard of SB-657510 (HY-10656). This product is intended for research and analytical applications. SB-657510 is a selective urotensin II (UII) receptor (UT) antagonist. The Ki values are 61, 17, 30, 65 and 56 nM for human, monkey, cat, rat and mouse receptors, respectively. SB-657510 exerts anti-inflammatory effects by inhibiting UII-induced upregulation of inflammatory mediators such as adhesion molecules, cytokines, and tissue factor in human vascular endothelial cells.
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- CAS No.: 474960-44-6
- Formule: C19H22BrClN2O5S
- Masse moléculaire:505.81
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Pureté et documentation
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Help & FAQs
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HY-10656
SB-657510
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HY-10664
SB-611812
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HY-108446
GSK 1562590 hydrochloride
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HY-10657
SB-706375
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HY-P1165
Urotensin II-related peptide
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HY-10664R
SB-611812 (Standard)
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HY-10658
AC-7954
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HY-P1166
UFP-803
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HY-P1164
Urotensin II (114-124), human
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HY-10657R
SB-706375 (Standard)
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![[Orn5]-URP](https://file.medchemexpress.com/product_pic/hy-p1167.gif)
HY-P1167
[Orn5]-URP
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HY-108055
Urantide
Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 474960-44-6
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Masse moléculaire 505.81
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Formule C19H22BrClN2O5S
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SMILES
ClC(C=C1)=C(O[C@H]2CN(C)CC2)C=C1NS(C3=CC(OC)=C(OC)C=C3Br)(=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Park SL, et al. Inhibitory Effect of an Urotensin II Receptor Antagonist on Proinflammatory Activation Inducedby Urotensin II in Human Vascular Endothelial Cells. Biomol Ther (Seoul). 2013 Jul 30;21(4):277-83. [Content Brief]
[2]. Behm DJ, et al. Palosuran inhibits binding to primate UT receptors in cell membranes but demonstrates differential activity in intact cells and vascular tissues. Br J Pharmacol. 2008 Oct;155(3):374-86. [Content Brief]
[3]. Watson AM, et al. Urotensin II receptor antagonism confers vasoprotective effects in diabetes associated atherosclerosis: studies in humans and in a mouse model of diabetes. Diabetologia. 2013 May;56(5):1155-65. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SB-657510 (Standard) Related Classifications
HY-10656R Related Classifications
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