Fc epsilon RIA
Fc epsilon RIA, encoded by the FCER1A gene, is the alpha subunit of the high-affinity IgE receptor Fc epsilon RI and provides the ligand-binding function of the receptor complex. Its two extracellular immunoglobulin-like domains engage the Fc portion of IgE, while the transmembrane segment associates with beta and gamma chains that carry the ITAM motifs required for signaling. The alpha chain is expressed on mast cells and basophils and, at lower levels, on eosinophils, Langerhans cells, and other antigen-presenting cells, enabling allergen capture and presentation. FCER1A expression levels correlate with allergic disease severity, and the receptor is a key pharmacological target in IgE-mediated allergy, asthma, and chronic urticaria.
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Fc epsilon RIA Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
