2. Recombinant Proteins
  3. Viral Proteins
  4. HPV Proteins
  5. HPV E7 Proteins

HPV E7 Proteins

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Cat. No. Product Name / Synonyms Species Source
  • HY-P72259
    Protein E7, HPV (His)

    E7; Protein E7

    		Virus E. coli
    HPV protein E7 can induce dormant cells to enter the cell cycle and promote the efficient use of cellular DNA replication mechanisms for viral genome replication. Through translational and transactivation activities, E7 disrupts the RB1-E2F1 complex and activates E2F1-regulated S-phase genes. Protein E7, HPV (His) is the recombinant Virus-derived protein E7, HPV, expressed by E. coli , with N-6*His labeled tag. The total length of Protein E7, HPV (His) is 98 a.a., with molecular weight of ~21 kDa.
  • HY-P700389
    Protein E7, HPV (N-His, C-His)

    Protein E7

    		Virus E. coli
    Protein E7, HPV, crucially induces quiescent cells to enter the cell cycle, facilitating efficient utilization of cellular DNA replicating machinery for viral genome replication. With transforming and trans-activating activities, E7 disrupts the RB1-E2F1 complex, activating E2F1-regulated S-phase genes. It interferes with host histone deacetylation by HDAC1 and HDAC2, inhibiting antiviral functions of interferon alpha. E7's interaction with host TMEM173/STING hinders sensing cytosolic DNA, repressing type I interferon production. Forming homodimers and homooligomers, E7 associates with RB1, disrupting its activity, and with EP300 to repress transcriptional activity. Complex formation with CHD4 and HDAC1 alters host histone deacetylation, while the interaction with protein E2 inhibits E7 oncogenic activity. E7's multifaceted actions underscore its pivotal role in HPV-associated cellular processes and intricate modulation of host cell functions. Protein E7, HPV (N-His, C-His) is the recombinant Virus-derived protein E7, HPV, expressed by E. coli, with N-6*His, C-6*His labeled tag. The total length of Protein E7, HPV (N-His, C-His) is 98 a.a., with molecular weight of 16.3 kDa.
Cat. No. Product Name Effect Purity