CD324/E-Cadherin
CD324 corresponds to E-cadherin, the epithelial cadherin whose cytoplasmic tail is coupled to the actin cytoskeleton through beta-catenin, alpha-catenin and p120-catenin. Adhesive strands of the molecule zipper neighboring epithelial cells into coherent sheets, and phosphorylation or proteolytic cleavage of the ectodomain loosens these contacts. The gene CDH1 is a bona fide tumor suppressor: germline mutations predispose to hereditary diffuse gastric cancer and lobular breast carcinoma, while transcriptional repression by Snail, Twist and ZEB factors drives the epithelial-mesenchymal transition of invasive carcinomas. Soluble E-cadherin fragments circulate in cancer patients and are studied as biomarkers. Recombinant CD324 is a standard substrate for epithelial adhesion and EMT assays.
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CD324/E-Cadherin Recombinant Proteins (7)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
