1. Recombinant Proteins
  2. CD Antigens Receptor Proteins
  3. Stem Cell CD Proteins Platelet CD Proteins Erythrocyte CD Proteins Epithelial cell CD Proteins Cell Adhesion Molecules (CAMs)
  4. CD324/E-Cadherin Cadherins
  5. E-Cadherin/Cadherin-1
  6. Cadherin-1/CD324 Protein, Rat (HEK293, His)

Cadherin-1/CD324 Protein, Rat (HEK293, His)

Cat. No.: HY-P74367
Handling Instructions

Cadherin-1/CD324 protein, a calcium-dependent adhesion molecule, mediates cell processes. It interacts homophilically with other cadherin molecules, sorting and organizing cell types. CDH1 regulates adhesion, mobility, and proliferation of epithelial cells. It serves as an integrin ligand, suppressing invasion and promoting non-amyloidogenic degradation. CDH1 inhibits APP C99 and C83 production. Cadherin-1/CD324 Protein, Rat (HEK293, His) is the recombinant rat-derived Cadherin-1/CD324 protein, expressed by HEK293, with C-His labeled tag. The total length of Cadherin-1/CD324 Protein, Rat (HEK293, His) is 713 a.a., with molecular weight of ~79 kDa.

For research use only. We do not sell to patients.

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Description

Cadherin-1/CD324 protein, a calcium-dependent adhesion molecule, mediates cell processes. It interacts homophilically with other cadherin molecules, sorting and organizing cell types. CDH1 regulates adhesion, mobility, and proliferation of epithelial cells. It serves as an integrin ligand, suppressing invasion and promoting non-amyloidogenic degradation. CDH1 inhibits APP C99 and C83 production. Cadherin-1/CD324 Protein, Rat (HEK293, His) is the recombinant rat-derived Cadherin-1/CD324 protein, expressed by HEK293, with C-His labeled tag. The total length of Cadherin-1/CD324 Protein, Rat (HEK293, His) is 713 a.a., with molecular weight of ~79 kDa.

Background

Cadherin-1/CD324 protein, a calcium-dependent cell adhesion molecule, plays a pivotal role in various cellular processes. By preferentially interacting with other cadherin molecules of the same type in a homophilic manner, CDH1 contributes to the sorting and organization of different cell types within tissues. Furthermore, it is involved in regulating cell-cell adhesions, mobility, and proliferation of epithelial cells. CDH1 also serves as a ligand for integrin alpha-E/beta-7 and exhibits a potent suppressor role in invasion. Additionally, it promotes the non-amyloidogenic degradation of Abeta precursors and exerts a strong inhibitory effect on the production of APP C99 and C83.

Species

Rat

Source

HEK293

Tag

C-His

Accession

Q9R0T4 (M1-A713)

Gene ID

83502  [NCBI]

Molecular Construction
N-term
CADH1 (M1-A713)
Accession # Q9R0T4
His
C-term
Synonyms
Cadherin-1; CDH1; CAM 120/80; E-cadherin; CD324
Molecular Weight

Approximately 79 kDa

Purity

Greater than 85% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Cadherin-1/CD324 Protein, Rat (HEK293, His)
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HY-P74367
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