Cdh1 - cadherin 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 83502

Summary

Predicted to enable several functions, including GTPase activating protein binding activity; alpha-catenin binding activity; and ankyrin binding activity. Involved in several processes, including nervous system development; regulation of protein catabolic process at postsynapse, modulating synaptic transmission; and response to toxic substance. Located in cytoplasm and plasma membrane. Is active in glutamatergic synapse and postsynapse. Used to study hepatocellular carcinoma and lung adenocarcinoma. Biomarker of pulmonary fibrosis and urinary bladder Cancer. Human ortholog(s) of this gene implicated in several diseases, including blepharocheilodontic syndrome 1; breast Cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system Cancer (multiple); and reproductive organ Cancer (multiple). Orthologous to human CDH1 (Cadherin 1). [provided by Alliance of Genome Resources, Apr 2022]

Cdh1 Products (1)

mRNA	Protein	Name
NM_031334.1	NP_112624.1	cadherin-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	12960056	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12639940	RGD
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	12700184	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of axon extension	IMP IMP: Inferred from mutant phenotype	23226367	RGD
involved in neuron projection development	IEP IEP: Inferred from expression pattern	12387456	RGD
involved in pituitary gland development	IEP IEP: Inferred from expression pattern	17373711	RGD
involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission	IDA IDA: Inferred from direct assay	21186356	RGD
involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission	IEP IEP: Inferred from expression pattern	21186356	RGD
involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission	IMP IMP: Inferred from mutant phenotype	21186356	RGD
involved in response to Gram-positive bacterium	IEP IEP: Inferred from expression pattern	20501441	RGD
involved in response to heparin	IEP IEP: Inferred from expression pattern	16997938	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	17120308	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	16671876	RGD
involved in synapse assembly	IMP IMP: Inferred from mutant phenotype	12123610	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21186356	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	21186356	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	21186356	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
cadherin-1	E-cadherin epithelial cadherin uvomorulin

Recombinant Cdh1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74367	Cadherin-1/CD324 Protein, Rat (HEK293, His)	Q9R0T4 (Q24-A713)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74368	Cadherin-1/CD324 Protein, Rat (HEK293, Fc)	Q9R0T4 (Q24-A713)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N16719	Picrasidine J	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cdh1	NCBI	NCBI:999